ID B2HNE1_MYCMM Unreviewed; 393 AA.
AC B2HNE1;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Chalcone/stilbene synthase {ECO:0000313|EMBL:ACC40639.1};
GN OrderedLocusNames=MMAR_2190 {ECO:0000313|EMBL:ACC40639.1};
OS Mycobacterium marinum (strain ATCC BAA-535 / M).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium ulcerans group.
OX NCBI_TaxID=216594 {ECO:0000313|EMBL:ACC40639.1, ECO:0000313|Proteomes:UP000001190};
RN [1] {ECO:0000313|EMBL:ACC40639.1, ECO:0000313|Proteomes:UP000001190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-535 / M {ECO:0000313|Proteomes:UP000001190};
RX PubMed=18403782; DOI=10.1101/gr.075069.107;
RA Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT "Insights from the complete genome sequence of Mycobacterium marinum on the
RT evolution of Mycobacterium tuberculosis.";
RL Genome Res. 18:729-741(2008).
RN [2] {ECO:0007829|PDB:7CB3}
RP X-RAY CRYSTALLOGRAPHY (2.31 ANGSTROMS).
RA Pratap S., Kant A., Saxena P., Krishnan V.;
RT "Crystal structure of type III polyketide synthase from Mycobacterium
RT marinum.";
RL Submitted (JUN-2020) to the PDB data bank.
RN [3] {ECO:0007829|PDB:7D41}
RP X-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS).
RA Pratap S., Kant A., Saxena P., Krishnan V.;
RT "crystal structure of type III polyketide synthase from Mycobacterium
RT marinum.";
RL Submitted (SEP-2020) to the PDB data bank.
CC -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005194}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531}.
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DR EMBL; CP000854; ACC40639.1; -; Genomic_DNA.
DR RefSeq; WP_012393954.1; NC_010612.1.
DR PDB; 7CB3; X-ray; 2.31 A; A/B=1-393.
DR PDB; 7D41; X-ray; 2.42 A; A/B=1-393.
DR AlphaFoldDB; B2HNE1; -.
DR SMR; B2HNE1; -.
DR STRING; 216594.MMAR_2190; -.
DR KEGG; mmi:MMAR_2190; -.
DR eggNOG; COG3424; Bacteria.
DR HOGENOM; CLU_034992_0_1_11; -.
DR OrthoDB; 9786288at2; -.
DR UniPathway; UPA00094; -.
DR Proteomes; UP000001190; Chromosome.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR PANTHER; PTHR11877:SF46; TYPE III POLYKETIDE SYNTHASE A; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:7CB3, ECO:0007829|PDB:7D41};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000001190}.
FT DOMAIN 33..235
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 250..389
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 175
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 393 AA; 42335 MW; 9487235DF197519F CRC64;
MSTAAEGGAI RRAGHEPRYD LAQLPPAPPT TVAVIEGMAT GAPQRVVAQA DAAARVSELF
VDPQQRERIS RIYDKTRIDT RRMAVDPLDD EFDEFRREPA TIRDRMNLFY QHAVPLAVDV
AARALDGLPY APDEIGQLVF VTSTGFIAPG VDVEIVKQLG LPRSISRVVV NFMGCAAAMN
AIRTATNYVR AHPSMKALVV CIELSSVNAV FADDINDVVI HSLFGDGCGA LVIGASQVQQ
PLPAGNVVIR SSFSQLLDDS EDGIVLGVNH DGITCELSEN LPSYIYRSVD PVVAEMLRDN
GLSKADIDLW AIHPGGPKII EQSARSLGIP VGRAVQSWDV LAQFGNMLSV SLIFVLEMMV
AQAESDKPIS TGVAFAFAPG VTVEGMLFDI IRR
//
