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Database: UniProt
Entry: B3MH72_DROAN
LinkDB: B3MH72_DROAN
Original site: B3MH72_DROAN 
ID   B3MH72_DROAN            Unreviewed;      1455 AA.
AC   B3MH72;
DT   02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT   02-SEP-2008, sequence version 1.
DT   24-JAN-2024, entry version 97.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   Name=Dana\GF11739 {ECO:0000313|EMBL:EDV36849.1};
GN   Synonyms=dana_GLEANR_11772 {ECO:0000313|EMBL:EDV36849.1};
GN   ORFNames=GF11739 {ECO:0000313|EMBL:EDV36849.1};
OS   Drosophila ananassae (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7217 {ECO:0000313|EMBL:EDV36849.1, ECO:0000313|Proteomes:UP000007801};
RN   [1] {ECO:0000313|EMBL:EDV36849.1, ECO:0000313|Proteomes:UP000007801}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA   Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA   Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA   Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA   Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA   Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA   Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA   David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA   Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA   Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA   Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA   Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA   Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA   Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA   Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA   Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA   Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA   Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA   Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA   Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA   McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA   Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA   Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA   Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA   Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA   Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA   Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA   Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA   Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA   Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA   Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA   Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA   Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA   Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA   Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA   Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA   Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA   Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA   Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA   Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA   Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA   D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA   Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA   Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA   Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA   Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA   Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA   Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA   Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA   Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA   Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA   Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA   Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA   Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA   Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA   Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA   Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA   Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC       pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC   -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC       {ECO:0000256|ARBA:ARBA00009634}.
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DR   EMBL; CH902619; EDV36849.1; -; Genomic_DNA.
DR   RefSeq; XP_001960027.1; XM_001959991.2.
DR   STRING; 7217.B3MH72; -.
DR   EnsemblMetazoa; FBtr0116439; FBpp0114931; FBgn0088779.
DR   GeneID; 6494602; -.
DR   KEGG; dan:6494602; -.
DR   eggNOG; KOG4641; Eukaryota.
DR   HOGENOM; CLU_004280_0_0_1; -.
DR   InParanoid; B3MH72; -.
DR   OMA; NHVFIGR; -.
DR   OrthoDB; 927694at2759; -.
DR   PhylomeDB; B3MH72; -.
DR   Proteomes; UP000007801; Unassembled WGS sequence.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:EnsemblMetazoa.
DR   GO; GO:0005030; F:neurotrophin receptor activity; IEA:EnsemblMetazoa.
DR   GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:EnsemblMetazoa.
DR   GO; GO:0046790; F:virion binding; IEA:EnsemblMetazoa.
DR   GO; GO:0007411; P:axon guidance; IEA:EnsemblMetazoa.
DR   GO; GO:0051607; P:defense response to virus; IEA:EnsemblMetazoa.
DR   GO; GO:0009597; P:detection of virus; IEA:EnsemblMetazoa.
DR   GO; GO:0045087; P:innate immune response; IEA:EnsemblMetazoa.
DR   GO; GO:0040011; P:locomotion; IEA:UniProt.
DR   GO; GO:0002225; P:positive regulation of antimicrobial peptide production; IEA:EnsemblMetazoa.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblMetazoa.
DR   GO; GO:0050688; P:regulation of defense response to virus; IEA:EnsemblMetazoa.
DR   GO; GO:0008063; P:Toll signaling pathway; IEA:EnsemblMetazoa.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR000483; Cys-rich_flank_reg_C.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR24366; IG(IMMUNOGLOBULIN) AND LRR(LEUCINE RICH REPEAT) DOMAINS; 1.
DR   PANTHER; PTHR24366:SF157; LRRNT DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF13855; LRR_8; 6.
DR   Pfam; PF01582; TIR; 1.
DR   SMART; SM00364; LRR_BAC; 8.
DR   SMART; SM00365; LRR_SD22; 5.
DR   SMART; SM00369; LRR_TYP; 20.
DR   SMART; SM00082; LRRCT; 1.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 3.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS51450; LRR; 11.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007801};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..1455
FT                   /note="TIR domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002792916"
FT   TRANSMEM        1062..1085
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1111..1248
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   REGION          1269..1346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1381..1455
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1295..1327
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1401..1447
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1455 AA;  162522 MW;  7A74C2FB616C8521 CRC64;
     MAASALPLQL LLVLAVFWPG SRLAAGALAP KESQASQESN ASAMLGAGTG AAATVSLSGD
     YSSLLSNAAI SSSVSSPAPV PAHSGPANQC SWSYNGTSSV HCALRLIERQ PGLDLQGADG
     SSQLTIQCSD LYLFESSLPV AVFARLQTLE VLRLEACKLL QLPNNAFEGL ATLKSLRLST
     HNSEWGPTRS LELFPDSLVG LKQLTELDLG DNNLRQLPAG FLCPVGNLQV LNLTRNRIRT
     AEQLGFADMN CGSGSGSAGS ELQVLDASHN ELRSISESWG ISRLRRLQHL NLAHNNLSEL
     SGEALAGLAS LRIVNLSNNH LETLPEGLFA GSKELREIHL QHNELYELPR GLFHRLEQLL
     VVDLSGNQLT SNHVDNTTFA GLIRLIVLNL AHNALTRIDY RTFKELYFLQ ILNLRNNSIG
     HIEDNAFLPL YNLHTLNLAE NRLHTLDDKL FNGLYVLSKL TLNNNLISVV EPAVFKNCSD
     LKELDLSSNQ LNEVPRALQD LPMLRTLDLG ENQIRTFDNQ SFKNLHQLTG LRLIDNQIGN
     ITVGMFQDLP RLSVLNLAKN RIQSIERGSF DKNFELEAIR LDRNFLSDIN GVFATLVSLL
     WLNLSENHLV WFDYAFIPSN LKWLDIHGNY IEALGNYYKL QEEIRVKTLD ASHNRITEIG
     PMSIPNTIEL LFINNNLIGN VQPNAFVDKA NLARVDLYAN QLSKLQLQQL RVAPVVAPKP
     LPEFYLGGNP FECDCTMDWL QRINNLTTRQ HPRVMDMGNI ECVMPHARGA AVRPLSALRP
     QDFLCRYESH CFALCHCCDF DACDCEMTCP TNCTCYHDQI WSTNVVDCGG QQTTELPRRV
     PMDSSVVYLD GNNFPVLKNH AFIGRKNLRA LYVNGSQVAA IQNRTFASLA SLQLLHLADN
     KLRSLHGYEF EQLSALRELY LQNNQLTTIE NATLAPLAAL ELLRIDGNRL VTLPIWQLHA
     VHFGSRLRSL TLGKNPWSCR CQFLQALTSY VADNALIVQD AQDIYCMALS SSSSRGSSNL
     EDGYAQESDM EKRELDFNAT GAACTDYYSG GSMLQHGIPE SYIPLLAAAL ALVFLLVVIA
     MVFAFRESLR IWLFAHYGVR VFGPRCEESE KLYDALLLHS AKDSEFVCQH LAGQLETGRP
     PLRVCLQHRD LAHDATHYQL LEATRVSRRV VILLTRNFLQ TEWARCELRR SVHDALRGRP
     QKLVIIEEPE VAFEAESDIE LLPYLKTSAV HRIRRSDRHF WEKLRYALPV DYPTFRGNNY
     TLELDHHHNH ERVKQPASPG LLYRQAPPPA YDGVPPTAQQ QQQQQQQNPG ALEQNYSTAT
     TATPSPRPQR RDVGPAPGVG PGAGNHHLRA EYYQHHGMRP PSEHIYSSID SDYSTLDNEQ
     HMLMMPGGHP MEGAQRAQTW RPKREQLQQQ HPQVQAGTLG SKASQQHQQQ QQQAQQQTGS
     VAGQQQGPHV QAYLV
//
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