ID B2CCA1_ORYLA Unreviewed; 425 AA.
AC B2CCA1; H2MP78;
DT 20-MAY-2008, integrated into UniProtKB/TrEMBL.
DT 20-MAY-2008, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE SubName: Full=Vitamin D (1,25- dihydroxyvitamin D3) receptor {ECO:0000313|Ensembl:ENSORLP00000020536.2};
DE SubName: Full=Vitamin D receptor beta {ECO:0000313|EMBL:ACB38279.1};
GN Name=VDRbeta {ECO:0000313|EMBL:ACB38279.1};
GN Synonyms=vdr {ECO:0000313|Ensembl:ENSORLP00000020536.2};
OS Oryzias latipes (Japanese rice fish) (Japanese killifish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Atherinomorphae; Beloniformes; Adrianichthyidae; Oryziinae;
OC Oryzias.
OX NCBI_TaxID=8090 {ECO:0000313|EMBL:ACB38279.1};
RN [1] {ECO:0000313|Ensembl:ENSORLP00000020536.2, ECO:0000313|Proteomes:UP000001038}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020536.2,
RC ECO:0000313|Proteomes:UP000001038};
RX PubMed=17554307; DOI=10.1038/nature05846;
RA Kasahara M., Naruse K., Sasaki S., Nakatani Y., Qu W., Ahsan B., Yamada T.,
RA Nagayasu Y., Doi K., Kasai Y., Jindo T., Kobayashi D., Shimada A.,
RA Toyoda A., Kuroki Y., Fujiyama A., Sasaki T., Shimizu A., Asakawa S.,
RA Shimizu N., Hashimoto S., Yang J., Lee Y., Matsushima K., Sugano S.,
RA Sakaizumi M., Narita T., Ohishi K., Haga S., Ohta F., Nomoto H., Nogata K.,
RA Morishita T., Endo T., Shin-I T., Takeda H., Morishita S., Kohara Y.;
RT "The medaka draft genome and insights into vertebrate genome evolution.";
RL Nature 447:714-719(2007).
RN [2] {ECO:0000313|EMBL:ACB38279.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18258682; DOI=10.1210/en.2007-1256;
RA Howarth D.L., Law S.H., Barnes B., Hall J.M., Hinton D.E., Moore L.,
RA Maglich J.M., Moore J.T., Kullman S.W.;
RT "Paralogous vitamin D receptors in teleosts: transition of nuclear receptor
RT function.";
RL Endocrinology 149:2411-2422(2008).
RN [3] {ECO:0000313|Ensembl:ENSORLP00000020536.2}
RP IDENTIFICATION.
RC STRAIN=Hd-rR {ECO:0000313|Ensembl:ENSORLP00000020536.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|RuleBase:RU004334}.
CC -!- SIMILARITY: Belongs to the nuclear hormone receptor family.
CC {ECO:0000256|RuleBase:RU004334}.
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DR EMBL; EU403116; ACB38279.1; -; mRNA.
DR RefSeq; NP_001121989.1; NM_001128517.1.
DR RefSeq; XP_011473598.1; XM_011475296.1.
DR STRING; 8090.ENSORLP00000020536; -.
DR Ensembl; ENSORLT00000020537.2; ENSORLP00000020536.2; ENSORLG00000016402.2.
DR GeneID; 100169845; -.
DR KEGG; ola:100169845; -.
DR CTD; 7421; -.
DR eggNOG; KOG3575; Eukaryota.
DR GeneTree; ENSGT00940000155473; -.
DR HOGENOM; CLU_007368_12_0_1; -.
DR OrthoDB; 5359733at2759; -.
DR TreeFam; TF316304; -.
DR Proteomes; UP000001038; Chromosome 5.
DR Bgee; ENSORLG00000016402; Expressed in gastrula and 14 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004879; F:nuclear receptor activity; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0070644; F:vitamin D response element binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0003146; P:heart jogging; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0060119; P:inner ear receptor cell development; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0071599; P:otic vesicle development; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd06955; NR_DBD_VDR; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR042153; DBD_VDR.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR InterPro; IPR000324; VitD_rcpt.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24082:SF504; VITAMIN D3 RECEPTOR B; 1.
DR Pfam; PF00104; Hormone_recep; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00398; STRDHORMONER.
DR PRINTS; PR00047; STROIDFINGER.
DR PRINTS; PR00350; VITAMINDR.
DR SMART; SM00430; HOLI; 1.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU004334};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW Reference proteome {ECO:0000313|Proteomes:UP000001038};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU004334};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU004334};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|RuleBase:RU004334}.
FT DOMAIN 21..96
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 131..421
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 106..133
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 425 AA; 48091 MW; 89F6AC22BE9E5E15 CRC64;
MEATVVSTST LATDEFDRNV PRICGVCGDK ATGFHFNAMT CEGCKGFFRR SMKRKASFTC
PFNGSCTITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV QRKKDLIQRR KDEEAQREAE
REARRPKLTD EQSQTIATLV EAHHKTYDDS YSDFCRFRPP VRDGPVTRSA SRAASLHSLS
DASSDSFSHS PESVDTKMNF NNLLLMYHEQ GSSPDSSEEE GSSLSMLPHL ADLVSYSIQK
VIGFAKMIPG FRELTAEDQI ALLKSSAIEV IMLRSNQSFN LEDMSWSCGA PDFKYQISDV
TKAGHTLDLL EPLVKFQVGL KKLNLQEEEH VLLMAICLLS PDRPGVQDHA RIEALQDRLS
ETLQAYIQLH HPGGRLRYAK MIQKLADLRS LNEEHSKQYR LLSFQPEHSM QLTPLVLEVF
GSEVS
//
