ID B2HF65_MYCMM Unreviewed; 489 AA.
AC B2HF65;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Bifunctional protein: CobI-CobJ fusion protein {ECO:0000313|EMBL:ACC41483.1};
GN Name=cobI {ECO:0000313|EMBL:ACC41483.1};
GN OrderedLocusNames=MMAR_3046 {ECO:0000313|EMBL:ACC41483.1};
OS Mycobacterium marinum (strain ATCC BAA-535 / M).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium ulcerans group.
OX NCBI_TaxID=216594 {ECO:0000313|EMBL:ACC41483.1, ECO:0000313|Proteomes:UP000001190};
RN [1] {ECO:0000313|EMBL:ACC41483.1, ECO:0000313|Proteomes:UP000001190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-535 / M {ECO:0000313|Proteomes:UP000001190};
RX PubMed=18403782; DOI=10.1101/gr.075069.107;
RA Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT "Insights from the complete genome sequence of Mycobacterium marinum on the
RT evolution of Mycobacterium tuberculosis.";
RL Genome Res. 18:729-741(2008).
CC -!- PATHWAY: Cofactor biosynthesis; adenosylcobalamin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004953}.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005879, ECO:0000256|RuleBase:RU003960}.
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DR EMBL; CP000854; ACC41483.1; -; Genomic_DNA.
DR RefSeq; WP_012394736.1; NC_010612.1.
DR AlphaFoldDB; B2HF65; -.
DR STRING; 216594.MMAR_3046; -.
DR KEGG; mmi:MMAR_3046; -.
DR eggNOG; COG1010; Bacteria.
DR eggNOG; COG2243; Bacteria.
DR HOGENOM; CLU_029920_1_0_11; -.
DR OrthoDB; 9804789at2; -.
DR UniPathway; UPA00148; -.
DR Proteomes; UP000001190; Chromosome.
DR GO; GO:0030788; F:precorrin-2 C20-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009236; P:cobalamin biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd11645; Precorrin_2_C20_MT; 1.
DR CDD; cd11646; Precorrin_3B_C17_MT; 1.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006363; Cbl_synth_CobJ/CibH_dom.
DR InterPro; IPR012382; CobI/CbiL.
DR InterPro; IPR006364; CobI/CbiL/CobIJ_dom.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01467; cobI_cbiL; 1.
DR NCBIfam; TIGR01466; cobJ_cbiH; 1.
DR PANTHER; PTHR47036; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR47036:SF1; COBALT-FACTOR III C(17)-METHYLTRANSFERASE-RELATED; 1.
DR Pfam; PF00590; TP_methylase; 2.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 2.
DR PROSITE; PS00839; SUMT_1; 1.
DR PROSITE; PS00840; SUMT_2; 1.
PE 3: Inferred from homology;
KW Cobalamin biosynthesis {ECO:0000256|ARBA:ARBA00022573};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU003960};
KW Reference proteome {ECO:0000313|Proteomes:UP000001190};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003960}.
FT DOMAIN 6..218
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 249..453
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
SQ SEQUENCE 489 AA; 52263 MW; 5E6B61E07C52D7BE CRC64;
MTDRGTLWGV GLGPGDPELV TVKAARVIGE ADVVAYHSAR HGRSIARGIA ERYLRPGQIE
EHLIYPVTTE TTDHPGGYAG ALEDFYEQAT ERIATHLDAG RNVALLAEGD PLFYSSYMHL
HTRLTQRFDA VIVPGVTSVS AASAAIATPL VAGDEVLSVL PGTLPVAELT RRLADVDAAV
VLKLGRSYHN VREALSASGQ LDDTFYVERA STPGQRVLPA ADVDEASVPY FSLAMLPGGR
RSTVVAGTVA VVGLGPGDTD WMTPQSRREL ARATDLIGYG PYLDRISVRD GQRRHPSDNT
DEPARARLAC SLAEQGRAVA VVSSGDPGVF AMATAVLEEA KQWPGVPVRV IPAMTAAQAV
ASRVGAPLGH DYAVISLSDR LKPWEVIAAR LGAAAAADLV LAIYNPASKT RTWQVGAMRE
LLLQHRDPGT PVVIGHNVSG PDEAVRVVRL ADLNPADVDM RCLLIIGSSQ TQWYAVDSTD
RVFTPRRYP
//
