ID   B2JMD1_PARP8            Unreviewed;      1227 AA.
AC   B2JMD1;
DT   10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT   10-JUN-2008, sequence version 1.
DT   27-MAR-2024, entry version 76.
DE   SubName: Full=Adenylate/guanylate cyclase {ECO:0000313|EMBL:ACC74266.1};
GN   OrderedLocusNames=Bphy_5181 {ECO:0000313|EMBL:ACC74266.1};
OS   Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 /
OS   STM815) (Burkholderia phymatum).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=391038 {ECO:0000313|EMBL:ACC74266.1, ECO:0000313|Proteomes:UP000001192};
RN   [1] {ECO:0000313|Proteomes:UP000001192}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 17167 / CIP 108236 / LMG 21445 / STM815
RC   {ECO:0000313|Proteomes:UP000001192};
RX   PubMed=25197461; DOI=10.4056/sigs.4861021;
RA   Moulin L., Klonowska A., Caroline B., Booth K., Vriezen J.A., Melkonian R.,
RA   James E.K., Young J.P., Bena G., Hauser L., Land M., Kyrpides N., Bruce D.,
RA   Chain P., Copeland A., Pitluck S., Woyke T., Lizotte-Waniewski M.,
RA   Bristow J., Riley M.;
RT   "Complete genome sequence of Burkholderia phymatum STM815(T), a broad host
RT   range and efficient nitrogen-fixing symbiont of Mimosa species.";
RL   Stand. Genomic Sci. 9:763-774(2014).
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DR   EMBL; CP001044; ACC74266.1; -; Genomic_DNA.
DR   AlphaFoldDB; B2JMD1; -.
DR   STRING; 391038.Bphy_5181; -.
DR   KEGG; bph:Bphy_5181; -.
DR   eggNOG; COG0457; Bacteria.
DR   eggNOG; COG2114; Bacteria.
DR   eggNOG; COG3899; Bacteria.
DR   HOGENOM; CLU_004435_3_1_4; -.
DR   Proteomes; UP000001192; Chromosome 2.
DR   GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   CDD; cd09487; SAM_superfamily; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR041664; AAA_16.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR16305:SF28; ADENYLATE CYCLASE 10; 1.
DR   PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR   Pfam; PF13191; AAA_16; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   SMART; SM00044; CYCc; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   4: Predicted;
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001192}.
FT   DOMAIN          20..65
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          113..246
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   1227 AA;  135584 MW;  9888CAA03F9DF5E1 CRC64;
     MDKLRRRADD NFGWVPQRST MTDDLTTWLA QIGLGAYAAK FISQGIDWDV LSDLSEGDLK
     ELGLTLGDRK RLAKGLAALN GVHTRSRQQA EQCGRLPSSS APEAVDAERR QITVMFIDLI
     DSTALAERFD PEDMRRLLGF YHQACARAIE AHEGHIALYI GDGLLVYFGY PNAHEDDAIR
     AVLAALAAIA ALREANELVE TQYGVRLQAR IGIETGLVVA GAIGAGSSLD HRAIVGEAPI
     IAARLQSLAP PDAIVVGPTV QRLIEGSFEL ENLGWRELKG VTGPVRVQRV LAQADTIDRF
     EIRAIHGVTP LVGRAAELDM IRRRWKQSVD GEMRCVLLTG EPGIGKFRLL RALCEDMSQD
     AHSMVSLHCS AYYRNSPFWP VQRWLQRTFG IVPDASDASK LERLEAGVAT PGVDVDEALL
     VLTNLLGIPA GTRHPGIDTS SPSFKRRTLD LLVAMIETST HVQPLLVVVE DAHWMDPSSL
     EFVRLVVEQL MSARLMVVIT ARPDFEPGWT YPHLVQLNLD RLSRCECVAM IERLTGGKQL
     PDLVRNQIVS KTDGVPLFVE ELTKAILQSD LLEDAGIGYT LKGTPQEIAI PDTLQGSLLS
     RLDRLEPVVK ETAQLAATVG REFGRKLLGL IASRSEDELQ ESLDRLIGAE IIVPASGKFA
     GEDAYLFRHA LIQEIAYQSL LLARRRHYHA LIAAALEEHY PETVERQPEL IAQNFVAADL
     PDRAIGYWQR AGERALAGAA YDETIAHVQR GLELINRCAC NEPDRARHLL SLLLTRGRAE
     LRLAQREAIA TFREAARIAR EQKLTSYLVQ AALEFDTAET FLEGSGDESL SLLKEALTVI
     GTEESLERCR LLSRLVRTVH MTGACEQSSG FAEEAIALAR RLNDLPSLFD ALACELMHVG
     ALPLPANRFP ERQSVLMELM QMAEDLGDAH TIGHACARCL AGYLEIGEAD RFESALERYR
     QIATSGQHFV DKWCVTGAQA MRAILVGDFS EAEHKTRDSL QMAQNADANL ATGVYGMQMF
     AIRREQGRLA EVAPIFKRFV DEHAADATWR PGFMLICSDL GFEAQARDNL VQLEESESGI
     PVDSKRLVTL TYLAEVAARL REVEHAERIY ALLLPFQDQV VTVPVFTLCC GSAARFLGML
     ARALGDWSAA ERHFEYALTM DERLRAWPWL AHGRYEYALM LAARNGIGDK TRAQHLLSMA
     AATARQLKMF ALVERIAGAQ TGTGLRS
//