ID B3GWC3_CAEEL Unreviewed; 677 AA.
AC B3GWC3;
DT 22-JUL-2008, integrated into UniProtKB/TrEMBL.
DT 22-JUL-2008, sequence version 1.
DT 27-MAR-2024, entry version 97.
DE RecName: Full=poly(A)-specific ribonuclease {ECO:0000256|ARBA:ARBA00012161};
DE EC=3.1.13.4 {ECO:0000256|ARBA:ARBA00012161};
GN Name=ccr-4 {ECO:0000313|EMBL:CAQ58128.1,
GN ECO:0000313|WormBase:ZC518.3d};
GN ORFNames=CELE_ZC518.3 {ECO:0000313|EMBL:CAQ58128.1}, ZC518.3
GN {ECO:0000313|WormBase:ZC518.3d};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAQ58128.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAQ58128.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAQ58128.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
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DR EMBL; BX284604; CAQ58128.1; -; Genomic_DNA.
DR RefSeq; NP_001129877.1; NM_001136405.1.
DR AlphaFoldDB; B3GWC3; -.
DR SMR; B3GWC3; -.
DR STRING; 6239.ZC518.3d.1; -.
DR PaxDb; 6239-ZC518-3d; -.
DR PeptideAtlas; B3GWC3; -.
DR EnsemblMetazoa; ZC518.3d.1; ZC518.3d.1; WBGene00000376.
DR GeneID; 178184; -.
DR AGR; WB:WBGene00000376; -.
DR WormBase; ZC518.3d; CE42682; WBGene00000376; ccr-4.
DR eggNOG; KOG0620; Eukaryota.
DR HOGENOM; CLU_395501_0_0_1; -.
DR InParanoid; B3GWC3; -.
DR OrthoDB; 37764at2759; -.
DR PhylomeDB; B3GWC3; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00000376; Expressed in embryo and 4 other cell types or tissues.
DR ExpressionAtlas; B3GWC3; baseline and differential.
DR GO; GO:0030014; C:CCR4-NOT complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IBA:GO_Central.
DR CDD; cd09097; Deadenylase_CCR4; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR PANTHER; PTHR12121; CARBON CATABOLITE REPRESSOR PROTEIN 4; 1.
DR PANTHER; PTHR12121:SF34; POLY(A)-SPECIFIC RIBONUCLEASE; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
PE 1: Evidence at protein level;
KW Endonuclease {ECO:0000313|EMBL:CAQ58128.1};
KW Hydrolase {ECO:0000313|EMBL:CAQ58128.1};
KW Nuclease {ECO:0000313|EMBL:CAQ58128.1};
KW Proteomics identification {ECO:0007829|EPD:B3GWC3,
KW ECO:0007829|PeptideAtlas:B3GWC3};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT DOMAIN 296..630
FT /note="Endonuclease/exonuclease/phosphatase"
FT /evidence="ECO:0000259|Pfam:PF03372"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 677 AA; 77076 MW; 2F04A84B9D03CB28 CRC64;
MADSGDGESP SRRNSSGKRF VRRARRWAEL LQKRQGRRNC EESENLSAPI DANFQQAHKH
TAFNNPSSHN RNGIKDQKYR PPEPPHVYDY VEMAALGSGV MVVDDDLNYE FLTHDESRQK
QHLGHTRSFP ITILQSRKHE ISSGLSPAYG YNTHQTCQRT ISDAYHYQAY HQPSYSNHHT
SWYEYQQPSN ASFMKPVDSA LTLITNDLSM ASISEASTTS PSSISNNSEE DVSPHFLKMS
SSFPKSSSFP YRTMSESQCF PFNFHVNTHP PPERNWVMIR HADPERPIAT FTVLCYNVLC
DKYATVNQYS YCPSWALNWE YRKGLIIKEI RTYEADVITL QEVETEQFRT LFQPELKQLG
YAGIFEAKSR AKTMGEEERK YVDGCAIFWK VDKFDMDKQY LFEFSSVAMK KASTSENMLN
RVMPRDNIGL CAVLKIKESV YANKFLGRMQ IPMNDNVVGN PLVVATAHIH WDPEFCDVKL
VQSMMLTHEV SRVLEEVSKK YQITQQQVPV LICGDFNSLP DSGVFEYLSK GQITRRHMDL
KSFRDDSCLE KFTNSTDKNV ISHPLRLDSA CDINSIPFTN YTLDFKGMID YIFATPQSLA
RLGILGPFDP QWVQSNKILG FPHPHVASDH IPIMAQYAII PTTHQRQQPL QQAGPAAGVI
GGGFPSTPSG AQPFLRC
//
