ID B2JMY2_PARP8 Unreviewed; 411 AA.
AC B2JMY2;
DT 10-JUN-2008, integrated into UniProtKB/TrEMBL.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=DNA topoisomerase {ECO:0000256|ARBA:ARBA00012891};
DE EC=5.6.2.1 {ECO:0000256|ARBA:ARBA00012891};
DE Flags: Precursor;
GN OrderedLocusNames=Bphy_5297 {ECO:0000313|EMBL:ACC74375.1};
OS Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 /
OS STM815) (Burkholderia phymatum).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=391038 {ECO:0000313|EMBL:ACC74375.1, ECO:0000313|Proteomes:UP000001192};
RN [1] {ECO:0000313|Proteomes:UP000001192}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17167 / CIP 108236 / LMG 21445 / STM815
RC {ECO:0000313|Proteomes:UP000001192};
RX PubMed=25197461; DOI=10.4056/sigs.4861021;
RA Moulin L., Klonowska A., Caroline B., Booth K., Vriezen J.A., Melkonian R.,
RA James E.K., Young J.P., Bena G., Hauser L., Land M., Kyrpides N., Bruce D.,
RA Chain P., Copeland A., Pitluck S., Woyke T., Lizotte-Waniewski M.,
RA Bristow J., Riley M.;
RT "Complete genome sequence of Burkholderia phymatum STM815(T), a broad host
RT range and efficient nitrogen-fixing symbiont of Mimosa species.";
RL Stand. Genomic Sci. 9:763-774(2014).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-independent breakage of single-stranded DNA, followed by
CC passage and rejoining.; EC=5.6.2.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000213};
CC -!- SIMILARITY: Belongs to the type IB topoisomerase family.
CC {ECO:0000256|ARBA:ARBA00006645}.
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DR EMBL; CP001044; ACC74375.1; -; Genomic_DNA.
DR RefSeq; WP_012404539.1; NZ_CADFGH010000008.1.
DR AlphaFoldDB; B2JMY2; -.
DR STRING; 391038.Bphy_5297; -.
DR KEGG; bph:Bphy_5297; -.
DR eggNOG; COG3569; Bacteria.
DR HOGENOM; CLU_046978_1_1_4; -.
DR OrthoDB; 9778962at2; -.
DR Proteomes; UP000001192; Chromosome 2.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003917; F:DNA topoisomerase type I (single strand cut, ATP-independent) activity; IEA:InterPro.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR Gene3D; 1.10.132.120; -; 1.
DR Gene3D; 3.30.66.10; DNA topoisomerase I domain; 1.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR035447; DNA_topo_I_N_sf.
DR InterPro; IPR049331; Top1B_N_bact.
DR InterPro; IPR001631; TopoI.
DR InterPro; IPR014711; TopoI_cat_a-hlx-sub_euk.
DR InterPro; IPR013500; TopoI_cat_euk.
DR Pfam; PF21338; Top1B_N_bact; 1.
DR Pfam; PF01028; Topoisom_I; 1.
DR PRINTS; PR00416; EUTPISMRASEI.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF55869; DNA topoisomerase I domain; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:ACC74375.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001192};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 46..94
FT /note="DNA topoisomerase IB N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21338"
FT DOMAIN 106..321
FT /note="DNA topoisomerase I catalytic core eukaryotic-type"
FT /evidence="ECO:0000259|Pfam:PF01028"
SQ SEQUENCE 411 AA; 45933 MW; BC2452BB9E9BCE8C CRC64;
MKTMTPGAID AIAQGLASGL SGSLPAGLRH ADDTRPGFSR RKLRRGFAYF DLDGRRIDDE
QQIARINALA IPPAYTDVWI CPDPRGHIQA TGRDARGRKQ YRYHPQWRET RDADKFGRMA
AFGQALPKIR ARVARDLARK GMPREKVIAA VVHLLDTTLI RIGSVEYARD NQSYGLTTLR
KKHVTIRAGE VRFRFAGKSG IEHDVTVDNP RVKRIVRQCA DLPGHELFQY VDEDGARHTI
GSADINDYLR EVSHADFTAK DYRTWAGSVY AMAALRELVC ESATDARRHV VATVKQVATL
LRNTPAVCRR CYIHPEVIAA FEAGELQALR ACRPQRAKRH MKVDEIAFAA LLAQAEKRAR
RAIRGARKDG KTPSAADVEK DIENRRLATL LRKSRALGKQ TSARTRAANT A
//
