ID MUTL_NOSP7 Reviewed; 568 AA.
AC B2IYW1;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=Npun_F3251;
OS Nostoc punctiforme (strain ATCC 29133 / PCC 73102).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=63737;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29133 / PCC 73102;
RX PubMed=23463784; DOI=10.1104/pp.112.213116;
RA Ekman M., Picossi S., Campbell E.L., Meeks J.C., Flores E.;
RT "A Nostoc punctiforme Sugar Transporter Necessary to Establish a
RT Cyanobacterium-Plant Symbiosis.";
RL Plant Physiol. 161:1984-1992(2013).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR EMBL; CP001037; ACC81694.1; -; Genomic_DNA.
DR RefSeq; WP_012409673.1; NC_010628.1.
DR AlphaFoldDB; B2IYW1; -.
DR SMR; B2IYW1; -.
DR STRING; 63737.Npun_F3251; -.
DR EnsemblBacteria; ACC81694; ACC81694; Npun_F3251.
DR KEGG; npu:Npun_F3251; -.
DR eggNOG; COG0323; Bacteria.
DR HOGENOM; CLU_004131_4_1_3; -.
DR OrthoDB; 9763467at2; -.
DR PhylomeDB; B2IYW1; -.
DR Proteomes; UP000001191; Chromosome.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Reference proteome.
FT CHAIN 1..568
FT /note="DNA mismatch repair protein MutL"
FT /id="PRO_1000096667"
SQ SEQUENCE 568 AA; 63655 MW; 55A2B4C38EB66E25 CRC64;
MASIIQALPT EVVYLITAGE VIDSLASVVR ELVENSLDAG ATRIVVSLWP QQWRIRVADN
GCGMNLDDLQ QAATAHSTSK IRSSADLWKI NSLGFRGEAL HSLTTLADLE ILSRPVDGKL
GWRISYGNGG KVVQVEVTAI APGTVVTVSN LFGNCSSRRQ GLPTTAQQMK AVQATIYQIA
LCHPHVTWQI WQNDRQWFTI SPARTTGQLL PQILPQVRQG DLQEVKLEIP NPPHSPLPCT
NAIHRVSPHS ALTLVVGLPD RCHRHRPDWV RVAINGRMVK TPELEQTILS AFHRTLPRDR
YPICFLHLAI SPDQINWNRN PAKTEIYLNE IIYWQEQITQ AINQALSISS SNLKEAVHTT
RVSKLLKAAE AKGGYNFNPQ NPKEDRKNPN SLKAVAQVSN TYIVAEHPGG MWLVEQHIAH
ERVLYEQLCD DWQLVPVEPP IILYQLSLAQ VSQLQRIGLD IESFGEQLWA VRNIPAPLQQ
RDDCAEAILE LSWGGDLQTA QVAVACRSAI RNGTPMNQQE MQTLLDNWQR TRNPRTCPHG
RPIYLSLEES ALARFFRRNW VIGKSHGI
//
