ID B3DGJ7_DANRE Unreviewed; 138 AA.
AC B3DGJ7; A0A2R8Q8G5; B3DGK7;
DT 22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE SubName: Full=Chemokine (C-C motif) ligand 34a, duplicate 4 {ECO:0000313|Ensembl:ENSDARP00000149475};
DE SubName: Full=Si:ch211-122l24.4 protein {ECO:0000313|EMBL:AAI62431.1};
GN Name=ccl34a.4 {ECO:0000313|Ensembl:ENSDARP00000149475,
GN ECO:0000313|RefSeq:NP_001124127.1,
GN ECO:0000313|ZFIN:ZDB-GENE-070912-32};
GN Synonyms=si:ch211-122l24.4 {ECO:0000313|EMBL:AAI62421.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI62431.1};
RN [1] {ECO:0000313|RefSeq:NP_001124127.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16365434;
RA DeVries M.E., Kelvin A.A., Xu L., Ran L., Robinson J., Kelvin D.J.;
RT "Defining the origins and evolution of the chemokine/chemokine receptor
RT system.";
RL J. Immunol. 176:401-415(2006).
RN [2] {ECO:0000313|RefSeq:NP_001124127.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=18482437; DOI=10.1186/1471-2164-9-222;
RA Nomiyama H., Hieshima K., Osada N., Kato-Unoki Y., Otsuka-Ono K.,
RA Takegawa S., Izawa T., Yoshizawa A., Kikuchi Y., Tanase S., Miura R.,
RA Kusuda J., Nakao M., Yoshie O.;
RT "Extensive expansion and diversification of the chemokine gene family in
RT zebrafish: identification of a novel chemokine subfamily CX.";
RL BMC Genomics 9:222-222(2008).
RN [3] {ECO:0000313|EMBL:AAI62431.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|RefSeq:NP_001124127.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=20153439;
RA Jin Y., Chen R., Liu W., Fu Z.;
RT "Effect of endocrine disrupting chemicals on the transcription of genes
RT related to the innate immune system in the early developmental stage of
RT zebrafish (Danio rerio).";
RL Fish Shellfish Immunol. 28:854-861(2010).
RN [5] {ECO:0000313|RefSeq:NP_001124127.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21316461;
RA Jin Y., Zheng S., Fu Z.;
RT "Embryonic exposure to cypermethrin induces apoptosis and immunotoxicity in
RT zebrafish (Danio rerio).";
RL Fish Shellfish Immunol. 30:1049-1054(2011).
RN [6] {ECO:0000313|RefSeq:NP_001124127.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23145839;
RA Nomiyama H., Osada N., Yoshie O.;
RT "Systematic classification of vertebrate chemokines based on conserved
RT synteny and evolutionary history.";
RL Genes Cells 18:1-16(2013).
RN [7] {ECO:0000313|Ensembl:ENSDARP00000149475, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000149475};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [8] {ECO:0000313|RefSeq:NP_001124127.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29859490;
RA Li H., Cao F., Zhao F., Yang Y., Teng M., Wang C., Qiu L.;
RT "Developmental toxicity, oxidative stress and immunotoxicity induced by
RT three strobilurins (pyraclostrobin, trifloxystrobin and picoxystrobin) in
RT zebrafish embryos.";
RL Chemosphere 207:781-790(2018).
RN [9] {ECO:0000313|RefSeq:NP_001124127.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29480392;
RA Xu C., Li X., Jin M., Sun X., Niu L., Lin C., Liu W.;
RT "Early life exposure of zebrafish (Danio rerio) to synthetic pyrethroids
RT and their metabolites: a comparison of phenotypic and behavioral indicators
RT and gene expression involved in the HPT axis and innate immune system.";
RL Environ. Sci. Pollut. Res. Int. 25:12992-13003(2018).
RN [10] {ECO:0000313|RefSeq:NP_001124127.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29510255;
RA Nikapitiya C., Dananjaya S.H.S., De Silva B.C.J., Heo G.J., Oh C.,
RA De Zoysa M., Lee J.;
RT "Chitosan nanoparticles: A positive immune response modulator as display in
RT zebrafish larvae against Aeromonas hydrophila infection.";
RL Fish Shellfish Immunol. 76:240-246(2018).
RN [11] {ECO:0000313|RefSeq:NP_001124127.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29964197;
RA Chandrarathna H.P.S.U., Nikapitiya C., Dananjaya S.H.S., Wijerathne C.U.B.,
RA Wimalasena S.H.M.P., Kwun H.J., Heo G.J., Lee J., De Zoysa M.;
RT "Outcome of co-infection with opportunistic and multidrug resistant
RT Aeromonas hydrophila and A. veronii in zebrafish: Identification,
RT characterization, pathogenicity and immune responses.";
RL Fish Shellfish Immunol. 80:573-581(2018).
RN [12] {ECO:0000313|RefSeq:NP_001124127.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=29572872;
RA Zhang Q., Ji C., Ren J., Zhang Q., Dong X., Zu Y., Jia L., Li W.;
RT "Differential transcriptome analysis of zebrafish (Danio rerio) larvae
RT challenged by Vibrio parahaemolyticus.";
RL J. Fish Dis. 41:1049-1062(2018).
RN [13] {ECO:0000313|Ensembl:ENSDARP00000149475}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000149475};
RG Ensembl;
RL Submitted (APR-2018) to UniProtKB.
RN [14] {ECO:0000313|RefSeq:NP_001124127.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; FP236331; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC162421; AAI62421.1; -; mRNA.
DR EMBL; BC162431; AAI62431.1; -; mRNA.
DR RefSeq; NP_001124127.1; NM_001130655.1.
DR STRING; 7955.ENSDARP00000149475; -.
DR PaxDb; 7955-ENSDARP00000109898; -.
DR Ensembl; ENSDART00000113901; ENSDARP00000149475; ENSDARG00000090873.
DR Ensembl; ENSDART00000113901.4; ENSDARP00000149475.1; ENSDARG00000090873.4.
DR GeneID; 100170820; -.
DR KEGG; dre:100170820; -.
DR AGR; ZFIN:ZDB-GENE-070912-32; -.
DR CTD; 100170820; -.
DR ZFIN; ZDB-GENE-070912-32; ccl34a.4.
DR OMA; CCTISTK; -.
DR OrthoDB; 4262818at2759; -.
DR Reactome; R-DRE-380108; Chemokine receptors bind chemokines.
DR Reactome; R-DRE-418594; G alpha (i) signalling events.
DR Proteomes; UP000000437; Chromosome 2.
DR Bgee; ENSDARG00000090873; Expressed in spleen and 17 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0048020; F:CCR chemokine receptor binding; IBA:GO_Central.
DR GO; GO:0008009; F:chemokine activity; IBA:GO_Central.
DR GO; GO:0071347; P:cellular response to interleukin-1; IBA:GO_Central.
DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IBA:GO_Central.
DR GO; GO:0071346; P:cellular response to type II interferon; IBA:GO_Central.
DR GO; GO:0070098; P:chemokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0042742; P:defense response to bacterium; IDA:ZFIN.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IDA:ZFIN.
DR GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR GO; GO:0048247; P:lymphocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0002548; P:monocyte chemotaxis; IBA:GO_Central.
DR GO; GO:0030593; P:neutrophil chemotaxis; IBA:GO_Central.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR CDD; cd00272; Chemokine_CC; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR001811; Chemokine_IL8-like_dom.
DR InterPro; IPR036048; Interleukin_8-like_sf.
DR Pfam; PF00048; IL8; 1.
DR SMART; SM00199; SCY; 1.
DR SUPFAM; SSF54117; Interleukin 8-like chemokines; 1.
PE 2: Evidence at transcript level;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001124127.1}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..138
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001124127.1"
FT /id="PRO_5035035099"
FT DOMAIN 31..88
FT /note="Chemokine interleukin-8-like"
FT /evidence="ECO:0000259|SMART:SM00199"
SQ SEQUENCE 138 AA; 15557 MW; 0155C77A42BB53DE CRC64;
MQLNQKMMMR LAAIAVIMSV MIMKTNGQNR FVQCCTSVST KEITLPITGF KYQKRNPPCV
KAVIFFTKEG EQCIHWNQSW VREKIQELII SMEKMNSTVS TPLKMNSTLS TLLRINSTIS
TALQMNSTLS TPLSTSSS
//
