ID B3DI79_DANRE Unreviewed; 190 AA.
AC B3DI79; B3DI92; F6NWX6;
DT 22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE SubName: Full=LOC555483 protein {ECO:0000313|EMBL:AAI63043.1};
DE SubName: Full=Prostaglandin D2 synthase a {ECO:0000313|Ensembl:ENSDARP00000091851, ECO:0000313|RefSeq:NP_001186920.1};
GN Name=ptgdsa {ECO:0000313|Ensembl:ENSDARP00000091851,
GN ECO:0000313|RefSeq:NP_001186920.1,
GN ECO:0000313|ZFIN:ZDB-GENE-081022-118};
GN Synonyms=im:7160217 {ECO:0000313|RefSeq:NP_001186920.1}, LOC555483
GN {ECO:0000313|EMBL:AAI63043.1}, zgc:194505
GN {ECO:0000313|RefSeq:NP_001186920.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:AAI63043.1};
RN [1] {ECO:0000313|RefSeq:NP_001186920.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=16616995; DOI=10.1016/j.gene.2006.01.037;
RA Fujimori K., Inui T., Uodome N., Kadoyama K., Aritake K., Urade Y.;
RT "Zebrafish and chicken lipocalin-type prostaglandin D synthase homologues:
RT Conservation of mammalian gene structure and binding ability for lipophilic
RT molecules, and difference in expression profile and enzyme activity.";
RL Gene 375:14-25(2006).
RN [2] {ECO:0000313|EMBL:AAI63043.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSDARP00000091851}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000091851};
RG Ensembl;
RL Submitted (FEB-2012) to UniProtKB.
RN [4] {ECO:0000313|Ensembl:ENSDARP00000091851, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000091851};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001186920.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [6] {ECO:0000313|RefSeq:NP_001186920.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000256|ARBA:ARBA00006889, ECO:0000256|RuleBase:RU003695}.
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DR EMBL; BX005370; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC163029; AAI63029.1; -; mRNA.
DR EMBL; BC163043; AAI63043.1; -; mRNA.
DR RefSeq; NP_001186920.1; NM_001199991.1.
DR STRING; 7955.ENSDARP00000091851; -.
DR PaxDb; 7955-ENSDARP00000091851; -.
DR Ensembl; ENSDART00000101077; ENSDARP00000091851; ENSDARG00000069439.
DR Ensembl; ENSDART00000101077.5; ENSDARP00000091851.3; ENSDARG00000069439.5.
DR GeneID; 555483; -.
DR KEGG; dre:555483; -.
DR AGR; ZFIN:ZDB-GENE-081022-118; -.
DR CTD; 555483; -.
DR ZFIN; ZDB-GENE-081022-118; ptgdsa.
DR eggNOG; ENOG502RYFQ; Eukaryota.
DR OMA; TLAHANV; -.
DR OrthoDB; 3932172at2759; -.
DR TreeFam; TF336103; -.
DR Proteomes; UP000000437; Alternate scaffold 10.
DR Proteomes; UP000000437; Chromosome 10.
DR Bgee; ENSDARG00000069439; Expressed in liver and 12 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR CDD; cd19419; lipocalin_L-PGDS; 1.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR002345; Lipocalin.
DR InterPro; IPR022272; Lipocalin_CS.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR PANTHER; PTHR11430; LIPOCALIN; 1.
DR PANTHER; PTHR11430:SF63; LOC555483 PROTEIN-RELATED; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PRINTS; PR00179; LIPOCALIN.
DR PRINTS; PR01254; PGNDSYNTHASE.
DR SUPFAM; SSF50814; Lipocalins; 1.
DR PROSITE; PS00213; LIPOCALIN; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001186920.1}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..190
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001186920.1"
FT /id="PRO_5035035278"
FT DOMAIN 30..169
FT /note="Lipocalin/cytosolic fatty-acid binding"
FT /evidence="ECO:0000259|Pfam:PF00061"
SQ SEQUENCE 190 AA; 21805 MW; C3CAC884F90B1702 CRC64;
MKVTIFLLMI LKEVHANVQP QKNFDLQRFA GRWYRIGLAY DSPGFVPHRS KVTISMGTVE
PQDNGNVNMT MWSLTSSGCK QKIYIYEKTS VSGVFNYYST RHRRMKDVTV VETNYSEYAM
VVKHKKMNKE YTQVSLYGRA KKLKADLMEK FRAYATALGF SKESILTPPT ARNCPPKEAS
QSFIQVKAGY
//
