ID B2HMF3_MYCMM Unreviewed; 719 AA.
AC B2HMF3;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 24-JAN-2024, entry version 68.
DE SubName: Full=Adenylate or guanylate cyclase {ECO:0000313|EMBL:ACC42173.1};
GN OrderedLocusNames=MMAR_3757 {ECO:0000313|EMBL:ACC42173.1};
OS Mycobacterium marinum (strain ATCC BAA-535 / M).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium ulcerans group.
OX NCBI_TaxID=216594 {ECO:0000313|EMBL:ACC42173.1, ECO:0000313|Proteomes:UP000001190};
RN [1] {ECO:0000313|EMBL:ACC42173.1, ECO:0000313|Proteomes:UP000001190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-535 / M {ECO:0000313|Proteomes:UP000001190};
RX PubMed=18403782; DOI=10.1101/gr.075069.107;
RA Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT "Insights from the complete genome sequence of Mycobacterium marinum on the
RT evolution of Mycobacterium tuberculosis.";
RL Genome Res. 18:729-741(2008).
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC {ECO:0000256|ARBA:ARBA00005381}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000854; ACC42173.1; -; Genomic_DNA.
DR AlphaFoldDB; B2HMF3; -.
DR STRING; 216594.MMAR_3757; -.
DR KEGG; mmi:MMAR_3757; -.
DR eggNOG; COG2114; Bacteria.
DR eggNOG; COG5000; Bacteria.
DR HOGENOM; CLU_015967_0_0_11; -.
DR OMA; KWAILTE; -.
DR Proteomes; UP000001190; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR PANTHER; PTHR45655:SF13; SOLUBLE GUANYLATE CYCLASE GCY-32-RELATED; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF00672; HAMP; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00304; HAMP; 1.
DR SUPFAM; SSF158472; HAMP domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50885; HAMP; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001190};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 454..506
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 546..673
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 719 AA; 78613 MW; 20EB7922996A8FAA CRC64;
MVEGAPAHDG AKGTRRRRPR FRVSIQSKLM VLLLLSSIVS VAAIVAVGFH TGRSSLSAAA
YGRLTQLRES QLRAVETLFS DLTNSLVIYA RGLTVIDAVA QFTAGFDQLA DATISPAQQE
SLVNYYNDQL IKPVEHLTGT KLDLEALLPT SPAQKYLQAY YTAPFTSDQD SMRLDDAGDG
SAWSAANAEF NGYFREIVTR FDYDDAVLLD TRGNIVYSLS KDPDLGTNIL TGPYRESNLR
DAYLRALGAN AVDFTWITDF EPYQPQLDAA TAWLVSPVLQ GGRTEGVLAL PLPIAKINKM
MTADKNWQAA GMGTGTETYL AGPDNLMRSD SRLFLQDPEE YRRQAVAAGT SPEVVNRAIQ
LGSTVLLQPV ATAGLREAQR GQTGTVSAVD YTGNRELEAF APLNIPNSDL HWSILATNDD
SAAFAAAAAF SKALVLVTVA MIVIICVFSM LIAQLMVRPI RRLEAGTEKI SGGDYDVAIP
VKSRDEIGDL TAAFNEMSRS LNIKEDLLNE QRRENDRLLL SMMPEPVVQR YREGEQTIAQ
EHQDVTVIFA DILGLDEVSR SLSGNELIAI VDDLFRQFDS AAESLGVERI RTLHNGYLAS
CGVTTPRLDN VARTVAFALE MQRIIERFNH QSGHQLRLRA GINTGNVISG LVGRTSVVYD
MWGAAVSTAY QMHSGSPQPG IYVTSQVYEA MRDERQFAPA GTIAVGGAEQ QIYRMSEQS
//