ID B3EKV4_CHLPB Unreviewed; 432 AA.
AC B3EKV4;
DT 22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Homoaconitate hydratase family protein {ECO:0000313|EMBL:ACE04640.1};
DE EC=4.2.1.33 {ECO:0000313|EMBL:ACE04640.1};
GN OrderedLocusNames=Cphamn1_1722 {ECO:0000313|EMBL:ACE04640.1};
OS Chlorobium phaeobacteroides (strain BS1).
OC Bacteria; Chlorobiota; Chlorobiia; Chlorobiales; Chlorobiaceae;
OC Chlorobium/Pelodictyon group; Chlorobium.
OX NCBI_TaxID=331678 {ECO:0000313|EMBL:ACE04640.1};
RN [1] {ECO:0000313|EMBL:ACE04640.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BS1 {ECO:0000313|EMBL:ACE04640.1};
RG US DOE Joint Genome Institute;
RA Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Schmutz J., Larimer F., Land M.,
RA Hauser L., Kyrpides N., Ovchinnikova G., Li T., Liu Z., Zhao F.,
RA Overmann J., Bryant D.A., Richardson P.;
RT "Complete sequence of Chlorobium phaeobacteroides BS1.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP001101; ACE04640.1; -; Genomic_DNA.
DR AlphaFoldDB; B3EKV4; -.
DR STRING; 331678.Cphamn1_1722; -.
DR KEGG; cpb:Cphamn1_1722; -.
DR eggNOG; COG0065; Bacteria.
DR HOGENOM; CLU_006714_3_4_10; -.
DR OrthoDB; 9764318at2; -.
DR GO; GO:0003861; F:3-isopropylmalate dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:InterPro.
DR CDD; cd01583; IPMI; 1.
DR Gene3D; 3.30.499.10; Aconitase, domain 3; 2.
DR InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR InterPro; IPR018136; Aconitase_4Fe-4S_BS.
DR InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR InterPro; IPR006251; Homoacnase/IPMdehydase_lsu.
DR InterPro; IPR033941; IPMI_cat.
DR NCBIfam; TIGR01343; hacA_fam; 1.
DR PANTHER; PTHR43822:SF2; 3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT, CHLOROPLASTIC; 1.
DR PANTHER; PTHR43822; HOMOACONITASE, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF00330; Aconitase; 2.
DR PRINTS; PR00415; ACONITASE.
DR SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR PROSITE; PS01244; ACONITASE_2; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:ACE04640.1};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}.
FT DOMAIN 8..291
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
FT DOMAIN 292..422
FT /note="Aconitase/3-isopropylmalate dehydratase large
FT subunit alpha/beta/alpha"
FT /evidence="ECO:0000259|Pfam:PF00330"
SQ SEQUENCE 432 AA; 47030 MW; FB6CDEE80A533D76 CRC64;
MTQTITQKIL ARAANRKFVE AGENIWLNVD VLLTHDVCGP PTFDIFREKF GPEAKVWDPE
KIVVLPDHYI FTENEHAHRN IDLLREFANE QKLPNYYDVG TKRYKGVCHV ALAQEGYNLP
GTVLFGTDSH TCTSGAFGMF GTGIGNTDAA FILGTGKIWE KVPESMKFIF EGEMPEYLMA
KDLILQILGD ISTDGATYRA MEFDGSAVFS LPMEERMTLT NMAIEAGGMS GIIAADSITE
AYVKERSDKP YEIFTSDPDA LYHSIHRYKT EELEPVVAMP HSPDNRATVR SVQGTKITKS
YIGSCTGGKL IDFVMAAKVL KGNTVSVPTN IVPATVEVAQ SLTTEEFDGQ PIITILKEAG
CTIAPPSCAA CLGGPSDTFG RSVDNDLVVS TTNRNFPGRM GSKKAGVCLA SPLTAAASAI
TGKLTDPREF LR
//
