ID B2WLU7_PYRTR Unreviewed; 745 AA.
AC B2WLU7;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Terpene cyclase/mutase family member {ECO:0000256|RuleBase:RU362003};
DE EC=5.4.99.- {ECO:0000256|RuleBase:RU362003};
GN ORFNames=PTRG_10957 {ECO:0000313|EMBL:EDU44007.1};
OS Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus)
OS (Drechslera tritici-repentis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC Pyrenophora.
OX NCBI_TaxID=426418 {ECO:0000313|EMBL:EDU44007.1, ECO:0000313|Proteomes:UP000001471};
RN [1] {ECO:0000313|Proteomes:UP000001471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pt-1C-BFP {ECO:0000313|Proteomes:UP000001471};
RX PubMed=23316438; DOI=10.1534/g3.112.004044;
RA Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B.,
RA Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H.,
RA Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W.,
RA Schwartz D.C., Spatafora J.W., Turgeon B.G., Yandava C., Young S., Zhou S.,
RA Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.;
RT "Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-
RT repentis, reveals transduplication and the impact of repeat elements on
RT pathogenicity and population divergence.";
RL G3 (Bethesda) 3:41-63(2013).
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755, ECO:0000256|RuleBase:RU362003}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS231629; EDU44007.1; -; Genomic_DNA.
DR RefSeq; XP_001941288.1; XM_001941253.1.
DR AlphaFoldDB; B2WLU7; -.
DR STRING; 426418.B2WLU7; -.
DR EnsemblFungi; EDU44007; EDU44007; PTRG_10957.
DR GeneID; 6349269; -.
DR eggNOG; KOG0497; Eukaryota.
DR HOGENOM; CLU_009074_2_1_1; -.
DR InParanoid; B2WLU7; -.
DR OMA; CWARQTI; -.
DR OrthoDB; 2712461at2759; -.
DR Proteomes; UP000001471; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR Gene3D; 6.20.120.20; -; 1.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000256|RuleBase:RU362003};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022955};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022955};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001471};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Steroid biosynthesis {ECO:0000256|ARBA:ARBA00022955};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 309..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 126..298
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 406..736
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
SQ SEQUENCE 745 AA; 85535 MW; 44E1BED422628702 CRC64;
MTQVNGTTNG VTKRGASQKI IDDAVGVVKS KEGHEKTDYS RWRLKDDRGC QTWHYLTSDE
EMKAWPQSTA DKYFLGLDTE QPDLKPAKTP LEAAANGLSF FSELQLPPGN WGCEYGGPMF
LLPGLVITWY VTETPIPASH AIEIKNYLFA RAHPEDGGWG LHIEGESTVF GTAMNYTVLR
LLGADAEDPR MVKARKTLWK LGGALNAPHW AKFWLSVMGV THWDVVNPCP PELWLLPDWV
PIAPWRWWIH MRQVFLPMCF IYSRKWSYPL NDLTSQLRAE LLMEPYETIN FDARRNTIAD
TDNYHPKTWF LKFLFWFIVA IWIPYLRPNW MIKRAEEHVW WLIQAEDENT DYANLGPVNG
PMNTLCVYIR DGPNCHAFKE HLKTLPEFLW VKDEGMLMNG TNGVQTWDIA FVAQAVEACG
FSKDEKWTPM LAKVLEFLED QQILEESRDQ HACYRQQRKG AWGFSTRKQS YTVSDCTAEA
LKSILILQNR NNYPSLIPDN RLKLAIDVLL TMQNASGGVA TYEPTRGSEL LEHLNAAEVF
GRIMIEYDYP ECTTAVVTGL HMFQTHFPNY RAQEISAFRD RAVGYIRSSQ RPDGSWYGSW
GICFTYAGMF ALESLKCSGE QYSNSERVRR ACQFFLDRQM EDGGWGETYK SCEQGVWHQH
PRSQVVQTAW VVIALLEGGY PEKEPLRRAV KLIMERQQGN GEWLQEAIEG VFNKSCMISY
PNYKFIFPVK ALGMYAKAFG DDALF
//
