ID B1Y1P2_LEPCP Unreviewed; 728 AA.
AC B1Y1P2;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE RecName: Full=Alpha-galactosidase {ECO:0000256|ARBA:ARBA00012755, ECO:0000256|PIRNR:PIRNR005536};
DE EC=3.2.1.22 {ECO:0000256|ARBA:ARBA00012755, ECO:0000256|PIRNR:PIRNR005536};
GN OrderedLocusNames=Lcho_3246 {ECO:0000313|EMBL:ACB35504.1};
OS Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix
OS discophora (strain SP-6)).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Sphaerotilaceae; Leptothrix.
OX NCBI_TaxID=395495 {ECO:0000313|EMBL:ACB35504.1, ECO:0000313|Proteomes:UP000001693};
RN [1] {ECO:0000313|EMBL:ACB35504.1, ECO:0000313|Proteomes:UP000001693}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51168 / LMG 8142 / SP-6
RC {ECO:0000313|Proteomes:UP000001693};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Lykidis A., Emerson D., Richardson P.;
RT "Complete sequence of Leptothrix cholodnii SP-6.";
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of terminal, non-reducing alpha-D-galactose
CC residues in alpha-D-galactosides, including galactose
CC oligosaccharides, galactomannans and galactolipids.; EC=3.2.1.22;
CC Evidence={ECO:0000256|ARBA:ARBA00001255,
CC ECO:0000256|PIRNR:PIRNR005536};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase.
CC {ECO:0000256|PIRNR:PIRNR005536}.
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DR EMBL; CP001013; ACB35504.1; -; Genomic_DNA.
DR RefSeq; WP_012348251.1; NC_010524.1.
DR AlphaFoldDB; B1Y1P2; -.
DR STRING; 395495.Lcho_3246; -.
DR CAZy; GH36; Glycoside Hydrolase Family 36.
DR KEGG; lch:Lcho_3246; -.
DR eggNOG; COG3345; Bacteria.
DR HOGENOM; CLU_009640_3_1_4; -.
DR OMA; WEGIYFD; -.
DR OrthoDB; 9758822at2; -.
DR Proteomes; UP000001693; Chromosome.
DR GO; GO:0004557; F:alpha-galactosidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016052; P:carbohydrate catabolic process; IEA:InterPro.
DR CDD; cd14791; GH36; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 2.70.98.60; alpha-galactosidase from lactobacil brevis; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR038417; Alpga-gal_N_sf.
DR InterPro; IPR002252; Glyco_hydro_36.
DR InterPro; IPR031704; Glyco_hydro_36_N.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR43053:SF3; ALPHA-GALACTOSIDASE-RELATED; 1.
DR PANTHER; PTHR43053; GLYCOSIDASE FAMILY 31; 1.
DR Pfam; PF16875; Glyco_hydro_36N; 1.
DR Pfam; PF02065; Melibiase; 1.
DR PIRSF; PIRSF005536; Agal; 1.
DR PRINTS; PR00743; GLHYDRLASE36.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|PIRNR:PIRNR005536};
KW Hydrolase {ECO:0000256|PIRNR:PIRNR005536, ECO:0000313|EMBL:ACB35504.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001693}.
FT DOMAIN 37..257
FT /note="Glycosyl hydrolase family 36 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16875"
FT ACT_SITE 461
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR005536-1"
FT ACT_SITE 526
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005536-1"
SQ SEQUENCE 728 AA; 79743 MW; 0E6B09603C44F08A CRC64;
MNTRTHSASL PDSPAQFIAL HGRASSIVIE AHADEAPIWR YWGPRLPDAA TPGAALRDSR
PLPSFMLDFD QPLTVAPTFG VGWFGQSALL AHRDGLDFAQ AYTRCEIEWL APGSAVCLHL
HDDVARLRLD LTLKLDAASD VLTLQSTLHN LGDSAIDVQW LASGTLPLPG HSQQVRSYAG
QHVHEFLLQT DPLTRSLWRK ESRRGRTSHD CFPGAVVTTP GATDDAGLVF GAHLAWSGNH
QQTIEWLHDG QYQWQMGEWL APGEGRLAPG QALHTPEIVA SCSTAGLNGL AANFHAELRS
RLNWPGGAMR ARPVHLNTWE GFYFDVHPGP VKELATAAAA VGIERFVLDD GWFHGRHHDR
AALGDWWPDE SKFPAGLGEL IGHVNGLGMS FGLWVEPEMV NPDSELFRAH PDWALQVAGR
PLLTARNQLV LDISRPEAAD YLFDKISALL AAHPIDYLKW DHNRDLAPAG LANGAPGYRA
QVHAVYALMA RLRAAHPQVE IESCSGGGGR IDFAVLRHTH RVWTSDCIDA LSRVAIQRGF
LQFFPPEIMG SHVGTAPSHT TGRTQNMAFR AAVALPGHLG VELDVRHLNE AETTELRAWI
ALYKQLRDRL HTGRVWLGEV ADGIAWQAHG NAAAGDVLLL VYRTAPSSHR YTPVLRLTML
DAGARYRVHE VLPDGTVRAT GHHNTAPFFD AINTPEGLTL DGAWLAHAGL PLPRAQAETA
FIVRLQKV
//