ID B3MHA9_DROAN Unreviewed; 1366 AA.
AC B3MHA9;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=Anaphase-promoting complex subunit 4-like WD40 domain-containing protein {ECO:0000259|Pfam:PF12894};
GN Name=Dana\GF13180 {ECO:0000313|EMBL:EDV36886.1};
GN Synonyms=dana_GLEANR_13194 {ECO:0000313|EMBL:EDV36886.1};
GN ORFNames=GF13180 {ECO:0000313|EMBL:EDV36886.1};
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217 {ECO:0000313|EMBL:EDV36886.1, ECO:0000313|Proteomes:UP000007801};
RN [1] {ECO:0000313|EMBL:EDV36886.1, ECO:0000313|Proteomes:UP000007801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
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DR EMBL; CH902619; EDV36886.1; -; Genomic_DNA.
DR RefSeq; XP_001960064.1; XM_001960028.2.
DR STRING; 7217.B3MHA9; -.
DR EnsemblMetazoa; FBtr0117880; FBpp0116372; FBgn0090213.
DR GeneID; 6496023; -.
DR KEGG; dan:6496023; -.
DR eggNOG; KOG2247; Eukaryota.
DR HOGENOM; CLU_003002_2_0_1; -.
DR InParanoid; B3MHA9; -.
DR OMA; CTGFGWD; -.
DR OrthoDB; 5476164at2759; -.
DR PhylomeDB; B3MHA9; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0097730; C:non-motile cilium; IEA:EnsemblMetazoa.
DR GO; GO:0060271; P:cilium assembly; IEA:EnsemblMetazoa.
DR GO; GO:0035721; P:intraciliary retrograde transport; IEA:InterPro.
DR Gene3D; 1.25.40.470; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR040379; WDR19/dyf-2.
DR InterPro; IPR039468; WDR19_WD40_rpt.
DR PANTHER; PTHR14920; OSMOTIC AVOIDANCE ABNORMAL PROTEIN 1/WD REPEAT MEMBRANE PROTEIN; 1.
DR PANTHER; PTHR14920:SF0; WD REPEAT-CONTAINING PROTEIN 19 ISOFORM X2; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF15911; WD40_3; 1.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF69322; Tricorn protease domain 2; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007801}.
FT DOMAIN 280..344
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
SQ SEQUENCE 1366 AA; 153601 MW; B7760C567C6B4A91 CRC64;
MSFEKILYKY DEPHGIGDVY FIWQKALLAT TGTDGSVALY NRQGQLVQRI ILAGLCSGFA
WDHDGDVLGI ITSGSPNITL WDYETQEKMS VETGLRDPLT CILWSKQQQL LAVGTGRGNL
AIYNHSSGKR PTPVLGKHSK RITCGAWSAQ NLLALGSEDK SFSLSNEDGD TVRVVQLRDA
PTDMYFAEMA NDDRIAGDNA ISMIIGKRTL FLYYLPEPEN PTELGFQSRY GSLMQHKWFG
DGYILLGFSN GHVVAISTHP KDVGQELWQV KNHKDTLSGL AYCPTLDIVA SCGDDNIKIH
SITNLQETER IITVPDHAGV QMIDWSPDGQ LLAVTTNSGT VYIYVTKLPH LFAVSAPRIV
LLSSLAEVSI YVYAPDKSKS LPFRLPLEGE PTFMAVGPYN FAAGIEKHVW FYDLGKSLGE
EPRPLSERDF PRSIASMRLN ADYCAALCPP QLILQAITAD NPNCKDKLQA VFPNALPNMP
SDAVITCFAL TQELLIFATD IGHLVFYSLE KWESCTIYRH SMGIRQLNVD IEGTKTIFID
DHAQGYVFLP AVEEALLIPE MPKECLGCLW DLTQPNIFIS YDTRMVTTHV FVRHSVQGTY
ALKVGESKLN PGQFPLLLCG GEMALHVDGG QYATQSLSTH VVNPSNSQTA NLQMLLRLRN
YEEAFKLCKQ MNQTSAWREF GEQAISDLEP DIAIRAYRQL GDAALVNALM ELRYVEDLDM
LIGCCCMLLS QYEQAKEHML KGVYNRAALE LCRDLLQWDQ ALLLAHKHDP QEVPFIAREY
AQQLEFTGNY ADALYHYEKG YKEDLINNKD SEQSALMDAS PEFEDHVRLC KMGIARTSIR
AGDFRRGIQY AVELEDRQLL FDCAELLATV GHLTEAAGLY ERGGFYDEAC GHYIALKMWH
KANNILPKVK STKLHAAYAK AKENDGHFEE AIKSYRVAGD LDACVRIYLD HLCDPHAASE
IVLESRSMDS AKLLAKFYQK IGDVEQALQF LVICGCVEEA FALAQRHNKL RRHGELLERY
ENAKSSDYLA LAHYFESEKY TLLAGKYYFL AREFTKALRF LLKASAFNNE EQGALSLAID
CVATSNNEQL ATQLIEFLLG EVDGVPKDPR YLFRLYMARK HYKDAAKTAV IIANQEQLAG
NYKSARDLLY SMYQELRRNN LSVTAEMRHQ FILLHRYTLV RIHVKLGNHL LAAKLLVQVA
ACISQFPEHI IPILTSTVIE CHRAGLKKSA FTYASTLMRP DYRNQLDPRY AKKIESIVRK
APKGIKQLRD EIDDETMECP ICDSNLANME VTCYSCKTTL PICIATGQHI IKQLMTSCPQ
CDFLCFRAEM ENILSENGEC PMCGERVAPE QLLDVEDIRP YILAAS
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