ID B3MZ23_DROAN Unreviewed; 1049 AA.
AC B3MZ23;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE RecName: Full=Short gastrulation {ECO:0008006|Google:ProtNLM};
GN Name=Dana\GF22248 {ECO:0000313|EMBL:EDV32867.2};
GN Synonyms=dana_GLEANR_6223 {ECO:0000313|EMBL:EDV32867.2};
GN ORFNames=GF22248 {ECO:0000313|EMBL:EDV32867.2};
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217 {ECO:0000313|EMBL:EDV32867.2, ECO:0000313|Proteomes:UP000007801};
RN [1] {ECO:0000313|EMBL:EDV32867.2, ECO:0000313|Proteomes:UP000007801}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000313|Proteomes:UP000007801};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RA Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B., Markow T.A.,
RA Kaufman T.C., Kellis M., Gelbart W., Iyer V.N., Pollard D.A., Sackton T.B.,
RA Larracuente A.M., Singh N.D., Abad J.P., Abt D.N., Adryan B., Aguade M.,
RA Akashi H., Anderson W.W., Aquadro C.F., Ardell D.H., Arguello R.,
RA Artieri C.G., Barbash D.A., Barker D., Barsanti P., Batterham P.,
RA Batzoglou S., Begun D., Bhutkar A., Blanco E., Bosak S.A., Bradley R.K.,
RA Brand A.D., Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A., Daub J.,
RA David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H., Edwards K.,
RA Eickbush T., Evans J.D., Filipski A., Findeiss S., Freyhult E., Fulton L.,
RA Fulton R., Garcia A.C., Gardiner A., Garfield D.A., Garvin B.E., Gibson G.,
RA Gilbert D., Gnerre S., Godfrey J., Good R., Gotea V., Gravely B.,
RA Greenberg A.J., Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A.,
RA Haerty W., Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A., Hubisz M.J.,
RA Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S., Jeck W.R.,
RA Johnson J., Jones C.D., Jordan W.C., Karpen G.H., Kataoka E.,
RA Keightley P.D., Kheradpour P., Kirkness E.F., Koerich L.B., Kristiansen K.,
RA Kudrna D., Kulathinal R.J., Kumar S., Kwok R., Lander E., Langley C.H.,
RA Lapoint R., Lazzaro B.P., Lee S.J., Levesque L., Li R., Lin C.F., Lin M.F.,
RA Lindblad-Toh K., Llopart A., Long M., Low L., Lozovsky E., Lu J., Luo M.,
RA Machado C.A., Makalowski W., Marzo M., Matsuda M., Matzkin L.,
RA McAllister B., McBride C.S., McKernan B., McKernan K., Mendez-Lago M.,
RA Minx P., Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E.,
RA Negre B., Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S., Pesole G.,
RA Phillippy A.M., Ponting C.P., Pop M., Porcelli D., Powell J.R.,
RA Prohaska S., Pruitt K., Puig M., Quesneville H., Ram K.R., Rand D.,
RA Rasmussen M.D., Reed L.K., Reenan R., Reily A., Remington K.A.,
RA Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H., Rohde C., Rozas J.,
RA Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L., Sanchez-Gracia A.,
RA Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C., Schlenke T.,
RA Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M., Sisneros N.B.,
RA Smith C.D., Smith T.F., Spieth J., Stage D.E., Stark A., Stephan W.,
RA Strausberg R.L., Strempel S., Sturgill D., Sutton G., Sutton G.G., Tao W.,
RA Teichmann S., Tobari Y.N., Tomimura Y., Tsolas J.M., Valente V.L.,
RA Venter E., Venter J.C., Vicario S., Vieira F.G., Vilella A.J.,
RA Villasante A., Walenz B., Wang J., Wasserman M., Watts T., Wilson D.,
RA Wilson R.K., Wing R.A., Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G.,
RA Yamamoto D., Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E.,
RA Zhang P., Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Blye J., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the chordin family.
CC {ECO:0000256|ARBA:ARBA00007156}.
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DR EMBL; CH902632; EDV32867.2; -; Genomic_DNA.
DR RefSeq; XP_001966579.2; XM_001966543.2.
DR AlphaFoldDB; B3MZ23; -.
DR STRING; 7217.B3MZ23; -.
DR EnsemblMetazoa; FBtr0126948; FBpp0125440; FBgn0099246.
DR eggNOG; ENOG502QR4J; Eukaryota.
DR HOGENOM; CLU_1020361_0_0_1; -.
DR InParanoid; B3MZ23; -.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009790; P:embryo development; IEA:UniProt.
DR GO; GO:0007389; P:pattern specification process; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 6.20.200.20; -; 1.
DR InterPro; IPR016353; Chordin.
DR InterPro; IPR010895; CHRD.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46526; CHORDIN; 1.
DR PANTHER; PTHR46526:SF1; CHORDIN; 1.
DR Pfam; PF07452; CHRD; 3.
DR Pfam; PF00093; VWC; 4.
DR PIRSF; PIRSF002496; Chordin; 2.
DR SMART; SM00754; CHRD; 3.
DR SMART; SM00214; VWC; 4.
DR SUPFAM; SSF57603; FnI-like domain; 4.
DR PROSITE; PS50933; CHRD; 3.
DR PROSITE; PS01208; VWFC_1; 2.
DR PROSITE; PS50184; VWFC_2; 2.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473, ECO:0000256|PROSITE-
KW ProRule:PRU00230}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007801};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 93..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 343..476
FT /note="CHRD"
FT /evidence="ECO:0000259|PROSITE:PS50933"
FT DOMAIN 479..593
FT /note="CHRD"
FT /evidence="ECO:0000259|PROSITE:PS50933"
FT DOMAIN 597..718
FT /note="CHRD"
FT /evidence="ECO:0000259|PROSITE:PS50933"
FT DOMAIN 748..811
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 947..1028
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1030..1049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1049 AA; 116478 MW; 4C2BB192C0151985 CRC64;
MAKKQQQKPQ KQRKWSSAVG GSETLATATG TVMLLDRSQC HAHLKDDTTT AFYTCSTTNT
TTNNCNNNIN TTNNLQHHRN MEKVRLPVMI CHLRHLIAVA GLLLLLVAVG GAEGRRHAPL
MFEESDTGRR SNRPAVTECQ FGKVLRELGS TWYADLGPPF GVMYCIRCEC VAIPKKRRIV
ARVQCRNIKN ECPPAKCDDP ISLPGKCCKT CPGDRNDTDV ALDVPVPNEE EERNMKHYAA
LLTGRTSYFL KGEEMKSMYT TYNPHNVVAT ARFLFHKKNL YYSFYTSSRA GRPRAIQFLD
DAGVILEEHH LETSLMGTWS DYHKATRIIC GVGRQRHKKK ALIKELFSSL LEPQVLPGGK
IDPQLAGAGG TAIVSTSSGA ASSMHLTLVF NGVFGAEEFS DAPVTVRIEL PERKELVFDE
VPRVRKPSAE INVLELSSPI SIQNLRLMSR GKLLLTVESK KYPQLRIQGH IVTRASCEIF
QTLLAPHSPD STTKSSGLAW VYLNTDGSLA YNIETEHMST RDRPNISLIE EQGKRRAKLE
DLSPSFNFNQ AIGSVEKLGP KVLESLYAGE LGVNVGTEHE TSLIRGRLVP RPVADARDSA
EPILLKRQEH ADPQNPHSVG MAWMSIDNEC NLHYEVTLNG VPAQDLQLYL EEKPIEAIGA
PVTRKLLEEF NGSYLEGFFL SMPSAELIKL EMSVCYLEVH AKHSKQLLLR GKLKSTKVPS
HCFPVYTDNN VPVPGDHNDN HLVASGEAKC FHSGRFYNES EQWRSAQDSC QMCACLRGQS
SCEVIKCPAV KCRAGLEQLL QREGECCPSC VPKRDAEWLG LNPAQSSSGG NATDSSRTRG
CRLGDQFHAA GASWHPFLPP NGFDTCTTCS CDPLTLEIRC PRLVCPPLQC SEKLAYRPDK
KACCKICPEG KQSTTGHKSA PNNPNVLQDQ AMQRTPGHSA EEALANGGCK VVNKVYENGQ
EWHPVLMSHG EQKCIKCRCK DSKVNCDRKR CSRSTCQQQT RVTSKRRLFE KPDAAAPAID
ECCSTQCRRS RRHHKRQPHH QQKTGAGSS
//
