GenomeNet

Database: UniProt
Entry: B3NUC9
LinkDB: B3NUC9
Original site: B3NUC9 
ID   UBA5_DROER              Reviewed;         402 AA.
AC   B3NUC9;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   13-FEB-2019, entry version 50.
DE   RecName: Full=Ubiquitin-like modifier-activating enzyme 5;
DE            Short=Ubiquitin-activating enzyme 5;
GN   ORFNames=GG18422;
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14021-0224.01;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: E1-like enzyme which activates UFM1. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family. UBA5
CC       subfamily. {ECO:0000305}.
DR   EMBL; CH954180; EDV46044.1; -; Genomic_DNA.
DR   RefSeq; XP_001977117.1; XM_001977081.2.
DR   SMR; B3NUC9; -.
DR   PRIDE; B3NUC9; -.
DR   EnsemblMetazoa; FBtr0138476; FBpp0136968; FBgn0110637.
DR   GeneID; 6551372; -.
DR   KEGG; der:6551372; -.
DR   FlyBase; FBgn0110637; Dere\GG18422.
DR   KO; K12164; -.
DR   OMA; ETHNYNI; -.
DR   OrthoDB; 1092362at2759; -.
DR   PhylomeDB; B3NUC9; -.
DR   Proteomes; UP000008711; Unassembled WGS sequence.
DR   GO; GO:0019008; C:molybdopterin synthase complex; IEA:EnsemblMetazoa.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008641; F:ubiquitin-like modifier activating enzyme activity; IEA:InterPro.
DR   GO; GO:0050905; P:neuromuscular process; IEA:EnsemblMetazoa.
DR   InterPro; IPR029752; D-isomer_DH_CS1.
DR   InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR   InterPro; IPR035985; Ubiquitin-activating_enz.
DR   Pfam; PF00899; ThiF; 1.
DR   SUPFAM; SSF69572; SSF69572; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Metal-binding; Nucleotide-binding;
KW   Ubl conjugation pathway; Zinc.
FT   CHAIN         1    402       Ubiquitin-like modifier-activating enzyme
FT                                5.
FT                                /FTId=PRO_0000391942.
FT   ACT_SITE    248    248       Glycyl thioester intermediate.
FT                                {ECO:0000250}.
FT   METAL       224    224       Zinc. {ECO:0000250}.
FT   METAL       227    227       Zinc. {ECO:0000250}.
FT   METAL       301    301       Zinc. {ECO:0000250}.
FT   METAL       306    306       Zinc. {ECO:0000250}.
FT   BINDING      81     81       ATP; via amide nitrogen. {ECO:0000250}.
FT   BINDING     102    102       ATP. {ECO:0000250}.
FT   BINDING     125    125       ATP. {ECO:0000250}.
FT   BINDING     148    148       ATP. {ECO:0000250}.
FT   BINDING     182    182       ATP. {ECO:0000250}.
SQ   SEQUENCE   402 AA;  43979 MW;  C0B116EB7D896067 CRC64;
     MPYAIDELQE IIGNLRTELV EPIDSGGVNN TRLGRDRVER MSAEVVDSNP YSRLMALQRM
     NIVKDYERIR DKAVAIVGVG GVGSVTADML TRCGIGKLIL FDYDKVELAN MNRLFFTPNQ
     AGLSKVAAAG ATLNFINPDV EIEMFNFNIT TVDNFDRFLN AISQGGRIAG QPVDLVLSCV
     DNFEARMAIN AACNERNLNW FESGVSENAV SGHIQFIRPG DTACFACAPP LVVAENIDEK
     TLKKEGVCAA SLPTTMGITA GFLVQNVLKY LLNFGEVSDY LGYNALSDFF PKMTLKPNPQ
     CDDSNCLVRQ MEFQAKPKPV VVEEKADNEE PLHATNEWGI ELVAENAPEI NPTSTETPVV
     GEGLKLAYEA PEKSSETSEE TVTTAPPDDA SLEDLMAQMK SM
//
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