ID B1YKK6_EXIS2 Unreviewed; 532 AA.
AC B1YKK6;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE SubName: Full=Diguanylate cyclase {ECO:0000313|EMBL:ACB60189.1};
GN OrderedLocusNames=Exig_0708 {ECO:0000313|EMBL:ACB60189.1};
OS Exiguobacterium sibiricum (strain DSM 17290 / CIP 109462 / JCM 13490 /
OS 255-15).
OC Bacteria; Bacillota; Bacilli; Bacillales;
OC Bacillales Family XII. Incertae Sedis; Exiguobacterium.
OX NCBI_TaxID=262543 {ECO:0000313|EMBL:ACB60189.1, ECO:0000313|Proteomes:UP000001681};
RN [1] {ECO:0000313|EMBL:ACB60189.1, ECO:0000313|Proteomes:UP000001681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17290 / CIP 109462 / JCM 13490 / 255-15
RC {ECO:0000313|Proteomes:UP000001681};
RX PubMed=16489412; DOI=10.1007/s00792-005-0497-5;
RA Rodrigues D.F., Goris J., Vishnivetskaya T., Gilichinsky D.,
RA Thomashow M.F., Tiedje J.M.;
RT "Characterization of Exiguobacterium isolates from the Siberian permafrost.
RT Description of Exiguobacterium sibiricum sp. nov.";
RL Extremophiles 10:285-294(2006).
RN [2] {ECO:0000313|EMBL:ACB60189.1, ECO:0000313|Proteomes:UP000001681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17290 / CIP 109462 / JCM 13490 / 255-15
RC {ECO:0000313|Proteomes:UP000001681};
RX PubMed=19019206; DOI=10.1186/1471-2164-9-547;
RA Rodrigues D.F., Ivanova N., He Z., Huebner M., Zhou J., Tiedje J.M.;
RT "Architecture of thermal adaptation in an Exiguobacterium sibiricum strain
RT isolated from 3 million year old permafrost: a genome and transcriptome
RT approach.";
RL BMC Genomics 9:547-547(2008).
RN [3] {ECO:0000313|Proteomes:UP000001681}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17290 / CIP 109462 / JCM 13490 / 255-15
RC {ECO:0000313|Proteomes:UP000001681};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kiss H., Chertkov O., Monk C.,
RA Brettin T., Detter J.C., Han C., Kuske C.R., Schmutz J., Larimer F.,
RA Land M., Hauser L., Kyrpides N., Mikhailova N., Vishnivetskaya T.,
RA Rodrigues D.F., Gilichinsky D., Tiedje J., Richardson P.;
RT "Complete sequence of chromosome of Exiguobacterium sibiricum 255-15.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP001022; ACB60189.1; -; Genomic_DNA.
DR RefSeq; WP_012369613.1; NC_010556.1.
DR AlphaFoldDB; B1YKK6; -.
DR STRING; 262543.Exig_0708; -.
DR KEGG; esi:Exig_0708; -.
DR eggNOG; COG2199; Bacteria.
DR HOGENOM; CLU_000445_134_0_9; -.
DR OrthoDB; 9759607at2; -.
DR Proteomes; UP000001681; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd12914; PDC1_DGC_like; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR033479; dCache_1.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR PANTHER; PTHR46663; DIGUANYLATE CYCLASE DGCT-RELATED; 1.
DR PANTHER; PTHR46663:SF2; GGDEF DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF02743; dCache_1; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF00672; HAMP; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001681};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 314..366
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 401..532
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
SQ SEQUENCE 532 AA; 59656 MW; 69624482F917B54A CRC64;
MKKFSIRFDA LLALLIAGLF FVMTLSLTFL ISNRATDRLK DEVGTTLSAT AYQLSDKLDH
YMWSRTAEVN VLRTLPTIRD GKNPAETRNT LEQLQQQIPD FSWIGVMNPD GQVIASTGKI
LEGQSIKARP VFQEAQKKPF IGDVHDAVLL AKLLPNPSGE PLQFVDISTP LFTNGKMTGV
LATHLSFEWA KEIEQSFQSS TAQIKDVEFL IVSKQNRTVL LGPKQWRGKN LPSDWLAGNQ
KGYRISNWEN DQEYLIGVAE SKGYKNYNGL GWTVLVRQPS QIAFSDASTL RNYILIAGLI
ASLLTAIIGW FVARLLTRPL KKITLAAEAM QHDRSKSIPA HTGIREIEVL SVALRELTTK
LTHTEQERTT YESLALHDAL TGLPNRNGLS EYLDGLSRKT HDQIYLYLDL DGFKAVNDQY
GHAMGDLLLI EVADRLQKSL RYEGLVARLG GDEFLIILNE PITTEEIDRY GRDIIHTLSY
PYLLNQQTIL IGASIGVAIR SAEESIEQVI HRADIALYDS KHQGKGCLTF HY
//
