GenomeNet

Database: UniProt
Entry: B2LW77
LinkDB: B2LW77
Original site: B2LW77 
ID   DLK2_PIG                Reviewed;         383 AA.
AC   B2LW77; F1RRJ8;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 2.
DT   13-FEB-2019, entry version 67.
DE   RecName: Full=Protein delta homolog 2;
DE            Short=DLK-2;
DE   AltName: Full=Epidermal growth factor-like protein 9;
DE            Short=EGF-like protein 9;
DE   Flags: Precursor;
GN   Name=DLK2; Synonyms=EGFL9;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Suina; Suidae;
OC   Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wang J., Yang G.-Y., Li H.-J., Wang Y.-L., Zhao W.-D., Wang W.-J.,
RA   Zhang Z.-Q.;
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Porcine genome sequencing project;
RL   Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Regulates adipogenesis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
DR   EMBL; EU589332; ACB88022.1; -; mRNA.
DR   EMBL; CU928765; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001121938.1; NM_001128466.1.
DR   RefSeq; XP_005666087.1; XM_005666030.2.
DR   RefSeq; XP_005666088.1; XM_005666031.2.
DR   UniGene; Ssc.72165; -.
DR   SMR; B2LW77; -.
DR   STRING; 9823.ENSSSCP00000001830; -.
DR   PaxDb; B2LW77; -.
DR   PRIDE; B2LW77; -.
DR   Ensembl; ENSSSCT00000001877; ENSSSCP00000001830; ENSSSCG00000001682.
DR   GeneID; 100145892; -.
DR   KEGG; ssc:100145892; -.
DR   CTD; 65989; -.
DR   eggNOG; KOG1217; Eukaryota.
DR   eggNOG; KOG1219; Eukaryota.
DR   eggNOG; ENOG410ZHP6; LUCA.
DR   GeneTree; ENSGT00940000160761; -.
DR   HOGENOM; HOG000065685; -.
DR   HOVERGEN; HBG051454; -.
DR   InParanoid; B2LW77; -.
DR   OMA; FHGKDCE; -.
DR   OrthoDB; 880666at2759; -.
DR   TreeFam; TF351835; -.
DR   Proteomes; UP000008227; Chromosome 7.
DR   Bgee; ENSSSCG00000001682; Expressed in 2 organ(s), highest expression level in prefrontal cortex.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   Pfam; PF00008; EGF; 3.
DR   Pfam; PF12661; hEGF; 1.
DR   SMART; SM00181; EGF; 6.
DR   SMART; SM00179; EGF_CA; 4.
DR   PROSITE; PS00010; ASX_HYDROXYL; 2.
DR   PROSITE; PS00022; EGF_1; 6.
DR   PROSITE; PS01186; EGF_2; 6.
DR   PROSITE; PS50026; EGF_3; 6.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   2: Evidence at transcript level;
KW   Calcium; Complete proteome; Disulfide bond; EGF-like domain;
KW   Glycoprotein; Membrane; Reference proteome; Repeat; Signal;
KW   Transmembrane; Transmembrane helix.
FT   SIGNAL        1     26       {ECO:0000255}.
FT   CHAIN        27    383       Protein delta homolog 2.
FT                                /FTId=PRO_0000410796.
FT   TOPO_DOM     27    306       Extracellular. {ECO:0000255}.
FT   TRANSMEM    307    327       Helical. {ECO:0000255}.
FT   TOPO_DOM    328    383       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       27     58       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN       62     89       EGF-like 2. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN       91    129       EGF-like 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      131    172       EGF-like 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      174    210       EGF-like 5; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DOMAIN      212    248       EGF-like 6; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   CARBOHYD    157    157       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     29     40       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID     33     46       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID     48     57       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID     66     71       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID     79     88       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID     95    107       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    101    117       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    119    128       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    135    148       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    142    160       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    162    171       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    178    189       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    183    198       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    200    209       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    216    227       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    221    236       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    238    247       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   CONFLICT     18     18       A -> G (in Ref. 1; ACB88022).
FT                                {ECO:0000305}.
FT   CONFLICT    108    108       I -> V (in Ref. 1; ACB88022).
FT                                {ECO:0000305}.
FT   CONFLICT    250    250       V -> A (in Ref. 1; ACB88022).
FT                                {ECO:0000305}.
FT   CONFLICT    281    281       S -> G (in Ref. 1; ACB88022).
FT                                {ECO:0000305}.
FT   CONFLICT    304    304       K -> E (in Ref. 1; ACB88022).
FT                                {ECO:0000305}.
SQ   SEQUENCE   383 AA;  40622 MW;  C2D8E895BD815605 CRC64;
     MPSGCRCLHL VCLLCILAAP VKPVRADDCS SHCDLAHGCC APDGSCRCDP GWEGLHCERC
     VRMPGCQHGT CHQPWQCICH SGWAGKFCDK DEHVCTTQSP CRNGGQCIYD GGGEYHCVCP
     PGFHGRDCER KEGPCEQAGS PCRNGGQCQD DQGFALNYTC RCLAGFVGAH CEVNVDDCLM
     RPCANGATCL DGINRFSCLC PEGFAGRFCT INLDDCASRP CQRGARCRDR VHDFDCLCPS
     GYGGKTCELV LPVPDPATTA DIPPGPTLAV VVPATGPIPH SAGAGLLRIS VKEVVRRQEA
     GLGKSSLVAV VVFGAVTATL VLSTVLLTLR AWRRGVCPPG PCCYPAPHYA PARQDQECQV
     SMLPAGLPLP PDLPPEPGKT TAL
//
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