ID B2A4Y6_NATTJ Unreviewed; 890 AA.
AC B2A4Y6;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=CBS domain containing protein {ECO:0000313|EMBL:ACB85228.1};
GN OrderedLocusNames=Nther_1654 {ECO:0000313|EMBL:ACB85228.1};
OS Natranaerobius thermophilus (strain ATCC BAA-1301 / DSM 18059 /
OS JW/NM-WN-LF).
OC Bacteria; Bacillota; Clostridia; Natranaerobiales; Natranaerobiaceae;
OC Natranaerobius.
OX NCBI_TaxID=457570 {ECO:0000313|EMBL:ACB85228.1, ECO:0000313|Proteomes:UP000001683};
RN [1] {ECO:0000313|EMBL:ACB85228.1, ECO:0000313|Proteomes:UP000001683}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF
RC {ECO:0000313|Proteomes:UP000001683};
RG US DOE Joint Genome Institute;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C.,
RA Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA Kyrpides N., Lykidis A., Mesbah N.M., Wiegel J.;
RT "Complete sequence of chromosome of Natranaerobius thermophilus JW/NM-WN-
RT LF.";
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ACB85228.1, ECO:0000313|Proteomes:UP000001683}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-1301 / DSM 18059 / JW/NM-WN-LF
RC {ECO:0000313|Proteomes:UP000001683};
RX PubMed=21642468; DOI=10.1128/JB.05157-11;
RA Zhao B., Mesbah N.M., Dalin E., Goodwin L., Nolan M., Pitluck S.,
RA Chertkov O., Brettin T.S., Han J., Larimer F.W., Land M.L., Hauser L.,
RA Kyrpides N., Wiegel J.;
RT "Complete genome sequence of the anaerobic, halophilic alkalithermophile
RT Natranaerobius thermophilus JW/NM-WN-LF.";
RL J. Bacteriol. 193:4023-4024(2011).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the tRNA nucleotidyltransferase/poly(A)
CC polymerase family. {ECO:0000256|ARBA:ARBA00007265,
CC ECO:0000256|RuleBase:RU003953}.
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DR EMBL; CP001034; ACB85228.1; -; Genomic_DNA.
DR RefSeq; WP_012448096.1; NC_010718.1.
DR AlphaFoldDB; B2A4Y6; -.
DR STRING; 457570.Nther_1654; -.
DR KEGG; nth:Nther_1654; -.
DR eggNOG; COG0517; Bacteria.
DR eggNOG; COG0617; Bacteria.
DR eggNOG; COG0618; Bacteria.
DR HOGENOM; CLU_015961_5_0_9; -.
DR InParanoid; B2A4Y6; -.
DR OrthoDB; 9805698at2; -.
DR Proteomes; UP000001683; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0031123; P:RNA 3'-end processing; IEA:UniProt.
DR CDD; cd04595; CBS_pair_DHH_polyA_Pol_assoc; 1.
DR CDD; cd05398; NT_ClassII-CCAase; 1.
DR Gene3D; 3.10.310.30; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3090.10; cca-adding enzyme, domain 2; 1.
DR Gene3D; 3.90.1640.10; inorganic pyrophosphatase (n-terminal core); 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR001667; DDH_dom.
DR InterPro; IPR038763; DHH_sf.
DR InterPro; IPR003156; DHHA1_dom.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR002646; PolA_pol_head_dom.
DR InterPro; IPR032828; PolyA_RNA-bd.
DR PANTHER; PTHR47788:SF1; A-ADDING TRNA NUCLEOTIDYLTRANSFERASE; 1.
DR PANTHER; PTHR47788; POLYA POLYMERASE; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF01368; DHH; 1.
DR Pfam; PF02272; DHHA1; 1.
DR Pfam; PF01743; PolyA_pol; 1.
DR Pfam; PF12627; PolyA_pol_RNAbd; 1.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF64182; DHH phosphoesterases; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81891; Poly A polymerase C-terminal region-like; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000001683};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU003953};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003953};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555}.
FT DOMAIN 313..380
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 384..440
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 890 AA; 101202 MW; CB6231A7C019CAB9 CRC64;
MKVVTSHQNL DFDGLAAMLA YNKLNPDTKM VLPPKLNQNV RAFYSLYKDT FSFVERINFD
LHKVNTLTMV DTSDEKRIGK LSSILPQVEQ LIIYDHHEYK NLSQNPTIEI NHEVGATSTI
LVEELMNKEI ELSPLEATVI AMGIYEDTGN LTFSHVTARD VRAVAQLLEW GADVDIIRDY
VTIILTQAQR GLLDELISNT KYLNINDYEI GLSITEREEY FSGAAALVHK LMEIEDVDLF
FIIVKMDKKV FVIGRSRREE INVSRILSPF SGKGHDQAAS ATIKHGDLQH IETELIESLK
LHLPVLLTAK AIMSAPVKTI SSSTTIQEAD HLLHKYGHSG LPVVQDKQND IDDEAGKIVG
VISRRDIEKA KHHGFGHSPV KGYMSQKVIS ISPDTSIKEI QHLMVSNDIG RLPVIDSNAN
LIGIVTRTNL LKIQHGQLTE EQERTNLYLK ELDEFSEDIT ELMARRLPSK ILGVLYLIGQ
KADKEGFKVY GVGGFIRDLL LGKDNLDIDL VIEQDAISFA KLVSKHLNGD LKTFSQFQTA
RLTLRSGTRI DFATARIEYY AFPAASPEVE ESTIKQDLYR RDFTINTLAV ELNCNSFGKL
LDFFGGTKDL KKGVIRVLYN LSFVEDPTRI FRAIRFESRF NFNIEEQTLI FIKNSLETGV
LDKLPGERLY EELRNIVDED EAVNTFRRMD ELGIFTKIFP NLNVSQDKLV KLQNIYDILN
WYERENKQKQ EKFVSKEAMV FSCLLQDQPL PIISSILERL KVPQKIRDVI ITTVKETESL
SSKLEYTEKN SELVQNLEEI PLETILFVLA DKENQKIKNK IYYYLEELIG AGVSITGEDL
KTLGIKPGPV YKTALEEVRK ARLDGLVTTP EEELEYVLDF FEQKGEDMHG
//
