ID BETI_PARP8 Reviewed; 196 AA.
AC B2JS87;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=HTH-type transcriptional regulator BetI {ECO:0000255|HAMAP-Rule:MF_00768};
GN Name=betI {ECO:0000255|HAMAP-Rule:MF_00768}; OrderedLocusNames=Bphy_3308;
OS Paraburkholderia phymatum (strain DSM 17167 / CIP 108236 / LMG 21445 /
OS STM815) (Burkholderia phymatum).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Paraburkholderia.
OX NCBI_TaxID=391038;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17167 / CIP 108236 / LMG 21445 / STM815;
RX PubMed=25197461; DOI=10.4056/sigs.4861021;
RA Moulin L., Klonowska A., Caroline B., Booth K., Vriezen J.A., Melkonian R.,
RA James E.K., Young J.P., Bena G., Hauser L., Land M., Kyrpides N., Bruce D.,
RA Chain P., Copeland A., Pitluck S., Woyke T., Lizotte-Waniewski M.,
RA Bristow J., Riley M.;
RT "Complete genome sequence of Burkholderia phymatum STM815(T), a broad host
RT range and efficient nitrogen-fixing symbiont of Mimosa species.";
RL Stand. Genomic Sci. 9:763-774(2014).
CC -!- FUNCTION: Repressor involved in the biosynthesis of the osmoprotectant
CC glycine betaine. It represses transcription of the choline transporter
CC BetT and the genes of BetAB involved in the synthesis of glycine
CC betaine (By similarity). {ECO:0000250}.
CC -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via
CC choline pathway [regulation].
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DR EMBL; CP001044; ACC72464.1; -; Genomic_DNA.
DR RefSeq; WP_012402637.1; NZ_CADFGH010000006.1.
DR AlphaFoldDB; B2JS87; -.
DR SMR; B2JS87; -.
DR STRING; 391038.Bphy_3308; -.
DR KEGG; bph:Bphy_3308; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_069356_15_4_4; -.
DR OrthoDB; 7618612at2; -.
DR UniPathway; UPA00529; -.
DR Proteomes; UP000001192; Chromosome 2.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019285; P:glycine betaine biosynthetic process from choline; IEA:UniProtKB-UniRule.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR HAMAP; MF_00768; HTH_type_BetI; 1.
DR InterPro; IPR039538; BetI_C.
DR InterPro; IPR023772; DNA-bd_HTH_TetR-type_CS.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR036271; Tet_transcr_reg_TetR-rel_C_sf.
DR InterPro; IPR017757; Tscrpt_rep_BetI.
DR NCBIfam; TIGR03384; betaine_BetI; 1.
DR PANTHER; PTHR30055:SF254; HTH-TYPE TRANSCRIPTIONAL REGULATOR BETI; 1.
DR PANTHER; PTHR30055; HTH-TYPE TRANSCRIPTIONAL REGULATOR RUTR; 1.
DR Pfam; PF13977; TetR_C_6; 1.
DR Pfam; PF00440; TetR_N; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF48498; Tetracyclin repressor-like, C-terminal domain; 1.
DR PROSITE; PS01081; HTH_TETR_1; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..196
FT /note="HTH-type transcriptional regulator BetI"
FT /id="PRO_1000133656"
FT DOMAIN 8..68
FT /note="HTH tetR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
FT DNA_BIND 31..50
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00768"
SQ SEQUENCE 196 AA; 21556 MW; 560E0F9B3141A398 CRC64;
MPKVGMREVR RAQLIDATLL TIDQSGLSGT TLASVAQRAN ISTGIVSHYF GDKDGLLEAT
MRHILRDLWA ATTRRRIAAK AQPRARLRAI VAANFDVSQV SGPVMKTWLA FWSESMHEPA
LRRLQHVNTR RLYSNLCAEF AKELPRACAR RAASGLAAMI DGLWLRGALS GDPFDTKAAL
RLANDYIDLL LAQSAA
//
