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Database: UniProt
Entry: B2HMF3_MYCMM
LinkDB: B2HMF3_MYCMM
Original site: B2HMF3_MYCMM 
ID   B2HMF3_MYCMM            Unreviewed;       719 AA.
AC   B2HMF3;
DT   10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT   10-JUN-2008, sequence version 1.
DT   24-JAN-2024, entry version 68.
DE   SubName: Full=Adenylate or guanylate cyclase {ECO:0000313|EMBL:ACC42173.1};
GN   OrderedLocusNames=MMAR_3757 {ECO:0000313|EMBL:ACC42173.1};
OS   Mycobacterium marinum (strain ATCC BAA-535 / M).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium ulcerans group.
OX   NCBI_TaxID=216594 {ECO:0000313|EMBL:ACC42173.1, ECO:0000313|Proteomes:UP000001190};
RN   [1] {ECO:0000313|EMBL:ACC42173.1, ECO:0000313|Proteomes:UP000001190}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-535 / M {ECO:0000313|Proteomes:UP000001190};
RX   PubMed=18403782; DOI=10.1101/gr.075069.107;
RA   Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA   Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA   Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA   Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA   Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA   Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT   "Insights from the complete genome sequence of Mycobacterium marinum on the
RT   evolution of Mycobacterium tuberculosis.";
RL   Genome Res. 18:729-741(2008).
CC   -!- SIMILARITY: Belongs to the adenylyl cyclase class-3 family.
CC       {ECO:0000256|ARBA:ARBA00005381}.
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DR   EMBL; CP000854; ACC42173.1; -; Genomic_DNA.
DR   AlphaFoldDB; B2HMF3; -.
DR   STRING; 216594.MMAR_3757; -.
DR   KEGG; mmi:MMAR_3757; -.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG5000; Bacteria.
DR   HOGENOM; CLU_015967_0_0_11; -.
DR   OMA; KWAILTE; -.
DR   Proteomes; UP000001190; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd06225; HAMP; 1.
DR   Gene3D; 6.10.340.10; -; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR003660; HAMP_dom.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR   PANTHER; PTHR45655:SF13; SOLUBLE GUANYLATE CYCLASE GCY-32-RELATED; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00672; HAMP; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00304; HAMP; 1.
DR   SUPFAM; SSF158472; HAMP domain-like; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50885; HAMP; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001190};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        433..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          454..506
FT                   /note="HAMP"
FT                   /evidence="ECO:0000259|PROSITE:PS50885"
FT   DOMAIN          546..673
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   719 AA;  78613 MW;  20EB7922996A8FAA CRC64;
     MVEGAPAHDG AKGTRRRRPR FRVSIQSKLM VLLLLSSIVS VAAIVAVGFH TGRSSLSAAA
     YGRLTQLRES QLRAVETLFS DLTNSLVIYA RGLTVIDAVA QFTAGFDQLA DATISPAQQE
     SLVNYYNDQL IKPVEHLTGT KLDLEALLPT SPAQKYLQAY YTAPFTSDQD SMRLDDAGDG
     SAWSAANAEF NGYFREIVTR FDYDDAVLLD TRGNIVYSLS KDPDLGTNIL TGPYRESNLR
     DAYLRALGAN AVDFTWITDF EPYQPQLDAA TAWLVSPVLQ GGRTEGVLAL PLPIAKINKM
     MTADKNWQAA GMGTGTETYL AGPDNLMRSD SRLFLQDPEE YRRQAVAAGT SPEVVNRAIQ
     LGSTVLLQPV ATAGLREAQR GQTGTVSAVD YTGNRELEAF APLNIPNSDL HWSILATNDD
     SAAFAAAAAF SKALVLVTVA MIVIICVFSM LIAQLMVRPI RRLEAGTEKI SGGDYDVAIP
     VKSRDEIGDL TAAFNEMSRS LNIKEDLLNE QRRENDRLLL SMMPEPVVQR YREGEQTIAQ
     EHQDVTVIFA DILGLDEVSR SLSGNELIAI VDDLFRQFDS AAESLGVERI RTLHNGYLAS
     CGVTTPRLDN VARTVAFALE MQRIIERFNH QSGHQLRLRA GINTGNVISG LVGRTSVVYD
     MWGAAVSTAY QMHSGSPQPG IYVTSQVYEA MRDERQFAPA GTIAVGGAEQ QIYRMSEQS
//
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