ID B2HIH7_MYCMM Unreviewed; 953 AA.
AC B2HIH7;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Conserved transmembrane transport protein MmpL1_1 {ECO:0000313|EMBL:ACC40171.1};
GN Name=mmpL1_1 {ECO:0000313|EMBL:ACC40171.1};
GN OrderedLocusNames=MMAR_1722 {ECO:0000313|EMBL:ACC40171.1};
OS Mycobacterium marinum (strain ATCC BAA-535 / M).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium ulcerans group.
OX NCBI_TaxID=216594 {ECO:0000313|EMBL:ACC40171.1, ECO:0000313|Proteomes:UP000001190};
RN [1] {ECO:0000313|EMBL:ACC40171.1, ECO:0000313|Proteomes:UP000001190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-535 / M {ECO:0000313|Proteomes:UP000001190};
RX PubMed=18403782; DOI=10.1101/gr.075069.107;
RA Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT "Insights from the complete genome sequence of Mycobacterium marinum on the
RT evolution of Mycobacterium tuberculosis.";
RL Genome Res. 18:729-741(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP000854; ACC40171.1; -; Genomic_DNA.
DR RefSeq; WP_012393536.1; NC_010612.1.
DR AlphaFoldDB; B2HIH7; -.
DR STRING; 216594.MMAR_1722; -.
DR KEGG; mmi:MMAR_1722; -.
DR eggNOG; COG1511; Bacteria.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_3_2_11; -.
DR OrthoDB; 2365435at2; -.
DR Proteomes; UP000001190; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR004707; MmpL_fam.
DR NCBIfam; TIGR00833; actII; 1.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001190};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 19..38
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 192..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..240
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 246..270
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..395
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 763..782
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 789..810
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 822..843
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 864..885
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 897..920
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 51..380
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 601..936
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT REGION 934..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 953 AA; 103056 MW; 021570FE573FDCF6 CRC64;
MTPAHSAGRP FIARTIQKFS LPVILLWIAL TVGANLLAPQ LEEVAKEHSV SLSPSDAPSL
IAMRRIGKDF QQFDSDNTTM IVLESNAKLG DEAHRYYDAL IAKLSQDKTN IQHIDNFWGD
RLTAAGSQSV DGKAAYVQLY LTGGLGSARA NDSVAAVARI LDDVPPPPGI KAYLTGPGAL
GADQDTSGNS SLQRLTAVTI AVITIVLLIA YRSIAAVVVM LLTVGIELLA ARGVIAALAA
NDLIGLSTFA INVLTALTIA ASTDYIIFLV GRYQEARMAG QDRELAYYTM FRGTSHVVLG
SGLTVAGAMY CLSFTRLPYF QTLGSPCSIG LLAVILASLT LAPAVIALTT KFGVFEPKRA
TTTRRWRRIG TIVVRWPGPV LVAAALISLI GLLALPKYQT NYNERHYIPA GAPSNIGYRA
SDRHFPPARM EPEVLMIEAD HDLRNPTDMM LLDRIAKGVF HLPGIARVQG ITRPLGSPLD
HSSIPFQLNM QNAMTIENMG YLKARVADMY TMIDELQHMI DIAARQQELT QQLNDASHDM
LTHNKQMQAN TDQLRDQIAE FDDLWRPIRS YFYWERHCSD IPICWSLRSL FDAIDGVDKL
SEDVGTLTDD LDRIDELQPK LLALLPPMIA TMQTVKSLTQ TTASTFSALI TQMDDMTRNA
TAMGQALDAS KNDDSFYLPP EAFDNPDFQR GLTLFLSPDG TAARFIITHK GDPATAEGIA
HIDPILLAAS EAVKGTPLAA ANIYLAGTAA TYKDISEGST YDLLIAVVAT LCLIFVVMLA
ITRSVVASAV IVGTVALSLG AAFGLSVLLW QHILHMPLHW LVLPMAVIVM LAVGSDYNLL
LVARFQEEIG AGLKTGMIRA MASTGRVVTI AGLVFAFTMG SMLTSDLRVV GQVGTTIMIG
LLFDTLVVRS FMMPAIAALL GRWFWWPRRV PTHAASPPAV TASPGAAATS VLA
//
