ID B3ERW2_AMOA5 Unreviewed; 1121 AA.
AC B3ERW2;
DT 22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=HD domain-containing protein {ECO:0000259|PROSITE:PS51831};
GN OrderedLocusNames=Aasi_0563 {ECO:0000313|EMBL:ACE05964.1};
OS Amoebophilus asiaticus (strain 5a2).
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Amoebophilaceae;
OC Candidatus Amoebophilus.
OX NCBI_TaxID=452471 {ECO:0000313|EMBL:ACE05964.1, ECO:0000313|Proteomes:UP000001227};
RN [1] {ECO:0000313|EMBL:ACE05964.1, ECO:0000313|Proteomes:UP000001227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=5a2 {ECO:0000313|EMBL:ACE05964.1,
RC ECO:0000313|Proteomes:UP000001227};
RX PubMed=20023027; DOI=10.1128/JB.01379-09;
RA Schmitz-Esser S., Tischler P., Arnold R., Montanaro J., Wagner M.,
RA Rattei T., Horn M.;
RT "The genome of the amoeba symbiont 'Candidatus Amoebophilus asiaticus'
RT reveals common mechanisms for host cell interaction among amoeba-associated
RT bacteria.";
RL J. Bacteriol. 192:1045-1057(2010).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21)
CC family. {ECO:0000256|ARBA:ARBA00006434}.
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DR EMBL; CP001102; ACE05964.1; -; Genomic_DNA.
DR AlphaFoldDB; B3ERW2; -.
DR STRING; 452471.Aasi_0563; -.
DR TCDB; 3.A.23.6.1; the type vi symbiosis/virulence secretory system (t6ss) family.
DR KEGG; aas:Aasi_0563; -.
DR eggNOG; COG0317; Bacteria.
DR eggNOG; COG0591; Bacteria.
DR HOGENOM; CLU_009319_0_0_10; -.
DR Proteomes; UP000001227; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd00077; HDc; 1.
DR CDD; cd10322; SLC5sbd; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR Gene3D; 1.20.1730.10; Sodium/glucose cotransporter; 1.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR038377; Na/Glc_symporter_sf.
DR InterPro; IPR001734; Na/solute_symporter.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF00474; SSF; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS50283; NA_SOLUT_SYMP_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001227};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..139
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 187..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 269..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 360..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..408
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..530
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 542..562
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 574..593
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 605..637
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 657..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 975..1071
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
SQ SEQUENCE 1121 AA; 125736 MW; 65F877FD53D997E5 CRC64;
MDLMLKDYLD IILFTTFLLV NLIIGLIAGR RVRSLRDFSI GNKDFTTATV TSTIVATWFG
GGFIFYGLQN AYTSGLQYII PLLGSSLCLL FTGQVLAVRM GEFLNNLSVA EAMGNLFSRL
VRIITAISGI LGGIGYIAIQ FQVIAKMLNF LLGFEGPWVT VAAASIVIIY SAFGGIRSVI
ITDLLQFIVF SIFIPILALV VWNHLKKPGQ VAHTLVTNPV FNFKEMLGWN PKFLSALGLV
LYFAIPGITP AIFQRVTISK DLRQVKDSFT YAAASSLLMV ASLAWIAILL LSDNPNLESG
SLVNYIITTY AYPGLKGLIA IGITAMAMST ADSYLNSSAV LAVNDILKPL QLYWKDSIKI
VRVFSFVLGI FALLLALRST DLLQLMLLSG SFYMPIVTVP LLLAIFGFRS SSRSVLIGMS
AGCITVILWN KFLTHTGMQS LIPGMIANLV FYVGSHYILR QQGGWIGIRD REPLLAARQG
RREAWQKFIY KVRHPQIYTY LQKNLPAYEV VYTLFAIYVI GATYASFYTI PESTVANYQK
LYDIAAHSVL VMTAGFLTYP AWPPTFKAKW FITFAWPAGI LYVLFIVGTI LVLMSGFHEV
QVMIFLINLI MTAFLLSWPL MLFVSLVGII IGCLVFYMYC GDLYACTSST GSGQFKVIYG
ILLFSSFLIA LFRFKQSQTR LENKNVYLEN IYKQLKDELS EILGYKETLV KELKEDELAL
FGTTAAAYMQ QAIYRITDYV RLEVSQIKLE DLIVEIKDIL KLKDFDGQSP QLSSKKYTKE
ESIYADADKI KQVLADSICY IHKHNLSNKT IVIALEDAML GHSVEHMKDY TRKLKAIKIT
ITTQELLSNT SNRVYMFDQA PSISRMAGDG DRKALLNNAR IIDAHYGYAE LDKEDTHIYV
LPINVREVRG KVMELLRAPA VASEEEVKHP LAIQLEEELL NKTKTAKLDT NVIEKSLNTI
KRYHAGVKRK SGEPFFTHPI AVALILLDYC KDQDAVIAAL LHDTVEDTSL SITHIKAMFG
EKVAFIVGKV TNLEDKIRRL SLEEHENIKR LINYEDERAA FVKLADRLHN MRTIEGHLSL
SKQKHIANET LLFFVPLANQ LGVDHVAQEL EKLSLEVLAK K
//
