ID B2HLN6_MYCMM Unreviewed; 587 AA.
AC B2HLN6;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Oxalyl-CoA decarboxylase OxcA {ECO:0000313|EMBL:ACC38785.1};
GN Name=oxcA {ECO:0000313|EMBL:ACC38785.1};
GN OrderedLocusNames=MMAR_0318 {ECO:0000313|EMBL:ACC38785.1};
OS Mycobacterium marinum (strain ATCC BAA-535 / M).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium ulcerans group.
OX NCBI_TaxID=216594 {ECO:0000313|EMBL:ACC38785.1, ECO:0000313|Proteomes:UP000001190};
RN [1] {ECO:0000313|EMBL:ACC38785.1, ECO:0000313|Proteomes:UP000001190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-535 / M {ECO:0000313|Proteomes:UP000001190};
RX PubMed=18403782; DOI=10.1101/gr.075069.107;
RA Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT "Insights from the complete genome sequence of Mycobacterium marinum on the
RT evolution of Mycobacterium tuberculosis.";
RL Genome Res. 18:729-741(2008).
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
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DR EMBL; CP000854; ACC38785.1; -; Genomic_DNA.
DR RefSeq; WP_012392304.1; NC_010612.1.
DR AlphaFoldDB; B2HLN6; -.
DR STRING; 216594.MMAR_0318; -.
DR KEGG; mmi:MMAR_0318; -.
DR eggNOG; COG0028; Bacteria.
DR HOGENOM; CLU_013748_3_3_11; -.
DR OrthoDB; 4494979at2; -.
DR Proteomes; UP000001190; Chromosome.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0008949; F:oxalyl-CoA decarboxylase activity; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR GO; GO:0033611; P:oxalate catabolic process; IEA:InterPro.
DR CDD; cd02004; TPP_BZL_OCoD_HPCL; 1.
DR CDD; cd07035; TPP_PYR_POX_like; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR045025; HACL1-like.
DR InterPro; IPR017660; Oxalyl-CoA_decarboxylase.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR NCBIfam; TIGR03254; oxalate_oxc; 1.
DR PANTHER; PTHR43710; 2-HYDROXYACYL-COA LYASE; 1.
DR PANTHER; PTHR43710:SF2; 2-HYDROXYACYL-COA LYASE 1; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001190};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 20..134
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 211..340
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 413..556
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 587 AA; 61084 MW; C8C1D725256C4BEC CRC64;
MTTQSASPSD ATAAGGLTDG FHLVADALKA NDVATIYGIV GIPITDLART VQARGIRYIG
FRHEASAANA AAAAGFLTAR PGVCLTTSGP GFLNALPALA NATANCFPMI QISGSSQRAI
VDLARGDYQE IDQLNAARPF AKAAYRINRV EDVGLGIARA LRTAISGRPG GVYLDVPGEV
LGQAMDATAA AATVWRLVDP APRQLPAPEA VDRALTILSQ AQRPLIVLGK GAAYAQADNA
IRDFIETTGI PFLPMSMAKG LLPDSHPCSA GAARSLAIAR ADAVLLIGAR LNWLLGHGES
PQWSADAKFI QVDIAASEFD SNRPIAAPLT GDIGSVMAAL SDGLARHPIA TRAPWTTELA
ERKARNEAKM LQRLAEDPHP MRFYNALGAI RTVLHDNPDV YVVNEGANAL DLARNVIDMQ
LPRHRIDTGT WGVMGIGMGY SIAAAVETGR PVVAIEGDSA FGFSGMEVET ICRYQLPVTV
VILNNGGVYR GDEATKAQAT DASPNDPAPT VLSAHARHEL IAEAFGGKGY HVTTPTELRS
ALTAALASNG PTVIDCELDP AAGVESGHLA SLNPSSAATP ARVSAGG
//