ID B3MH72_DROAN Unreviewed; 1455 AA.
AC B3MH72;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 97.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN Name=Dana\GF11739 {ECO:0000313|EMBL:EDV36849.1};
GN Synonyms=dana_GLEANR_11772 {ECO:0000313|EMBL:EDV36849.1};
GN ORFNames=GF11739 {ECO:0000313|EMBL:EDV36849.1};
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217 {ECO:0000313|EMBL:EDV36849.1, ECO:0000313|Proteomes:UP000007801};
RN [1] {ECO:0000313|EMBL:EDV36849.1, ECO:0000313|Proteomes:UP000007801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR EMBL; CH902619; EDV36849.1; -; Genomic_DNA.
DR RefSeq; XP_001960027.1; XM_001959991.2.
DR STRING; 7217.B3MH72; -.
DR EnsemblMetazoa; FBtr0116439; FBpp0114931; FBgn0088779.
DR GeneID; 6494602; -.
DR KEGG; dan:6494602; -.
DR eggNOG; KOG4641; Eukaryota.
DR HOGENOM; CLU_004280_0_0_1; -.
DR InParanoid; B3MH72; -.
DR OMA; NHVFIGR; -.
DR OrthoDB; 927694at2759; -.
DR PhylomeDB; B3MH72; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005030; F:neurotrophin receptor activity; IEA:EnsemblMetazoa.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:EnsemblMetazoa.
DR GO; GO:0046790; F:virion binding; IEA:EnsemblMetazoa.
DR GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa.
DR GO; GO:0051607; P:defense response to virus; IEA:EnsemblMetazoa.
DR GO; GO:0009597; P:detection of virus; IEA:EnsemblMetazoa.
DR GO; GO:0045087; P:innate immune response; IEA:EnsemblMetazoa.
DR GO; GO:0040011; P:locomotion; IEA:UniProt.
DR GO; GO:0002225; P:positive regulation of antimicrobial peptide production; IEA:EnsemblMetazoa.
DR GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblMetazoa.
DR GO; GO:0050688; P:regulation of defense response to virus; IEA:EnsemblMetazoa.
DR GO; GO:0008063; P:Toll signaling pathway; IEA:EnsemblMetazoa.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24366; IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS; 1.
DR PANTHER; PTHR24366:SF157; LRRNT DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00364; LRR_BAC; 8.
DR SMART; SM00365; LRR_SD22; 5.
DR SMART; SM00369; LRR_TYP; 20.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 11.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1455
FT /note="TIR domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002792916"
FT TRANSMEM 1062..1085
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1111..1248
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1269..1346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1381..1455
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1295..1327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1401..1447
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1455 AA; 162522 MW; 7A74C2FB616C8521 CRC64;
MAASALPLQL LLVLAVFWPG SRLAAGALAP KESQASQESN ASAMLGAGTG AAATVSLSGD
YSSLLSNAAI SSSVSSPAPV PAHSGPANQC SWSYNGTSSV HCALRLIERQ PGLDLQGADG
SSQLTIQCSD LYLFESSLPV AVFARLQTLE VLRLEACKLL QLPNNAFEGL ATLKSLRLST
HNSEWGPTRS LELFPDSLVG LKQLTELDLG DNNLRQLPAG FLCPVGNLQV LNLTRNRIRT
AEQLGFADMN CGSGSGSAGS ELQVLDASHN ELRSISESWG ISRLRRLQHL NLAHNNLSEL
SGEALAGLAS LRIVNLSNNH LETLPEGLFA GSKELREIHL QHNELYELPR GLFHRLEQLL
VVDLSGNQLT SNHVDNTTFA GLIRLIVLNL AHNALTRIDY RTFKELYFLQ ILNLRNNSIG
HIEDNAFLPL YNLHTLNLAE NRLHTLDDKL FNGLYVLSKL TLNNNLISVV EPAVFKNCSD
LKELDLSSNQ LNEVPRALQD LPMLRTLDLG ENQIRTFDNQ SFKNLHQLTG LRLIDNQIGN
ITVGMFQDLP RLSVLNLAKN RIQSIERGSF DKNFELEAIR LDRNFLSDIN GVFATLVSLL
WLNLSENHLV WFDYAFIPSN LKWLDIHGNY IEALGNYYKL QEEIRVKTLD ASHNRITEIG
PMSIPNTIEL LFINNNLIGN VQPNAFVDKA NLARVDLYAN QLSKLQLQQL RVAPVVAPKP
LPEFYLGGNP FECDCTMDWL QRINNLTTRQ HPRVMDMGNI ECVMPHARGA AVRPLSALRP
QDFLCRYESH CFALCHCCDF DACDCEMTCP TNCTCYHDQI WSTNVVDCGG QQTTELPRRV
PMDSSVVYLD GNNFPVLKNH AFIGRKNLRA LYVNGSQVAA IQNRTFASLA SLQLLHLADN
KLRSLHGYEF EQLSALRELY LQNNQLTTIE NATLAPLAAL ELLRIDGNRL VTLPIWQLHA
VHFGSRLRSL TLGKNPWSCR CQFLQALTSY VADNALIVQD AQDIYCMALS SSSSRGSSNL
EDGYAQESDM EKRELDFNAT GAACTDYYSG GSMLQHGIPE SYIPLLAAAL ALVFLLVVIA
MVFAFRESLR IWLFAHYGVR VFGPRCEESE KLYDALLLHS AKDSEFVCQH LAGQLETGRP
PLRVCLQHRD LAHDATHYQL LEATRVSRRV VILLTRNFLQ TEWARCELRR SVHDALRGRP
QKLVIIEEPE VAFEAESDIE LLPYLKTSAV HRIRRSDRHF WEKLRYALPV DYPTFRGNNY
TLELDHHHNH ERVKQPASPG LLYRQAPPPA YDGVPPTAQQ QQQQQQQNPG ALEQNYSTAT
TATPSPRPQR RDVGPAPGVG PGAGNHHLRA EYYQHHGMRP PSEHIYSSID SDYSTLDNEQ
HMLMMPGGHP MEGAQRAQTW RPKREQLQQQ HPQVQAGTLG SKASQQHQQQ QQQAQQQTGS
VAGQQQGPHV QAYLV
//