ID B3R1D5_CUPTR Unreviewed; 413 AA.
AC B3R1D5;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE SubName: Full=Multidrug resistance protein A {ECO:0000313|EMBL:CAQ69782.1};
GN Name=emrA {ECO:0000313|EMBL:CAQ69782.1};
GN OrderedLocusNames=RALTA_A1841 {ECO:0000313|EMBL:CAQ69782.1};
OS Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP
OS 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424)).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=977880 {ECO:0000313|EMBL:CAQ69782.1, ECO:0000313|Proteomes:UP000001692};
RN [1] {ECO:0000313|EMBL:CAQ69782.1, ECO:0000313|Proteomes:UP000001692}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 /
RC R1 {ECO:0000313|Proteomes:UP000001692};
RX PubMed=18490699; DOI=10.1101/gr.076448.108;
RA Amadou C., Pascal G., Mangenot S., Glew M., Bontemps C., Capela D.,
RA Carrere S., Cruveiller S., Dossat C., Lajus A., Marchetti M., Poinsot V.,
RA Rouy Z., Servin B., Saad M., Schenowitz C., Barbe V., Batut J., Medigue C.,
RA Masson-Boivin C.;
RT "Genome sequence of the beta-rhizobium Cupriavidus taiwanensis and
RT comparative genomics of rhizobia.";
RL Genome Res. 18:1472-1483(2008).
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
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DR EMBL; CU633749; CAQ69782.1; -; Genomic_DNA.
DR RefSeq; WP_012353099.1; NC_010528.1.
DR AlphaFoldDB; B3R1D5; -.
DR GeneID; 29761816; -.
DR KEGG; cti:RALTA_A1841; -.
DR eggNOG; COG1566; Bacteria.
DR HOGENOM; CLU_018816_15_0_4; -.
DR BioCyc; CTAI977880:RALTA_RS08870-MONOMER; -.
DR Proteomes; UP000001692; Chromosome 1.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR PANTHER; PTHR30386; MEMBRANE FUSION SUBUNIT OF EMRAB-TOLC MULTIDRUG EFFLUX PUMP; 1.
DR PANTHER; PTHR30386:SF19; MULTIDRUG EXPORT PROTEIN EMRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 2.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022519};
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..352
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 65..295
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 99..126
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 413 AA; 43455 MW; AD3FA60AF88E9295 CRC64;
MSNNQQAAGT NTPQQATATP PNGKRKRMLL SLTAAIVVAG IGYGVYWGLY ARHFESTDDA
YVAGNVVQVT PLVAGTVVSI AADDTQLVTA GQPLIQLDRA DTQVALEQAE AQLAQAVREV
RTLYVNNGSL AANVALREAD VAKARDDLRR RQAIAGSGAV SNEEISHAQA ALKGAESALL
AAREQLASNK VLTDQTTVEH HPNVQRAAAN LRSAYLSFAR SSLPAPVTGY VAKRSVQVGQ
RVAAGAPLMA VVPLDQVWVD ANFKEVQITH MRIGQPVTLE ADVYGSRVEY HGKVAGFSAG
TGSAFSLLPA QNATGNWIKV VQRLPVRIAL DPQQLKDHPL RVGLSMTVKV DVRREEGAAM
AAAAPAKPMQ TDVYDKVAKD ADQLIARIIA ANNGGRGAGL ASASAANAKP ANT
//
