ID B2HMX4_MYCMM Unreviewed; 960 AA.
AC B2HMX4;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Conserved transmembrane transport protein MmpL3 {ECO:0000313|EMBL:ACC38913.1};
GN Name=mmpL3 {ECO:0000313|EMBL:ACC38913.1};
GN OrderedLocusNames=MMAR_0446 {ECO:0000313|EMBL:ACC38913.1};
OS Mycobacterium marinum (strain ATCC BAA-535 / M).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium ulcerans group.
OX NCBI_TaxID=216594 {ECO:0000313|EMBL:ACC38913.1, ECO:0000313|Proteomes:UP000001190};
RN [1] {ECO:0000313|EMBL:ACC38913.1, ECO:0000313|Proteomes:UP000001190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-535 / M {ECO:0000313|Proteomes:UP000001190};
RX PubMed=18403782; DOI=10.1101/gr.075069.107;
RA Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT "Insights from the complete genome sequence of Mycobacterium marinum on the
RT evolution of Mycobacterium tuberculosis.";
RL Genome Res. 18:729-741(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
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DR EMBL; CP000854; ACC38913.1; -; Genomic_DNA.
DR RefSeq; WP_012392421.1; NC_010612.1.
DR AlphaFoldDB; B2HMX4; -.
DR SMR; B2HMX4; -.
DR STRING; 216594.MMAR_0446; -.
DR KEGG; mmi:MMAR_0446; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_8_0_11; -.
DR OrthoDB; 7051771at2; -.
DR Proteomes; UP000001190; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001190};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..34
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 196..229
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 290..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 402..424
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 566..586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..612
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 624..643
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 678..695
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 62..360
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT DOMAIN 431..744
FT /note="Membrane transport protein MMPL"
FT /evidence="ECO:0000259|Pfam:PF03176"
FT REGION 756..960
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..838
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 849..877
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..896
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 960 AA; 102059 MW; 0822F204CBB52AB7 CRC64;
MFAWWGRTVY RYRFIVIGVT VALCLGGGVF GLSLGKHVTQ SGFYDEGSQS VTASILGDEV
YGRDRTGHIV AVFKAPDGKT VNDPAWSKKI TDQLNQFVKD HPDQVLGWAG YLRAPDSTSP
VIKGMATDDK KYTFVSIPLK GDDDDTILNN YKDIAPSLQK LDGGTVQLAG LEPVAEGLTG
TIATDQRRME VLALPLVAVV LFLVFGGAVA ACLPVMVGGL SIAGALGILR LVAVFGPVHF
FAQPVVSLIG LGIAVDYGLF VVSRFREEIA EGYDTETAVR RTVMTAGRTV AFSAVLIMAS
GASLLMLPQG FVKSLTYALL AAVGLAALLS ITLLPACLGV LGRHVDALGV RTAFRVPFLR
NWKVSRAYLN WLADRLQKTK TREEVEAGFW GNLTNRVMRR PLVFAIPIVL GMILLVIPLF
NLSLGGMSEK YLPPNNAVRQ SQEHFDQLFP GYRTNPLTLV IKSTNNQPVT DQQIADIRSK
AMSISGFIDQ DNDADSMWQE RSYAPGGSKD PSVRVLQNGL INPGDAPTKL AELRAITPPK
GLEIFVGGTP ALEQDSIHSL FENMPAMLVI LLTTTTLLMF LAFGSVVLPI KAAVMSALTL
GSTMGILTWI FVDGHGSGVL NFTATPLTAP VIALVVAVGY GLATDYEVFL VSRMVEAREN
GMSTQEAIRI GTATTGRLIT AAALVLAVVA GSFVFSDLVM MKYLAFGLMA ALLLDATVVR
MFLVPSVMKL LGDDCWWAPR WMRRLQTRIG LGEIQLPDER KRPANNGSAR PPVKAALAAA
TARAPHDPTH PSAPEAARPS RSGGPARTEL GSAQSGPSSA GTKEIQTRAS QPSDPPTTRL
TAPGAPPARG SSNPAPPAQT RPTTPAPPAP APPPAPSAGQ TRAMQIPTNR SSDTGGDPAD
PTAALPIQRP EGTDTEAATE QLNARGGQPD GGENPRPRRR GAGGAGGLSA QDLLRREGRL
//
