ID   B1ZNX4_OPITP            Unreviewed;       920 AA.
AC   B1ZNX4;
DT   20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT   20-MAY-2008, sequence version 1.
DT   27-MAR-2024, entry version 69.
DE   RecName: Full=oxoglutarate dehydrogenase (succinyl-transferring) {ECO:0000256|ARBA:ARBA00012280};
DE            EC=1.2.4.2 {ECO:0000256|ARBA:ARBA00012280};
GN   OrderedLocusNames=Oter_4190 {ECO:0000313|EMBL:ACB77463.1};
OS   Opitutus terrae (strain DSM 11246 / JCM 15787 / PB90-1).
OC   Bacteria; Verrucomicrobiota; Opitutae; Opitutales; Opitutaceae; Opitutus.
OX   NCBI_TaxID=452637 {ECO:0000313|EMBL:ACB77463.1, ECO:0000313|Proteomes:UP000007013};
RN   [1] {ECO:0000313|EMBL:ACB77463.1, ECO:0000313|Proteomes:UP000007013}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 11246 / JCM 15787 / PB90-1
RC   {ECO:0000313|Proteomes:UP000007013};
RX   PubMed=21398538; DOI=10.1128/JB.00228-11;
RA   van Passel M.W., Kant R., Palva A., Copeland A., Lucas S., Lapidus A.,
RA   Glavina del Rio T., Pitluck S., Goltsman E., Clum A., Sun H., Schmutz J.,
RA   Larimer F.W., Land M.L., Hauser L., Kyrpides N., Mikhailova N.,
RA   Richardson P.P., Janssen P.H., de Vos W.M., Smidt H.;
RT   "Genome sequence of the verrucomicrobium Opitutus terrae PB90-1, an
RT   abundant inhabitant of rice paddy soil ecosystems.";
RL   J. Bacteriol. 193:2367-2368(2011).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
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DR   EMBL; CP001032; ACB77463.1; -; Genomic_DNA.
DR   RefSeq; WP_012376991.1; NC_010571.1.
DR   AlphaFoldDB; B1ZNX4; -.
DR   STRING; 452637.Oter_4190; -.
DR   KEGG; ote:Oter_4190; -.
DR   eggNOG; COG0567; Bacteria.
DR   HOGENOM; CLU_004709_1_0_0; -.
DR   OrthoDB; 9759785at2; -.
DR   Proteomes; UP000007013; Chromosome.
DR   GO; GO:0004591; F:oxoglutarate dehydrogenase (succinyl-transferring) activity; IEA:UniProtKB-EC.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
DR   CDD; cd02016; TPP_E1_OGDC_like; 1.
DR   Gene3D; 3.40.50.12470; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.50.11610; Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain; 1.
DR   Gene3D; 1.10.287.1150; TPP helical domain; 1.
DR   InterPro; IPR032106; 2-oxogl_dehyd_N.
DR   InterPro; IPR011603; 2oxoglutarate_DH_E1.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR031717; KGD_C.
DR   InterPro; IPR042179; KGD_C_sf.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   NCBIfam; TIGR00239; 2oxo_dh_E1; 1.
DR   PANTHER; PTHR23152:SF4; 2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1; 1.
DR   PANTHER; PTHR23152; 2-OXOGLUTARATE DEHYDROGENASE; 1.
DR   Pfam; PF16078; 2-oxogl_dehyd_N; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF16870; OxoGdeHyase_C; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   PIRSF; PIRSF000157; Oxoglu_dh_E1; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:ACB77463.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007013};
KW   Thiamine pyrophosphate {ECO:0000256|ARBA:ARBA00023052}.
FT   DOMAIN          584..777
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   920 AA;  103145 MW;  C36FE4256D557F09 CRC64;
     MKPLNVSANA NTAVIEAAYE AWLKQPDSVD PTWRAFFQGF TLGTSGGSLG TEGANLRIID
     SYKQAQVGRF INAHRAHGHL QAHLDPLGEP PPADPKLTLS YFGLDENDLG ESFTLTNFKG
     GGQMKLRDIV DALRQTYCGH IGVEYMHVQE HAAREWLQVR MEQTNNQPRF SRAEKIRILR
     RLHKAELFEK FLHTKYVGQK RFSGEGAETF IAAIDAMLEK CPELGVEEIV MGMAHRGRLN
     VLTSIMRKPF EVLFEQFSEN YLPESVAGDG DVKYHLGYEA ILDTSSGQKV EIRLAANPSH
     LEIVDPVVEG KARARQRVRH ATSERQRVLP FLIHGDAAFA GQGIVAETLN FSQLPGYTTG
     GTVHLVINNQ IGFTTLPHEA RSTRYCTDVA KMVEAPIFHV NGDDAEAVCL VAQLALEFRV
     RFQRDVVIDM VCYRKHGHNE ADEPAFTQPV LYRQIAAHPL VSSILTEKLV REGTITPDEA
     EAIKAEYTAA LEANFERAKA REKEKEGARS VQQSQAIERE KFKGSTAFFQ PAYRHSTIDT
     GAEPALINRV VAGLTTIPGS FKLNPKIRRF LDNRIRAHRE GGPIDWGFGE ALAFGTLLLD
     GTPIRLSGQD CERGTFSHRH AVLYDVDTRE QYVPLKNLDP QQPAFCVYNS LLSEAGVLGF
     DYGYSMDYPQ MLCIWEAQFG DFVNGAQVVI DQFIASSESK WQRASGIVLL LPHGYEGQGP
     EHSSARLERF LGLCAEDNIQ VTNITTPANF FHLLRRQMKR DFRKPLVVMS PKSLLRHPAC
     VSRLDEFTSG RFQEVLDDPK PPAKVERVIY CSGKVYYDLC DFRDRHHLND VAIVRIEQLY
     PLHRDRLAAV ADRYNGARIV WCQEEPQNMG AWTFIAPRLA EIYGFPPKYA GRDAAASPAV
     GALALHKFEL NALLQDAFNI
//