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Database: UniProt
Entry: B3PM40
LinkDB: B3PM40
Original site: B3PM40 
ID   KITH_MYCA5              Reviewed;         194 AA.
AC   B3PM40;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   16-JAN-2019, entry version 60.
DE   RecName: Full=Thymidine kinase {ECO:0000255|HAMAP-Rule:MF_00124};
DE            EC=2.7.1.21 {ECO:0000255|HAMAP-Rule:MF_00124};
GN   Name=tdk {ECO:0000255|HAMAP-Rule:MF_00124};
GN   OrderedLocusNames=MARTH_orf165;
OS   Mycoplasma arthritidis (strain 158L3-1).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=243272;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=158L3-1;
RX   PubMed=18573899; DOI=10.1128/IAI.00516-08;
RA   Dybvig K., Zuhua C., Lao P., Jordan D.S., French C.T., Tu A.H.,
RA   Loraine A.E.;
RT   "Genome of Mycoplasma arthritidis.";
RL   Infect. Immun. 76:4000-4008(2008).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + thymidine = ADP + dTMP + H(+);
CC         Xref=Rhea:RHEA:19129, ChEBI:CHEBI:15378, ChEBI:CHEBI:17748,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:63528, ChEBI:CHEBI:456216;
CC         EC=2.7.1.21; Evidence={ECO:0000255|HAMAP-Rule:MF_00124};
CC   -!- SUBUNIT: Homotetramer. {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00124}.
CC   -!- SIMILARITY: Belongs to the thymidine kinase family.
CC       {ECO:0000255|HAMAP-Rule:MF_00124}.
DR   EMBL; CP001047; ACF07092.1; -; Genomic_DNA.
DR   RefSeq; WP_012498049.1; NC_011025.1.
DR   ProteinModelPortal; B3PM40; -.
DR   SMR; B3PM40; -.
DR   STRING; 243272.MARTH_orf165; -.
DR   EnsemblBacteria; ACF07092; ACF07092; MARTH_orf165.
DR   KEGG; mat:MARTH_orf165; -.
DR   eggNOG; ENOG4107T8J; Bacteria.
DR   eggNOG; COG1435; LUCA.
DR   HOGENOM; HOG000076390; -.
DR   KO; K00857; -.
DR   OMA; KEQFGWI; -.
DR   OrthoDB; 1279539at2; -.
DR   BioCyc; MART243272:G1GBT-124-MONOMER; -.
DR   Proteomes; UP000008812; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-KW.
DR   HAMAP; MF_00124; Thymidine_kinase; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001267; Thymidine_kinase.
DR   PANTHER; PTHR11441; PTHR11441; 1.
DR   Pfam; PF00265; TK; 1.
DR   PIRSF; PIRSF035805; TK_cell; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Cytoplasm; DNA synthesis; Kinase;
KW   Metal-binding; Nucleotide-binding; Reference proteome; Transferase;
KW   Zinc.
FT   CHAIN         1    194       Thymidine kinase.
FT                                /FTId=PRO_1000095434.
FT   NP_BIND      15     22       ATP. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   NP_BIND      89     92       ATP. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   ACT_SITE     90     90       Proton acceptor. {ECO:0000255|HAMAP-
FT                                Rule:MF_00124}.
FT   METAL       146    146       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   METAL       149    149       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   METAL       178    178       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
FT   METAL       181    181       Zinc. {ECO:0000255|HAMAP-Rule:MF_00124}.
SQ   SEQUENCE   194 AA;  22215 MW;  FA475CE8D51367D0 CRC64;
     MYKNFNEGMI EVITGPMFSG KSEELLKRIR TLEYAKLKPL VIKPEFDTRF SENEIVSRAG
     VKHKTHILKN INDVYFLLQE DKYKAVVIDE AHWFNEELVK VADDLANKGY LVIVAGLDQN
     YLREPFGPIP NLLAIAERVT KLQAICVKCQ HAASTSFRKV AASEINLLGD FQEYEARCRK
     CHNAGQKEKL QKKV
//
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