ID B3DLI2_XENTR Unreviewed; 679 AA.
AC B3DLI2;
DT 22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=LOC100170494 protein {ECO:0000313|EMBL:AAI67457.1};
DE SubName: Full=Rho guanine nucleotide exchange factor 25 {ECO:0000313|Ensembl:ENSXETP00000076994, ECO:0000313|RefSeq:NP_001123746.1};
GN Name=arhgef25 {ECO:0000313|Ensembl:ENSXETP00000076994,
GN ECO:0000313|RefSeq:NP_001123746.1,
GN ECO:0000313|Xenbase:XB-GENE-6084380};
GN Synonyms=geft {ECO:0000313|RefSeq:NP_001123746.1}, LOC100170494
GN {ECO:0000313|EMBL:AAI67457.1}, p63rhogef
GN {ECO:0000313|RefSeq:NP_001123746.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI67457.1};
RN [1] {ECO:0000313|RefSeq:NP_001123746.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAI67457.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000313|EMBL:AAI67457.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000076994}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000076994};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [4] {ECO:0000313|Ensembl:ENSXETP00000076994}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (MAY-2020) to UniProtKB.
RN [5] {ECO:0000313|RefSeq:NP_001123746.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BC167457; AAI67457.1; -; mRNA.
DR RefSeq; NP_001123746.1; NM_001130274.1.
DR PaxDb; 8364-ENSXETP00000013674; -.
DR Ensembl; ENSXETT00000099134; ENSXETP00000076994; ENSXETG00000036584.
DR GeneID; 100170494; -.
DR KEGG; xtr:100170494; -.
DR AGR; Xenbase:XB-GENE-6084380; -.
DR CTD; 115557; -.
DR Xenbase; XB-GENE-6084380; arhgef25.
DR eggNOG; KOG0689; Eukaryota.
DR eggNOG; KOG4240; Eukaryota.
DR HOGENOM; CLU_001356_6_1_1; -.
DR OrthoDB; 2906033at2759; -.
DR TreeFam; TF318080; -.
DR Proteomes; UP000008143; Chromosome 2.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13241; PH2_Kalirin_Trio_p63RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22826:SF117; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY G MEMBER 4B-RELATED; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16609; SH3-RhoG_link; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 209..385
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 397..512
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 47..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 163..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 529..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..592
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 622..645
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 679 AA; 77213 MW; 3DF2C165F346CA43 CRC64;
MRGGNPRHGC ACQNLFRKVL SQCSCCYARV RESYSIAGSD GSISASVASI QPQPSTSSAP
SSPGSRRSVS TLKKWLTNPV RKLSSGSRLD QRQSKKIESR PKRGVPGRRR SADDGGRRSF
DLGVLRKMDE FTHPEDKGSE WKEQDHPERL PDLSILNDLL QGVTTEPNNK DPHTSYLSDP
TDSLASELPV TPSFPPAETE EEKKSALEKS MYVLMELIET EKMYVEDLRQ IVEGYMATMN
TQGIPEDMKG KDKIVFGNIH QIFDWHKDYF LSELQKCLED PNRLAILFIK HERRLHMYVV
YCQNKPKSEH IVSEYIDTYF EELRQQLSHR LQLNDLLIKP VQRIMKYQLL LKDFLKYYSK
AGQDTSELEK AVEVMCFVPK RCNDMMNLGR LQGFEGKITA QGKLLQQDTF LVNEQESSFL
TRCKERRVFL FEQIIIFSEP IDKKKDFSLP GYIFKNSIKI SCLGIEESID NDPCKFVLTS
RGADRSLVRY ILQASTQEIR LAWIKDIGQI LESQRNFLNA LQSPIEYQRR ESKSNSLGRN
SNLRIMETSR GGLRPHSSSS MDRNKVPNLK SYNSSLPSLY LPSNPRQDSR QFGNKVHSAR
KSSHSDALPS PAILSPTHIS LDFHHPESSS PTVSNGTPQS DSTSRKPSLS ERELPGYASS
PEDYGVPTPR LAKLDEDEL
//
