ID B2HL71_MYCMM Unreviewed; 546 AA.
AC B2HL71;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Tryptophan halogenase {ECO:0000313|EMBL:ACC42047.1};
GN OrderedLocusNames=MMAR_3632 {ECO:0000313|EMBL:ACC42047.1};
OS Mycobacterium marinum (strain ATCC BAA-535 / M).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium ulcerans group.
OX NCBI_TaxID=216594 {ECO:0000313|EMBL:ACC42047.1, ECO:0000313|Proteomes:UP000001190};
RN [1] {ECO:0000313|EMBL:ACC42047.1, ECO:0000313|Proteomes:UP000001190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-535 / M {ECO:0000313|Proteomes:UP000001190};
RX PubMed=18403782; DOI=10.1101/gr.075069.107;
RA Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT "Insights from the complete genome sequence of Mycobacterium marinum on the
RT evolution of Mycobacterium tuberculosis.";
RL Genome Res. 18:729-741(2008).
CC -!- SIMILARITY: Belongs to the flavin-dependent halogenase family.
CC Bacterial tryptophan halogenase subfamily.
CC {ECO:0000256|ARBA:ARBA00038396}.
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DR EMBL; CP000854; ACC42047.1; -; Genomic_DNA.
DR RefSeq; WP_012395255.1; NC_010612.1.
DR AlphaFoldDB; B2HL71; -.
DR STRING; 216594.MMAR_3632; -.
DR KEGG; mmi:MMAR_3632; -.
DR eggNOG; COG0665; Bacteria.
DR HOGENOM; CLU_022247_0_0_11; -.
DR OrthoDB; 8868802at2; -.
DR Proteomes; UP000001190; Chromosome.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR006905; Flavin_halogenase.
DR InterPro; IPR033856; Trp_halogen.
DR PANTHER; PTHR43747; FAD-BINDING PROTEIN; 1.
DR PANTHER; PTHR43747:SF4; FLAVIN-DEPENDENT TRYPTOPHAN HALOGENASE; 1.
DR Pfam; PF04820; Trp_halogenase; 1.
DR PIRSF; PIRSF011396; Trp_halogenase; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR011396-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR011396-2};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR011396-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001190}.
FT ACT_SITE 80
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-1"
FT BINDING 14..17
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 80
FT /ligand="7-chloro-L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:58713"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 349
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 358
FT /ligand="L-tryptophan"
FT /ligand_id="ChEBI:CHEBI:57912"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
FT BINDING 362
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR011396-2"
SQ SEQUENCE 546 AA; 62027 MW; 96DCABBB6C872330 CRC64;
MDDNLIKKVV VLGGGTAGWM TAAYLGKALQ GNVEITVLEA PSVPRIGVGE ATVPNLQRVV
FDFLGIPEDE WMRECNASFK TAVKFINWRT PGEGSPVARH WQGRPDHFYH PFGLLPSPQH
IPLSHFWARN QLKGGTSEPF DYACFREPAI MDAMKAPRYL DGTQATYYAW HFDAALVADF
LRRFATKNLG VVHVQEKMTL AEKDSNGYIT ALRTEEGRRL DGDLFVDCSG FRGLLINEAM
NEPFIDMNDH LLCDSAVATP IRHDDAANGI EPYTSAIAMK SGWTWRTPLL GRFGSGYVYS
SQFASQDEAI RDFCNLWQLD PEDTPLNKIR FRVGRNRRSW VKNVVSVGLS SCFLEPLEST
GIFLIYAALY QLAKHFPDRR FDPVLIDRFN RKIDTLFDET RDFLQAHFYF SPRTDTEFWR
ANKELTLTDS IKEKVAMYKA GVPVNPPIAT ESSYYSNFDA EFENFWTNGS YYCIFAGLGV
LPDHTLPAIN YQSEAIHEAD ALFLDVKQKQ RHLVETLPSN YEYLLKLHGK DMEPNDPMEP
EVTFVA
//
