ID B2HPZ5_MYCMM Unreviewed; 767 AA.
AC B2HPZ5;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 24-JAN-2024, entry version 74.
DE RecName: Full=Serine/threonine-protein kinase PknG {ECO:0000256|ARBA:ARBA00014676};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=pknG {ECO:0000313|EMBL:ACC39172.1};
GN OrderedLocusNames=MMAR_0713 {ECO:0000313|EMBL:ACC39172.1};
OS Mycobacterium marinum (strain ATCC BAA-535 / M).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium ulcerans group.
OX NCBI_TaxID=216594 {ECO:0000313|EMBL:ACC39172.1, ECO:0000313|Proteomes:UP000001190};
RN [1] {ECO:0000313|EMBL:ACC39172.1, ECO:0000313|Proteomes:UP000001190}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-535 / M {ECO:0000313|Proteomes:UP000001190};
RX PubMed=18403782; DOI=10.1101/gr.075069.107;
RA Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT "Insights from the complete genome sequence of Mycobacterium marinum on the
RT evolution of Mycobacterium tuberculosis.";
RL Genome Res. 18:729-741(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR EMBL; CP000854; ACC39172.1; -; Genomic_DNA.
DR RefSeq; WP_012392663.1; NC_010612.1.
DR AlphaFoldDB; B2HPZ5; -.
DR STRING; 216594.MMAR_0713; -.
DR KEGG; mmi:MMAR_0713; -.
DR eggNOG; COG0515; Bacteria.
DR HOGENOM; CLU_011707_0_0_11; -.
DR OMA; PHCGSAY; -.
DR OrthoDB; 137117at2; -.
DR Proteomes; UP000001190; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14014; STKc_PknB_like; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR031634; PknG_rubred.
DR InterPro; IPR031636; PknG_TPR.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR24363; SERINE/THREONINE PROTEIN KINASE; 1.
DR PANTHER; PTHR24363:SF0; SERINE/THREONINE-PROTEIN KINASE DDB_G0277989-RELATED; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF16919; PknG_rubred; 1.
DR Pfam; PF16918; PknG_TPR; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:ACC39172.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001190};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 168..410
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 767 AA; 83291 MW; 5E332B1D161AB1E2 CRC64;
MAEAVKKGLQ DTSGTENPRP AEDEQEAGPG TQPADVQTGA AAWSRPIGTQ ALFRPNFDDD
DEDDITLGTL DMQPQGPLAA ATRARLPVRR LGGGLVEIPR VPDTDPLKAL MTDPVVPEAK
RFCWNCGRPV GRSDSETKGA SEGWCPYCGS PYSFLPQLSP GDTIAGQYEV KGCIAHGGMG
WIYLALDRNV NDRPVVLKGL VHSGDAEAQA IAMAERQFLA EVVHPSIVQI FNFVEHTDKH
GDPVGYIVME YVGGRSLKRR KGEKLPVSEA IAYLLEILPA LAYLHALGLV YNDLKPENIM
LTEEQLKLID LGAVSRINSF GYLYGTPGFQ APEIVRTGPT VATDIYTVGR TLAALTLNLP
TRNGRYLDGL PDDDPVLASY DSFGRLLRRA IDPDPRRRFA SAEEMSGQLM GVLREVVAQD
TGVPRPGLST VFSPSRSTFG VDLLVAHTDV YQDGQVHSEK LTAKEIVTAL QVPLVDRTDV
AASVLQATVL SQPVQTLDSL RAARHGALDS DGADLSESVE LPLMEVRALL DLGDVAKATR
KLDDLSERVG WRWRLVWYRA VSELLTGAYD AAIKHFTEVL DTFPGELAPK LALAATAELA
GYTDGTNFYQ TVWSTNDGVI SAAFGLARTL SAQGERAGAV RTLDEVPPSS RHFTTARLTS
AVTLLSGRSH GEITEEQIRD AARRVEALPP TEPRVLQIRA LVLGGAMDWL QDNEASTNHI
LGFPFTDHGL RLGVEASLRS LARVAPTQRH RYTLVDMANK VRPTSTF
//