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Database: UniProt
Entry: B3LW19_DROAN
LinkDB: B3LW19_DROAN
Original site: B3LW19_DROAN 
ID   B3LW19_DROAN            Unreviewed;      1588 AA.
AC   B3LW19;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 2.
DT   05-JUN-2019, entry version 77.
DE   SubName: Full=Uncharacterized protein, isoform A {ECO:0000313|EMBL:EDV41552.2};
DE            EC=3.4.24.- {ECO:0000313|EMBL:EDV41552.2};
GN   Name=Dana\GF17538 {ECO:0000313|EMBL:EDV41552.2};
GN   ORFNames=Dana_GF17538 {ECO:0000313|EMBL:EDV41552.2}, GF17538
GN   {ECO:0000313|FlyBase:FBgn0094556};
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217 {ECO:0000313|EMBL:EDV41552.2, ECO:0000313|Proteomes:UP000007801};
RN   [1] {ECO:0000313|EMBL:EDV41552.2, ECO:0000313|Proteomes:UP000007801}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR   EMBL; CH902617; EDV41552.2; -; Genomic_DNA.
DR   RefSeq; XP_001952969.2; XM_001952934.2.
DR   SMR; B3LW19; -.
DR   EnsemblMetazoa; FBtr0122238; FBpp0120730; FBgn0094556.
DR   GeneID; 6500322; -.
DR   KEGG; dan:Dana_GF17538; -.
DR   FlyBase; FBgn0094556; Dana\GF17538.
DR   eggNOG; KOG3607; Eukaryota.
DR   eggNOG; ENOG410XX2M; LUCA.
DR   InParanoid; B3LW19; -.
DR   OrthoDB; 162519at2759; -.
DR   Proteomes; UP000007801; Unassembled WGS sequence.
DR   Bgee; FBgn0094556; Expressed in 1 organ(s), highest expression level in adult organism.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR   CDD; cd04269; ZnMc_adamalysin_II_like; 1.
DR   Gene3D; 3.40.390.10; -; 1.
DR   Gene3D; 4.10.70.10; -; 1.
DR   InterPro; IPR006586; ADAM_Cys-rich.
DR   InterPro; IPR001762; Disintegrin_dom.
DR   InterPro; IPR036436; Disintegrin_dom_sf.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR024079; MetalloPept_cat_dom_sf.
DR   InterPro; IPR001590; Peptidase_M12B.
DR   InterPro; IPR002870; Peptidase_M12B_N.
DR   InterPro; IPR034027; Reprolysin_adamalysin.
DR   Pfam; PF08516; ADAM_CR; 1.
DR   Pfam; PF00200; Disintegrin; 1.
DR   Pfam; PF01562; Pep_M12B_propep; 1.
DR   Pfam; PF01421; Reprolysin; 1.
DR   SMART; SM00608; ACR; 1.
DR   SMART; SM00050; DISIN; 1.
DR   SUPFAM; SSF57552; SSF57552; 1.
DR   PROSITE; PS50215; ADAM_MEPRO; 1.
DR   PROSITE; PS50214; DISINTEGRIN_2; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007801};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00068,
KW   ECO:0000256|SAAS:SAAS00117091};
KW   EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW   Hydrolase {ECO:0000313|EMBL:EDV41552.2};
KW   Membrane {ECO:0000256|SAAS:SAAS01078504};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007801};
KW   Transmembrane {ECO:0000256|SAAS:SAAS01078486};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS01078482}.
FT   DOMAIN      301    497       Peptidase M12B. {ECO:0000259|PROSITE:
FT                                PS50215}.
FT   DOMAIN      503    591       Disintegrin. {ECO:0000259|PROSITE:
FT                                PS50214}.
FT   DOMAIN      741    773       EGF-like. {ECO:0000259|PROSITE:PS50026}.
FT   REGION      841    875       Disordered. {ECO:0000256|MobiDB-lite:
FT                                B3LW19}.
FT   REGION      919    956       Disordered. {ECO:0000256|MobiDB-lite:
FT                                B3LW19}.
FT   REGION      991   1036       Disordered. {ECO:0000256|MobiDB-lite:
FT                                B3LW19}.
FT   REGION     1085   1301       Disordered. {ECO:0000256|MobiDB-lite:
FT                                B3LW19}.
FT   REGION     1403   1576       Disordered. {ECO:0000256|MobiDB-lite:
FT                                B3LW19}.
FT   COMPBIAS    841    864       Polar. {ECO:0000256|MobiDB-lite:B3LW19}.
FT   COMPBIAS    991   1033       Polar. {ECO:0000256|MobiDB-lite:B3LW19}.
FT   COMPBIAS   1113   1129       Pro-rich. {ECO:0000256|MobiDB-lite:
FT                                B3LW19}.
FT   COMPBIAS   1133   1157       Polar. {ECO:0000256|MobiDB-lite:B3LW19}.
FT   COMPBIAS   1172   1211       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                B3LW19}.
FT   COMPBIAS   1246   1262       Polar. {ECO:0000256|MobiDB-lite:B3LW19}.
FT   COMPBIAS   1493   1537       Polar. {ECO:0000256|MobiDB-lite:B3LW19}.
FT   DISULFID    563    583       {ECO:0000256|PROSITE-ProRule:PRU00068}.
FT   DISULFID    745    755       {ECO:0000256|PROSITE-ProRule:PRU00076}.
FT   DISULFID    763    772       {ECO:0000256|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   1588 AA;  169909 MW;  27FAC5732AC8DF0F CRC64;
     MSPRIPLPSA KANIPIPNIN CNNRAARTPK MSRRSRSHLH LHLPLVLLLV LQSTCLLPAE
     AAAEGGGGKP RADYFPATHE FSTHSVIRPK VQHGRTKRSL LSTLDATDGL HTPQISLSYI
     HGGQRTIIDL QRNDGLLPEK HFLRYQNSTR AGSRSGHVVR NFTKTEVDLC HYQGHVRGQP
     DSIVALSTCG GVLDGIVFDG RETYFIHPHV ESTGRLQDHH YLLRQADRLP TNATCGYDSH
     TDNLSHGEDA DDNTVRGNPS LPPLHHLDGG EFQHTLLRRR RSTDGSSQLI RGPYNANKYS
     SYVELVIVVD NKVYKHFQES AKKVHQHCKN LANIINALYV PLNIFVALVG VVIWNESNEI
     EFSSDGDVTL RNFLNYRSTK LVVEHPNDNA QLLTKETFAG GVVGKALKGP ICTYEYSGGV
     SMQHSPNTAM VATTMAHEMG HNFGMEHDSP DCHCPDEKCV MAASSTSVVP VSWSSCSIDQ
     LTIAFSRGMN YCLRNKPERL FESPTCGNGF VEPGEQCDCG LPEHCQNSCC NAHTCMLHSN
     ASCATGECCD LATCRPKMAG SACREAENEC DLPEYCTGES EYCPADVFRR DTEPCDGGQA
     YCFHGNCRSH SNQCRILWGS TGENSEHCYD KNMSGDRMGN CGYNRLNKTY MRCEAEHVKC
     GMLHCIHLNE RLEFGMESAA VLSHSYVSHD RKIVACRTAV VDLGLQSTDP GLTPNGAKCG
     EDKMCVNQKC LPVSTVRSTG MGKACPDDCN GNGICNSMGH CHCDVGFGGE SCGKAGSGGS
     PDSGPATDPN GSPGLKRFLC VLFFFVLPVV GICWLLYQCH KNGLFASGKL KDNMYVSTTS
     SISSSASQGS SSPDSSTITS SPPVKRPAPT APLINTLPLP APTVLVTNTA PATITNTHTL
     SRHKSNPDAV HHVHIQPPQV PKSQSYEMPP RKLSTVPASS SYSNYKNIDT EPQITDNSTL
     RRKLDITAPR LHATTNPLAL TEGAQFIQSG PASLKSSGVS KPATTRSTQN GSGPPPGNGL
     LKSTPSSTDD MDSALLKTPA DSAPATAGMF GKFDGFTLRP LNDATTPSGN YSGPNVAFVQ
     PTVQQDAGAP QRAAPPPPAT KTPSSPKPET TWVRPAPALP PPNPGSTARP IISPPKLDSS
     TLTMVPLKGS TDDLSPRSGS VPPPPVPLHS DPKLNMKRDG TIRRLTSFLK KDEKPPLKEK
     TYIDRERLRT LEISAPMPVP TAPQTESSNS DSETTPREEE TQNLVKRAQS MRSPTKKVPL
     QSFGSMRSPP GLPRPKSGQV NNSSGTSRPK SPPPRPPPVV VKKTNSIISA SGYQRPVSTA
     QRSVENTYDD CEFVEREARA SNDDIYSVID EIPPAAQTLK RSDLVANRTS NGSDMGLLNE
     IVNELEKING ESVYSGKPVA VGATAPAADT PKSPQRPAPP KPASSVLEEK AAVAASTYHR
     TAAVNAPVAR VKPTVADKSA PPPSMSSFKP PAGTGGQPVA PVPLHQAKRS SGGSIAGGGN
     NTASRPKSFV KSTSKTLPNG TGATSAPSAT IQKPKPLSAK PSFSGGAAGG IPGKRLNGAA
     APTPPTVKTT TAPKSSIASL AQRFEQNK
//
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