ID B3MKW8_DROAN Unreviewed; 3589 AA.
AC B3MKW8;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 127.
DE SubName: Full=Uncharacterized protein, isoform A {ECO:0000313|EMBL:EDV30626.1};
DE SubName: Full=Uncharacterized protein, isoform C {ECO:0000313|EMBL:KPU72961.1};
GN Name=Dana\GF14947 {ECO:0000313|EMBL:EDV30626.1};
GN Synonyms=dana_GLEANR_15713 {ECO:0000313|EMBL:EDV30626.1};
GN ORFNames=GF14947 {ECO:0000313|EMBL:EDV30626.1};
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217 {ECO:0000313|EMBL:EDV30626.1, ECO:0000313|Proteomes:UP000007801};
RN [1] {ECO:0000313|EMBL:EDV30626.1, ECO:0000313|Proteomes:UP000007801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TSC#14024-0371.13 {ECO:0000313|EMBL:EDV30626.1}, and Tucson
RC 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
RN [2] {ECO:0000313|EMBL:EDV30626.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSC#14024-0371.13 {ECO:0000313|EMBL:EDV30626.1};
RX PubMed=18057021; DOI=10.1093/bioinformatics/btm542;
RA Zimin A.V., Smith D.R., Sutton G., Yorke J.A.;
RT "Assembly reconciliation.";
RL Bioinformatics 24:42-45(2008).
RN [3] {ECO:0000313|EMBL:EDV30626.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TSC#14024-0371.13 {ECO:0000313|EMBL:EDV30626.1};
RG FlyBase;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; CH902620; EDV30626.1; -; Genomic_DNA.
DR EMBL; CH902620; KPU72961.1; -; Genomic_DNA.
DR RefSeq; XP_001961405.1; XM_001961369.2.
DR RefSeq; XP_014761810.1; XM_014906324.1.
DR SMR; B3MKW8; -.
DR STRING; 7217.B3MKW8; -.
DR EnsemblMetazoa; FBtr0119647; FBpp0118139; FBgn0091972.
DR EnsemblMetazoa; FBtr0386802; FBpp0346640; FBgn0091972.
DR GeneID; 6497762; -.
DR KEGG; dan:6497762; -.
DR eggNOG; KOG1217; Eukaryota.
DR HOGENOM; CLU_000125_0_0_1; -.
DR OMA; CMKLEIM; -.
DR OrthoDB; 5474074at2759; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:EnsemblMetazoa.
DR GO; GO:0031901; C:early endosome membrane; IEA:EnsemblMetazoa.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005112; F:Notch binding; IEA:EnsemblMetazoa.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:UniProt.
DR GO; GO:0045167; P:asymmetric protein localization involved in cell fate determination; IEA:EnsemblMetazoa.
DR GO; GO:0046716; P:muscle cell cellular homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; IEA:EnsemblMetazoa.
DR GO; GO:0035152; P:regulation of tube architecture, open tracheal system; IEA:EnsemblMetazoa.
DR GO; GO:0016360; P:sensory organ precursor cell fate determination; IEA:EnsemblMetazoa.
DR CDD; cd00033; CCP; 3.
DR CDD; cd00037; CLECT; 1.
DR CDD; cd00041; CUB; 3.
DR CDD; cd00054; EGF_CA; 12.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 5.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 2.
DR Gene3D; 2.10.25.10; Laminin; 17.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 3.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 4.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR003410; HYR_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR12916; CYTOCHROME C OXIDASE POLYPEPTIDE VIC-2; 1.
DR PANTHER; PTHR12916:SF4; NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1-RELATED; 1.
DR Pfam; PF00431; CUB; 3.
DR Pfam; PF00008; EGF; 9.
DR Pfam; PF07645; EGF_CA; 2.
DR Pfam; PF07699; Ephrin_rec_like; 7.
DR Pfam; PF00754; F5_F8_type_C; 2.
DR Pfam; PF12661; hEGF; 3.
DR Pfam; PF02494; HYR; 3.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR Pfam; PF00084; Sushi; 4.
DR SMART; SM00032; CCP; 8.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00042; CUB; 3.
DR SMART; SM00181; EGF; 21.
DR SMART; SM00179; EGF_CA; 15.
DR SMART; SM01411; Ephrin_rec_like; 7.
DR SMART; SM00231; FA58C; 2.
DR SMART; SM00192; LDLa; 1.
DR SMART; SM00208; TNFR; 3.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 6.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 12.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 4.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 10.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS01180; CUB; 3.
DR PROSITE; PS00022; EGF_1; 15.
DR PROSITE; PS01186; EGF_2; 12.
DR PROSITE; PS50026; EGF_3; 16.
DR PROSITE; PS01187; EGF_CA; 6.
DR PROSITE; PS01285; FA58C_1; 1.
DR PROSITE; PS50022; FA58C_3; 2.
DR PROSITE; PS50825; HYR; 3.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
DR PROSITE; PS50923; SUSHI; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..3589
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014298541"
FT TRANSMEM 3447..3473
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..168
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 210..322
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 326..438
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 439..551
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 550..611
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 612..672
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 673..733
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 734..792
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 792..830
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 829..977
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 1049..1108
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1298..1444
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 1463..1549
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 1550..1633
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 2021..2057
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2059..2095
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2097..2135
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2137..2176
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2178..2214
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2216..2251
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2253..2289
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2291..2327
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2329..2367
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2369..2405
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2407..2444
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2446..2482
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2484..2520
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2522..2558
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 2799..2881
FT /note="HYR"
FT /evidence="ECO:0000259|PROSITE:PS50825"
FT DOMAIN 3407..3442
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 172..184
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 179..197
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 191..206
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 439..466
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 552..595
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 675..718
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 704..731
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1079..1106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2047..2056
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2085..2094
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2106..2123
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2125..2134
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2166..2175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2204..2213
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2220..2230
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2241..2250
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2279..2288
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2317..2326
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2338..2355
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2357..2366
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2395..2404
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2434..2443
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2472..2481
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2510..2519
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 2548..2557
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3410..3420
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3432..3441
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 3589 AA; 391215 MW; 6213FA6D176F68EE CRC64;
MNQPTAANSH WLAALLSSLL FFNLLHSIGA DEAFSCPNGW ELRGLNCYKY FNIKHSWEKS
AELCRRYGAE LVAIDSFVEN NETLSIARAS DPNQRASDKY WLGLASLDDL RTNTLESASG
ALISQYSGYW SLNQPNADSG ECVAAGFAGK SQSWDLGTCE SLLPFMCRAQ ACPQGALHCA
NGKCINQAFK CDGSDDCGDG TDELDCPAQC HFHMQSGGDV IETPNYPHKY SALSKCKWTL
EGPLGSNIIL QFQDFETEKT FDTVQILVGG RTEDKSVSLA TLSGKQDLTT QPFVSASNFM
IVKFTTDGSV ERKGFRATWK TEAKNCGGTL KATLQRQILT SSNYPKQYPG GLECLYLIKA
QPGRIISIEV DDLDVAEGRD YLLIRDGDSP MSRTIAKLTG KTAQNERIII STGNSLYLYF
KSSLGEAGKG FSLRYIQGCK ATITARNGTV TSPAFGLADY PKNQECYFTI RNNARAPLSL
KFDKFTVHKS DNVQVFDGSS TSGLRLHSGN GFTGTAAPKL TLTASSGEML IKFTSDALHN
AAGWSATFSA DCPELQPGIG ALASSRDTAF GTLVSFTCPI GQEFATGKTR LVTECLRGGN
WSVSYIPKCQ EVYCGPVPQI DNGFSIGSSN VTYRGIAMYQ CYAGFAFASG TPIEKISCLP
DGRWERQPNC MASQCAPLPE VAHANVTLLN GGGRSYGTIV QYVCESGYER NGHPVLTCMS
NGTWSGDVPR CSRKRCYEFP DIDNGFVVDS TREYLFGDEA RVQCYKGYKL IGSNIMRCSE
AQKFEQPPIC EDINECSSSQ CDLTTTECQN TNGSFHCQCR AGFTATTECR PVADLGLGNG
GIPDDSISSS VSEQGYSKTQ LRLNTNGWCG GSSEPGANWI LIDLKAPTIL RGFRTMSVQR
PDGNVAFSSA VRLQYTNDLT DVFKDYANPD GTAVEFRILE PTLSILNLPL PIEARYIRFR
IQDYVGAPCI RMELMGCTRL DCVDINECSK NNGGCDQKCI NSPGGYACGC NTGYQLYTSN
GTAGFHLERS ESGERDGDTY QRNKTCVPVM CPELDAPENG QLLSDKNDYH FGDVVRFQCH
FGYIMSGSST ALCLSSGQWN ASVPECNYAK CVSLPDDKLE GLTVARPDPE SVLVPFRDNV
TITCGSAGRQ LRATASSGFR QCVYDPKPGL PDYWLSGMQP SCPRVDCYAP MPTPGAEYGQ
FVDTRFQSSF FFGCQNTFKL AGQTGRNDNV VRCGADGIWD FGDLRCEGPV CEDPGRPADG
RQIARSYEQS SEVYFGCNRP GYILINPRPI TCIREPECKV IRPLGLSSGR IPDSAINATS
ERPNYEAKNI RLNSATGWCG KQEAFTYVSV DLGQIYRVKA ILVKGVVTND IVGRPTEIRF
FYKQAESENY VVYFPNFNLT MRDPGNYGEL AMITLPKYVQ ARFVILGIVS YMDNACLKFE
LMGCEEPKHE PLLGYDYGYS PCVDNEPPIF QNCPQQPIVV RRDENGGVLP VNFTEPTAVD
NSGSIARLEI KPQNFRTPSY VFKDTVVKYV AFDYDGNVAI CEINITVPDV TPPLLQCPQS
YVIELVDRQE SYDVNFNDTR KRIKTSDDTG EVRLQFSPER ATIKIGNFEN VTVTATDKFN
NRASCHFQVS LKASPCVDWE LQPPANGAIN CLPGDRGIEC IATCKPGFRF TDGEPLKTFS
CETSRLWRPT SVVPDCVSEN TEQAAYHVTA TITYRANGAV AQSCLGQYQD VLAQHYTGLN
QLLSQRCSAV NVNMNVTFVK SVPMLLEENV VKMDFILSIL PAVRQPQLYD LCGSTLNLIF
DLSVPYASAV IDDLLNIANI GNQCPPLRAL KSQISRGFSC NVGEVLNMDT SDVPRCLHCP
AGTYVSEGQN SCTYCPRGYY QNRDRQGTCV RCPAGTYTKE EGSKAQADCI PVCGYGTYSP
TGLVPCLECP RNSFSAEPPT GGFKDCQACP AQTFTYQPAA SNRDLCRAKC APGTYSATGL
APCSLCPLHH YQGSAGSQSC NECPSNMRTD TAGSKGREQC KAVVCGEGAC QHGGLCVPMG
HDIQCFCPAG FSGRRCEQDI DECASQPCYN GGQCKDLPQG YRCDCQPGYS GINCQEEASD
CENDTCPTRA MCKNEPGFKN VTCLCRSGYT GDQCDVTIDP CTANGNPCGN GASCQALQQG
RYKCECLPGW EGIHCELNIN DCSENPCLLG ANCTDLVNDF QCACPPGFTG KRCEQKIDLC
LSEPCKHGTC VDRLFDHECV CHPGWTGAAC DVNIDDCEIR PCANEGTCVD LVDGYSCNCE
PGYTGKNCQH TIDDCASNPC QHGATCVDQL DGFSCKCRPG YVGLSCEAEI DECLSDPCNP
VGTERCLDKD NKFECVCRDG FKGQLCETDI DDCEAQPCLN NGLCRDRVGG FECGCEPGWS
GMRCEQQVTT CNLQAPCQND AHCIDLFQDY FCVCPSGTDG KNCETAPERC IGDPCMHGGK
CQDFGSGLNC SCPADYSGIG CQYEYDACEE KVCQNGATCV DNGAGYSCQC PPGFTGRNCE
QDIVDCKDNS CPPGASCVDL TNGFYCQCPF NMTGDDCRKA IQVDYDLYFS DPSRSTAAQV
VPFATGEANS LTVAMWVQFA QKDDPGIFFT LYGVESARMT QRRRMLLQAH SSGVQISLFE
DQSDAFLSFG EYTSVNDGQW HHVAVVWDGI SGQLQLITEG LIASKMEYGA GGSLPGYLWA
VLGRPQPYGL TNELAYSDAG FQGTITKAQV WARALDITSE IQKQVRDCRS EPVLYPGLIL
NWAGYEVTSG GVERNVPSLC GQRKCPVGYT GPNCQQLVVD KEPPVVEHCP GDLWVIAKNG
SAMVTWDEPH FSDNIGVTKI YERNGHRSGT TLLWGSYDIT YIASDAAGNT ASCSFKVSLL
TDFCPSLADP VGGSQVCKDW GAGGQFKVCE IACNTGLRFS EPVPEFYTCG AEGFWRPTRE
PSMPLVYPSC SPSKPAQRVF RIKMLFPSDV LCNKAGQAVL RQKVTNSVNG LNRDWNFCSY
AVEGTRECKD IQIDVKCDHY RAAQNNRVRR QAKDGGVYVM EAELPVVNED DDDLTLTGRQ
GRQQTGGDTY TLEIAFPAVN DPVIHTSTGE RSSVKQLLEK LILEDDQFAV QDILPNTVPD
PASLELGSEY ACPVGQVVMI PDCVPCAIGT FYDSANKTCI PCARGTYQSE AGQQQCSKCP
VIAGRPGVTA GPGARSAADC KERCPAGKYF DAETGLCRSC GHGFFQSNEG AFGCELCGLG
QTTRSTEATS RKECRDECSS GQQLGADGRC EPCPRGTYRL QGVQPSCAAC PLGRTTPKVG
ASSVEECTLP VCSPGTYLNA TLNMCIECRK GFYQSESQQT SCLQCPPNHS TKIAGATSKS
ECTNPCEHIA EGKPHCDVNA YCIMVPETSD FKCECKPGFN GTGMACTDMC EGFCENSGTC
VKDLKGTPSC RCVGSFTGPH CAERSEFAYI AGGIAGAVIF IIIIVLLIWM ICVRSTKRRD
PKKMLTPAID QTGSQVNFYY GAHTPYAESI APSHHSTYAH YYDDEEDGWE MPNFYNETYM
KDGLHGGKMS TLARSNASLY GTKEDLYDRL KRHAYTGKKE KSDSDSEVQ
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