ID B2DD02_MESAU Unreviewed; 758 AA.
AC B2DD02;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Mismatch repair protein {ECO:0000313|EMBL:BAG28292.1, ECO:0000313|RefSeq:NP_001268542.1};
GN Name=MLH1 {ECO:0000313|EMBL:BAG28292.1};
GN Synonyms=Mlh1 {ECO:0000313|RefSeq:NP_001268542.1};
OS Mesocricetus auratus (Golden hamster).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC Cricetidae; Cricetinae; Mesocricetus.
OX NCBI_TaxID=10036 {ECO:0000313|EMBL:BAG28292.1};
RN [1] {ECO:0000313|EMBL:BAG28292.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Liver {ECO:0000313|EMBL:BAG28292.1};
RA Mori C., Sokuza Y., Nishikawa T., Uwataki K., Tsujiuchi T.;
RT "Mesocricetus auratus mismatch repair protein (MLH1) mRNA, complete cds,.";
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001268542.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28071753;
RA McCann K.E., Sinkiewicz D.M., Norvelle A., Huhman K.L.;
RT "De novo assembly, annotation, and characterization of the whole brain
RT transcriptome of male and female Syrian hamsters.";
RL Sci. Rep. 7:40472-40472(2017).
RN [3] {ECO:0000313|RefSeq:NP_001268542.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; AB364509; BAG28292.1; -; mRNA.
DR RefSeq; NP_001268542.1; NM_001281613.1.
DR STRING; 10036.ENSMAUP00000016434; -.
DR GeneID; 101833598; -.
DR KEGG; maua:101833598; -.
DR CTD; 4292; -.
DR eggNOG; KOG1979; Eukaryota.
DR OrthoDB; 5475669at2759; -.
DR Proteomes; UP000189706; Unplaced.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03483; MutL_Trans_MLH1; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 2: Evidence at transcript level;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000189706}.
FT DOMAIN 216..335
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 400..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..480
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 758 AA; 84806 MW; 8CCF17F0BD75C7E5 CRC64;
MAFVAGVIRR LDETVVNRIA AGEVIQRPAN AIKEMIENCL DAKSTNIQVI VKEGGLKLIQ
IQDNGTGIRK EDLDIVCERF TTSKLQTFED LARISTYGFR GEALASISHV AHVTITTKTD
DGKCAYRASY SDGKLQAPPK PCAGNQGTQI TVEDLFYNIM TRRKALKNPS EEYGKILEVV
GRYSIHNSGI SFSVKKQGET VADIRTLPNA TTVDNIRSIF GSAVSRELIE VGCEDKTLAF
KMNGYISNAN YSVKKCIFLL FINHRLVESA ALRKAIETVY AAYLPKNTHP FLYLSLEISP
QNVDVNVHPT KHEVHFLHDE SILERVQQHI EGKLLGSNSS RMYFTQTLLP GLGGPSGECV
KSTAGVTSSS TSGSGDKVYA HQMVRTDSRD QKLDAFMQPV SRRLPSHPQD PVPGNRTEGS
PEKAIQKDQE ISELPAPMEA NGDSRSLERE SVIGASEVVA PQRHCSSSGN PRKRHREDSD
VEMMENESRK EMTAACHPRS SIINLTSVLS LQEEINERGH ETLREMLRNH SFVGCVNPQW
ALAQHQTKLY LLNTTKLSEE LFYQILIYDF ANFGVLRLSE PAPLFDLAML ALDSPESGWT
EEDGPKEGLA EYIVEFLKKK AEMLADYFSL EIDEEGNLIG LPLLIDNYVP PLEGLPLFIL
RLATEVNWDE EKECFESLSK ECAVFYSIRK QYILEESTLS GQQSGMPGST PKPWKWTVEH
IVYKAFRSHL LPPKHFTEDG NVLQLANLPD LYKVFERC
//
