ID   B1Y2P8_LEPCP            Unreviewed;      1245 AA.
AC   B1Y2P8;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=5-oxoprolinase (ATP-hydrolyzing) {ECO:0000313|EMBL:ACB34390.1};
DE            EC=3.5.2.9 {ECO:0000313|EMBL:ACB34390.1};
GN   OrderedLocusNames=Lcho_2123 {ECO:0000313|EMBL:ACB34390.1};
OS   Leptothrix cholodnii (strain ATCC 51168 / LMG 8142 / SP-6) (Leptothrix
OS   discophora (strain SP-6)).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Sphaerotilaceae; Leptothrix.
OX   NCBI_TaxID=395495 {ECO:0000313|EMBL:ACB34390.1, ECO:0000313|Proteomes:UP000001693};
RN   [1] {ECO:0000313|EMBL:ACB34390.1, ECO:0000313|Proteomes:UP000001693}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51168 / LMG 8142 / SP-6
RC   {ECO:0000313|Proteomes:UP000001693};
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA   Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Lykidis A., Emerson D., Richardson P.;
RT   "Complete sequence of Leptothrix cholodnii SP-6.";
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
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DR   EMBL; CP001013; ACB34390.1; -; Genomic_DNA.
DR   RefSeq; WP_012347150.1; NC_010524.1.
DR   AlphaFoldDB; B1Y2P8; -.
DR   STRING; 395495.Lcho_2123; -.
DR   KEGG; lch:Lcho_2123; -.
DR   eggNOG; COG0145; Bacteria.
DR   eggNOG; COG0146; Bacteria.
DR   HOGENOM; CLU_002157_0_0_4; -.
DR   OrthoDB; 9768323at2; -.
DR   Proteomes; UP000001693; Chromosome.
DR   GO; GO:0017168; F:5-oxoprolinase (ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR   InterPro; IPR049517; ACX-like_C.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase_fam.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   PANTHER; PTHR11365:SF23; HYPOTHETICAL 5-OXOPROLINASE (EUROFUNG)-RELATED; 1.
DR   Pfam; PF19278; Hydant_A_C; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 1.
DR   Pfam; PF02538; Hydantoinase_B; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:ACB34390.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001693}.
FT   DOMAIN          8..186
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          206..500
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          525..703
FT                   /note="Acetophenone carboxylase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19278"
FT   DOMAIN          718..1238
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
SQ   SEQUENCE   1245 AA;  130597 MW;  8CF4A3BEDCB029C1 CRC64;
     MSDAAWQFWI DRGGTFTDVI GCDADDRLHP LKLLSENPGQ YADAAVEGIR RLLGLRPGEP
     ITPQRVACVK MGTTVATNAL LERKGERTLL VTTRGFRDAL RIAWQARPQL FERRIVLPEL
     LYETVIEADE RIGADGTVVT PFDPDALRAQ LQQAFDTGLR ACAIVFMHGW RHTAHEAAAA
     ELARAIGYTQ VSVSHEVSPL MKLVSRGDTT VVDAYLSPIL RRYVDRVAAQ MPGVRLFFMQ
     SSGGLAQAQA FHGKDAVLSG PAGGIVGMVR TALAAGHRQV IGFDMGGTST DVSHFSAAAG
     EGGDAQFERV FETQVAGVRI RAPMMAIHTV AAGGGSVIHF DGARLRVGPH SAGADPGPAC
     YRRGGPLAVT DANLLLGKIA PAFFPRVFGP DADQPLDPAA ARAGFADLAE QVTRASGRPT
     TPEQVAAGAL QIAVASMANA IKRISVAKGH DVTRYTLQCF GGAGGQHACA VADALGMQRV
     CIHPLAGVLS AYGMGLADQL ALREASLEMA FDAAGLAAAR ARLLDLQSAA AAELTTQGVA
     SDGLRMRWQL RLRYQGTDTA LALTWAQVAA LDAASDAASL DALRLDFEAA YRQRFAFLMP
     GRPLLIEAVA VEVAAPGQGL PAAAPEAVAV PHVPTAHSAV SVYTEASDGT PGWCAAQLYL
     GADLRPGATL TGPAIVADRN ATTVVEPGWQ ATLDAAGVLE LQRVLPRASR QALGTAVDPV
     LLEVFNQLFM AIAEQMGQRL QNTAHSVNIK ERLDFSCALF DADGALIANA PHMPVHLGSM
     GEAIRSVIER NPALRPGDVY ALNDPYHGGT HLPDVTVVTP VWLDGDDRPA FYVASRGHHA
     DIGGISPGSM PPFSTTIADE GVLIDNFLLA RSGVLREAEL LALLAGGPWP ARNPQQNLAD
     LRAQIAANQK GVQELQSMVA QYGRATVAAY MRHVQDNAEA CVRRAIGALQ QGGLGTGRFE
     LPLDNGAVVR VQVSVDAAER SAVIDFSGTS AQLPNNFNAP KAVTLAAVLY VFRTLVDDQI
     PLNAGCLKPL QVIVPAGCML NPNPPAAVVA GNVETSTCVT NALYGALGVM AAAQCTMNNF
     TFGNARHQYY ETISGGSGAG GLFDAQGALV GGFDGTSVVQ THMTNSRLTD PEVLEWRFPV
     RLESYAIRTG SGGAGSWRGG DGGTRRIRFL EPMSAGILSN GRTQGAFGLA GGSAGQVGAN
     RIERADGRVE PLGHIGAVEV GVGDVFVIET PGGGGFGRGL NDPAT
//