ID B2WN99_PYRTR Unreviewed; 1615 AA.
AC B2WN99;
DT 01-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 01-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Rho guanyl nucleotide exchange factor {ECO:0000313|EMBL:EDU44406.1};
GN ORFNames=PTRG_11356 {ECO:0000313|EMBL:EDU44406.1};
OS Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus)
OS (Drechslera tritici-repentis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Pleosporaceae;
OC Pyrenophora.
OX NCBI_TaxID=426418 {ECO:0000313|EMBL:EDU44406.1, ECO:0000313|Proteomes:UP000001471};
RN [1] {ECO:0000313|Proteomes:UP000001471}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Pt-1C-BFP {ECO:0000313|Proteomes:UP000001471};
RX PubMed=23316438; DOI=10.1534/g3.112.004044;
RA Manning V.A., Pandelova I., Dhillon B., Wilhelm L.J., Goodwin S.B.,
RA Berlin A.M., Figueroa M., Freitag M., Hane J.K., Henrissat B., Holman W.H.,
RA Kodira C.D., Martin J., Oliver R.P., Robbertse B., Schackwitz W.,
RA Schwartz D.C., Spatafora J.W., Turgeon B.G., Yandava C., Young S., Zhou S.,
RA Zeng Q., Grigoriev I.V., Ma L.-J., Ciuffetti L.M.;
RT "Comparative genomics of a plant-pathogenic fungus, Pyrenophora tritici-
RT repentis, reveals transduplication and the impact of repeat elements on
RT pathogenicity and population divergence.";
RL G3 (Bethesda) 3:41-63(2013).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS231631; EDU44406.1; -; Genomic_DNA.
DR RefSeq; XP_001941687.1; XM_001941652.1.
DR STRING; 426418.B2WN99; -.
DR EnsemblFungi; EDU44406; EDU44406; PTRG_11356.
DR GeneID; 6349667; -.
DR eggNOG; KOG4305; Eukaryota.
DR HOGENOM; CLU_001083_2_0_1; -.
DR InParanoid; B2WN99; -.
DR OMA; DMFYHPG; -.
DR OrthoDB; 2734900at2759; -.
DR Proteomes; UP000001471; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041675; PH_5.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR46572:SF1; RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF15405; PH_5; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00036; CNH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001471}.
FT DOMAIN 811..1003
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1039..1215
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1280..1582
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 1..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..279
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 293..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..311
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..546
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1615 AA; 177534 MW; C37615E33BABC7A6 CRC64;
MSYYGNGQNY YNPNIPHSSG GGGPAQYQHR RSISSADQIS HTNGGPPTAY GALMQPERRN
SLAARQNDEL FIGANSSPQP SQGPMSPTSA GGYSSGYGYN PQDYNTQPIT MPNPQQFGAN
RTFAPPVSVS SHQPYNPAVY ASNSLVRTNT ANHPYGFSPT SPTVPFPSPA SYQSSQFARA
PSVQSRTSAY ATPASNASSG YYASNASHAP LPSPPTYDTG YGSQRGERYS GHSNQLPPTP
EVPPHGSPQR SSTVSSRPLP PPPPNEDDDD DYFSPTNDYQ DELFNDVLSM TSTSASGAQV
QPPNGQYYEE NGHNGGQMVP YPPGRETYAS DESDVEAAAG LAALQMAEEQ DRADEARRAS
GGGPGLYSNY SSVHSPPMPV EPVQGGSASD SDYVGMDVGT YGGGFMPSFN YGGDPDQLAA
GGHTASSSGS QRRSDHPGDD YDPIHPFPSF ASNARVDTFG TGGLEEPSAR RRSYDEGDEV
ILMDNASGIS GSTLVGPSAV MPGEPPDMFY HPGISNRPLP PPPVNTSPRR LNHQSNGSSG
SGSYEYWRNA PSARGSYPTD PNALQMISPT GAYVPRSTSL LQHSNARDAI PLPRSKTDAE
QGHRPRGAGN RNTFYGGAMD SDGNTLTPGS AEAVAIDLPT IPAGKRFNPA KLSSIDFKRC
TEPWALSSII SWLKSMTEGE NDLKEAPIQE GLIALFTHKV PTMNIADAET LSSRVVADMY
KAGTLVHEEE WLKFSTASMT GVIFQLTGAG CYAPMLHTHA SPGRCYSHHC QRTLKKIDLH
APSAAPRAED WATFYKLKKE DLEGANKKEI ERQNILHEIV QGEDNYMNRL DVLRHLYRDR
LQSAQPPVIP PKKLDKFIRD VFSKVDAVRK ANEDHLLPQI KYRQQEQGPW IVGFSDIFRE
WIRKAKQAYI EYAAAFPYAS FLVRQEADRN MLFRTFLDEA QKNKLSNKLG WDTYLKGPID
RLQRYGLLID TVIKYSTVDN EEKRNLQIAK EEIKAVTLEC DSRVAEMSRK VNLTDLQNKL
ILRPGMQRVE LNLDHLGREL IFRGDLQRMG ANRFNWLETH ALLFDHYLVL AKTVAHREAD
GFTKSDKYDV SKLPIPMDLL VLESEDDDPV VRSTMKGIST VTTVSGRVGG GAAARINSPL
PGALQYTNTS NSLGSQTTNG SGKTLVNTAS NDVAKDEKVL YPFRVKHLGK ETYTLYAPSA
QNRAEWCDNL IIAKTRHAAA LFAQNAEPFR LRVMADAAFA YDSAMPSQRA ITIKGTPLDR
AVDEVEKLFI NVGRPAPICR ARVNCATAFN QPYGKHMVAV GTDIGVFVSD FDNPRGWQKA
IQIPRVTQIA VLEQFSLMLL ISDKSLIAYH LDAVCPVSGV APSSDSTRRA PQKLSGARDI
GFFATGVMKD RTLVFYKKRD NISSTFKVLE PVYQKSTEKK SRIWKTGRTE FFREYDEFYI
PAECYTINLF HSSLAISTAK GFEVLTLDKK HPWSVPDLEQ PHVATIASRL QNQNPLGMFR
LSDQEFLLCY EECAVYINKN GDISRSVIME FVGKAKSAAM YGPYVLLFDP DFVEIRNAQN
GRLRQVIAGR DVKCLDDGLS GGSAHNRTVK LSLQHPAHER SQVVVELVLN EGQKE
//
