ID B2URF2_AKKM8 Unreviewed; 699 AA.
AC B2URF2;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=ATP-dependent DNA helicase RecG {ECO:0000256|ARBA:ARBA00017846};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN OrderedLocusNames=Amuc_1212 {ECO:0000313|EMBL:ACD05037.1};
OS Akkermansia muciniphila (strain ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC
OS 81048 / CCUG 64013 / CIP 107961 / Muc).
OC Bacteria; Verrucomicrobiota; Verrucomicrobiae; Verrucomicrobiales;
OC Akkermansiaceae; Akkermansia.
OX NCBI_TaxID=349741 {ECO:0000313|EMBL:ACD05037.1, ECO:0000313|Proteomes:UP000001031};
RN [1] {ECO:0000313|Proteomes:UP000001031}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-835 / DSM 22959 / JCM 33894 / BCRC 81048 / CCUG 64013
RC / CIP 107961 / Muc {ECO:0000313|Proteomes:UP000001031};
RX PubMed=21390229; DOI=10.1371/journal.pone.0016876;
RA van Passel M.W., Kant R., Zoetendal E.G., Plugge C.M., Derrien M.,
RA Malfatti S.A., Chain P.S., Woyke T., Palva A., de Vos W.M., Smidt H.;
RT "The genome of Akkermansia muciniphila, a dedicated intestinal mucin
RT degrader, and its use in exploring intestinal metagenomes.";
RL PLoS ONE 6:E16876-E16876(2011).
CC -!- SIMILARITY: Belongs to the helicase family. RecG subfamily.
CC {ECO:0000256|ARBA:ARBA00007504}.
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DR EMBL; CP001071; ACD05037.1; -; Genomic_DNA.
DR AlphaFoldDB; B2URF2; -.
DR STRING; 349741.Amuc_1212; -.
DR PaxDb; 349741-Amuc_1212; -.
DR KEGG; amu:Amuc_1212; -.
DR eggNOG; COG1200; Bacteria.
DR HOGENOM; CLU_005122_7_1_0; -.
DR BioCyc; AMUC349741:G1GBX-1290-MONOMER; -.
DR Proteomes; UP000001031; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR047112; RecG/Mfd.
DR InterPro; IPR045562; RecG_dom3_C.
DR InterPro; IPR033454; RecG_wedge.
DR PANTHER; PTHR47964; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR PANTHER; PTHR47964:SF1; ATP-DEPENDENT DNA HELICASE HOMOLOG RECG, CHLOROPLASTIC; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF19833; RecG_dom3_C; 1.
DR Pfam; PF17191; RecG_wedge; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:ACD05037.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001031}.
FT DOMAIN 295..451
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 473..630
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 699 AA; 78519 MW; 038BC5DECFF384CC CRC64;
MVHDKGYVLG FMAGELLLTS SLEECVFIRP RELAAMQAAG MASVRDLLFM LPRRYEDRRM
FDRYDSLSSG VPVCLRGRVV DVGWKGWGGR GGKGRGRYVE AVLADEQSLG QTRFSCLWFS
MPGVARMLCA GQEMIVYGRM KPYGKKLSMV HPDFEIIREG DEQSIHLNRI VPVYGGRMGI
AVRRLREIVW ETLSRLSPAP EPEVYEFVPD TPCKTALRDL HFPETAEARD RARRRFALEE
CLAQQLNVAY RRRRADEVPG MRTAGSSHLV KDLADSLPFE LTEAQKRCVR EIYRDMKAPR
SMNRLLQGDV GSGKTLVALC AMLLAVEHGY SAVMMAPTQI LAEQHYLKFR QMLDKLDVPV
SLVTADRKEE SHVSFGKQGG IVVGTHALLY GKNVPERVGL VVIDEQHKFG VNQREKLIDR
EERPDVLVMT ATPIPRTLTL TFYGELDVSI LDGVPRGRGA VVTAIRTEKD KGKVLAFVRN
QLEEGRQIYV VSPLIDGEDS RKGKAVTKEW DEWKALLPHV DVGLLHGRMS SEEKEAVMKD
FRSNRISVLV STTVVEVGVD VPNATVMIIN NAESFGLSQL HQLRGRIGRG SHKSYCILMT
DARPEDEQWE KLRIVETTAN GFDLAEQDLR LRGPGDVLGT SQSGLKGVRF EEWLLDARLI
HRGRQLAEAI LAEDPNLESA KYRPLRFLLE DGAGRRVAG
//
