ID B2UP12_AKKM8 Unreviewed; 1077 AA.
AC B2UP12;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Tetratricopeptide TPR_2 repeat protein {ECO:0000313|EMBL:ACD04382.1};
GN OrderedLocusNames=Amuc_0544 {ECO:0000313|EMBL:ACD04382.1};
OS Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC
OS 81048 / CCUG 64013 / CIP 107961 / Muc).
OC Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC Akkermansiaceae; Akkermansia.
OX NCBI_TaxID=349741 {ECO:0000313|EMBL:ACD04382.1, ECO:0000313|Proteomes:UP000001031};
RN [1] {ECO:0000313|Proteomes:UP000001031}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013
RC / CIP 107961 / Muc {ECO:0000313|Proteomes:UP000001031};
RX PubMed=21390229; DOI=10.1371/journal.pone.0016876;
RA van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M.,
RA Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.;
RT "The genome of Akkermansia muciniphila, a dedicated intestinal mucin
RT degrader, and its use in exploring intestinal metagenomes.";
RL PLoS ONE 6:E16876-E16876(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP001071; ACD04382.1; -; Genomic_DNA.
DR RefSeq; WP_012419597.1; NZ_CP071807.1.
DR AlphaFoldDB; B2UP12; -.
DR PaxDb; 349741-Amuc_0544; -.
DR KEGG; amu:Amuc_0544; -.
DR eggNOG; COG0457; Bacteria.
DR eggNOG; COG1729; Bacteria.
DR HOGENOM; CLU_286631_0_0_0; -.
DR OrthoDB; 198294at2; -.
DR BioCyc; AMUC349741:G1GBX-595-MONOMER; -.
DR Proteomes; UP000001031; Chromosome.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12558; CELL DIVISION CYCLE 16,23,27; 1.
DR PANTHER; PTHR12558:SF13; CELL DIVISION CYCLE PROTEIN 27 HOMOLOG; 1.
DR Pfam; PF13174; TPR_6; 2.
DR Pfam; PF13181; TPR_8; 1.
DR SMART; SM00028; TPR; 4.
DR SUPFAM; SSF48452; TPR-like; 4.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001031};
KW Signal {ECO:0000256|SAM:SignalP};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..1077
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002783688"
FT REPEAT 496..529
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ SEQUENCE 1077 AA; 120829 MW; 26B512EFF44DAC1B CRC64;
MIKSNYTTAL AAGLVSVLSI GAVLPSGAQH GPRDYQRTAL TAIKEGKWQE ALDAVDRCIR
VYEPRIKMLG LDDGFGWFYY QKGVCLAQLK NYKEAVEAFK ACYTKFPSAK NQLVKMALFR
EGENYCRLGD FAKGAELLEK FLKEYRSDPV ARNVNAGEVQ GLLAQCYFKM SPPAFEKGME
NLTSCVTSRY KGRRITDAVI TNGFLAMVDA AIKTGKCSET VKFVENYPSV MNISPTRVAL
YTPRLVSYVA EVLEKSRSLL QDGKQKESED YASLAMVLMG LLPDQSGVMA DANYSLDRLG
RANGAVPGVT DFSHTLDRAK VTALIDQFNK MKEEGKVMDA FTFSFMGNQA LVHGSQRVAR
AAYQLINESY PDAPGREDNL YYLAMTTWQL GEADKGGELV AQHLKEFPNS KYAPMLNTLS
LEGLLKEKKF DLCVQQADKV MELHKDDPTH KFYELALYCK GASLFNLGAA DASRYKEAVP
VLERFVKEYR DSTYLKTAMY LLGETYTNLG NTDEAIRSFT NYIARFPDKG EANMAAVLYD
RAFNYLNRKN PGDEELAAKD AKEIVDNFKD HRLFPYANNL LANLCAGSKE HEQEAEGYFL
AALESAKKLG DKRPAAEAVY NLFINATKKP LPVEPKEAVE TARTARRDEV KKWYDEYWKD
SDQPGSRYSL QLAAAAMDFF KDDKEMFDPA SVKMQEIIVR EGKKDDPKMT VLLEEAVNSY
TKTYMAGNQA LGRNLDANAM RNHFYRFPGV DNDKDKTLSA MLRMAVIAQT QERYEKAPVE
TDEQRAEKAA LEGLVKQLFV ELKRDFKPSD LPPYTLVKLG MHLAGTSQPE ESISYFDEIL
DPSEPDPVRK KARINGMSKY RKNAVFGKAV ALGRSKDNAK VDTAIKMMRD ELSKEESSSN
PDRKAMEDAQ YNLVKFTSAR QDWPAVIAAA DKYRENKTYK KNLPEVLYLQ GEAYLKQNEL
DKALINFMNI TGTYKGLVKW SAPAVLAQMD TLWKRNTMSQ GAGKQPSDRY VAWKAGSQYV
QLLDTPANRK KMTAEDSALV NEVKDKTAKF GSDPAVSQER ADIAAYEAAV RAAKGQK
//
