ID B2HKX6_MYCMM Unreviewed; 515 AA.
AC B2HKX6;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Fatty acid-CoA ligase FadD13_1 {ECO:0000313|EMBL:ACC40397.1};
GN Name=fadD13_1 {ECO:0000313|EMBL:ACC40397.1};
GN OrderedLocusNames=MMAR_1948 {ECO:0000313|EMBL:ACC40397.1};
OS Mycobacterium marinum (strain ATCC BAA-535 / M).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium ulcerans group.
OX NCBI_TaxID=216594 {ECO:0000313|EMBL:ACC40397.1, ECO:0000313|Proteomes:UP000001190};
RN [1] {ECO:0000313|EMBL:ACC40397.1, ECO:0000313|Proteomes:UP000001190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-535 / M {ECO:0000313|Proteomes:UP000001190};
RX PubMed=18403782; DOI=10.1101/gr.075069.107;
RA Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT "Insights from the complete genome sequence of Mycobacterium marinum on the
RT evolution of Mycobacterium tuberculosis.";
RL Genome Res. 18:729-741(2008).
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DR EMBL; CP000854; ACC40397.1; -; Genomic_DNA.
DR RefSeq; WP_012393738.1; NC_010612.1.
DR AlphaFoldDB; B2HKX6; -.
DR STRING; 216594.MMAR_1948; -.
DR KEGG; mmi:MMAR_1948; -.
DR eggNOG; COG0318; Bacteria.
DR HOGENOM; CLU_000022_59_0_11; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000001190; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR PANTHER; PTHR43767:SF1; NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 2.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:ACC40397.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001190};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 96..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..137
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 147..373
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 423..498
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 515 AA; 54684 MW; DBCA285123E56953 CRC64;
MSSVIEISRD HNPFPRVGVC VDRNGVARYD ELPATLLEML AEQFDSRPDA MAVIEVGGDR
LTYRQLWCRA SRVAGGLRAD GLKPGDRVAV RYPAGINWVL AFWGVLMAGG IAVAVNTRSA
RPEVEFVLND CGARIDLAPQ DALPDGDPYV TEQLGPRDVA ALFYTSGTTG HPKGVPTTHE
AFLTNTENGL RCLGLATDLG EQLRTLITVP LFHVTGCNSQ LLTAARLGGV AVILPALDLD
QALVTLLAER ISLLVTVPAV YSLLLRHKDF GAADVSGVRQ VCYGGAPIAP SLVRRVKEAF
PRATVLNGYG MTESASLMTV LPDPEAVEHA DSVGYAVPSV DLGVIPLRDG GTGPGELVGE
LVVRGANVTA GYWNRPEATS ATIVDGWLHT GDVVRVDDAG RVHVIDRLKD IINRGGENVS
SVEVESVLLS APSIADACVL AVPDEVMGEK VGAVLFGGAD PIDVAAVLQH CRAQLADFKV
PQYVTVVTNP LPRNAGGKLL KAKLREQIQW GAALR
//
