ID   B2UFZ8_RALPJ            Unreviewed;      1186 AA.
AC   B2UFZ8;
DT   01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT   01-JUL-2008, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   SubName: Full=Pyruvate ferredoxin/flavodoxin oxidoreductase {ECO:0000313|EMBL:ACD28525.1};
GN   OrderedLocusNames=Rpic_3404 {ECO:0000313|EMBL:ACD28525.1};
OS   Ralstonia pickettii (strain 12J).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=402626 {ECO:0000313|EMBL:ACD28525.1};
RN   [1] {ECO:0000313|EMBL:ACD28525.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=12J {ECO:0000313|EMBL:ACD28525.1};
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA   Bruce D., Goodwin L., Pitluck S., Meincke L., Brettin T., Detter J.C.,
RA   Han C., Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L.,
RA   Kyrpides N., Mikhailova N., Marsh T., Richardson P.;
RT   "Complete sequence of chromosome1 of Ralstonia pickettii 12J.";
RL   Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; CP001068; ACD28525.1; -; Genomic_DNA.
DR   AlphaFoldDB; B2UFZ8; -.
DR   STRING; 402626.Rpic_3404; -.
DR   KEGG; rpi:Rpic_3404; -.
DR   PATRIC; fig|402626.5.peg.4537; -.
DR   eggNOG; COG1014; Bacteria.
DR   eggNOG; COG4231; Bacteria.
DR   HOGENOM; CLU_009166_1_0_4; -.
DR   GO; GO:0016903; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd02008; TPP_IOR_alpha; 1.
DR   CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.920.10; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR   InterPro; IPR046667; DUF6537.
DR   InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   PANTHER; PTHR48084:SF4; 2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORB; 1.
DR   PANTHER; PTHR48084; 2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORB-RELATED; 1.
DR   Pfam; PF20169; DUF6537; 1.
DR   Pfam; PF01558; POR; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   SUPFAM; SSF53323; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Pyruvate {ECO:0000313|EMBL:ACD28525.1}.
FT   DOMAIN          477..626
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
FT   DOMAIN          750..936
FT                   /note="Pyruvate/ketoisovalerate oxidoreductase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01558"
FT   DOMAIN          965..1170
FT                   /note="DUF6537"
FT                   /evidence="ECO:0000259|Pfam:PF20169"
SQ   SEQUENCE   1186 AA;  129741 MW;  EE41279E00F2C86A CRC64;
     MNAPLNDALR RALETVSLDD KYTLERGRIY ISGTQALVRL PMLQQERDRA AGLNTAGFIS
     GYRGSPLGAL DQALWKAKKH LAGHNIVFQA GLNEDLAATA VWGSQQVNLY PSAKFSGVFG
     MWYGKGPGVD RTIDVFKHAN SAGSSAHGGV LVLAGDDHAA KSSTLAHQSE HVFKAAGIPV
     LYPSNVQEYL DYGLHGWAMS RYSGLWVSMK CVTDVVESSA SVDVDPHRAQ IILPEDFAMP
     QGGLNIRWPD PPLVQEARLL DYKWYAGLSY VRANKLDRVV LDSPQARFGI MTAGKAYLDV
     RQALVDLGLD EDTCRRIGIR LYKVGCVWPL EAHGARAFAE GLQEILVVEE KRQILEYQLK
     EELYNYRDDV RPRVYGKFDE KDNAGGEWSV PMANWLLPAH YELSPALIAR AIATRLEKFE
     LPSDVRARIA SRIAIIDAKE KALARPRVTA ERKPWFCSGC PHNTSTNVPE GSRALAGIGC
     HYMTVWMDRR TDTFSQMGGE GVAWIGQMPF SGDQHVFANL GDGTYYHSGL LAIRASIAAK
     VNITYKILYN DAVAMTGGQP VDGPLSVPQI AAQVHAEGTS RIVIVTDEPE KYNAAIKLPE
     GVTVHHRDRL DAIQRELREV QGTSVLIYDQ TCATEKRRRR KRGTLVDPAR RAFINDAVCE
     GCGDCSVKSN CLSVEPLETE LGTKRKINQS SCNKDFSCVN GFCPSFVTAE GAQVRKPESH
     GVSMEGLPLL PHPELPAIQR AYGVLVTGVG GTGVVTIGGL LGMAAHIEGK GVTVLDMAGL
     AQKGGAVLSH VQIGERPDSI HATRIAMGEA DLVIGCDAIV SASDEVLSKV QHGQTRAIVN
     STASPTADFI KNPNWRFPGS STEADIRAAI GDACAFEDAS TLAVRLLGDA IYTNPLVLGF
     AWQKGWLPLT HDALVRAIEL NGVAVEKNKT AFEWGRHLAQ DRDAVLKLAD DAPRAKADVI
     ALPSLDTLIA RRVDLLTAYQ NAAYAAEFRA VVERVRAAEA AVVGAGQALA LTEAVVRNLS
     KLMAYKDEYE VARLYTDPAF LDKLRAQFEG EPGRDYQLNF WLAPPMMAKR DEKGHLVKQR
     FGPNTMRIFK VLAKLKGLRG TAFDIFGKTE ERRTERALIG EYRALIDELV KSLTAQKLAQ
     AVELARLPED IRGFGHVKEA NLAAARIRWN KLLAQWRDPA AAQQAA
//