ID B3RCA8_CUPTR Unreviewed; 408 AA.
AC B3RCA8;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Glycosyl transferase, family 2, similar to mouse Ceramide glucosyltransferase {ECO:0000313|EMBL:CAQ72533.1};
DE EC=2.4.1.80 {ECO:0000313|EMBL:CAQ72533.1};
GN OrderedLocusNames=RALTA_B1954 {ECO:0000313|EMBL:CAQ72533.1};
OS Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CCUG 44338 / CIP
OS 107171 / LMG 19424 / R1) (Ralstonia taiwanensis (strain LMG 19424)).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=977880 {ECO:0000313|EMBL:CAQ72533.1, ECO:0000313|Proteomes:UP000001692};
RN [1] {ECO:0000313|EMBL:CAQ72533.1, ECO:0000313|Proteomes:UP000001692}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 17343 / BCRC 17206 / CCUG 44338 / CIP 107171 / LMG 19424 /
RC R1 {ECO:0000313|Proteomes:UP000001692};
RX PubMed=18490699; DOI=10.1101/gr.076448.108;
RA Amadou C., Pascal G., Mangenot S., Glew M., Bontemps C., Capela D.,
RA Carrere S., Cruveiller S., Dossat C., Lajus A., Marchetti M., Poinsot V.,
RA Rouy Z., Servin B., Saad M., Schenowitz C., Barbe V., Batut J., Medigue C.,
RA Masson-Boivin C.;
RT "Genome sequence of the beta-rhizobium Cupriavidus taiwanensis and
RT comparative genomics of rhizobia.";
RL Genome Res. 18:1472-1483(2008).
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00004760}.
CC -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU633750; CAQ72533.1; -; Genomic_DNA.
DR RefSeq; WP_012356746.1; NC_010530.1.
DR AlphaFoldDB; B3RCA8; -.
DR CAZy; GT21; Glycosyltransferase Family 21.
DR GeneID; 29765033; -.
DR KEGG; cti:RALTA_B1954; -.
DR eggNOG; COG1215; Bacteria.
DR HOGENOM; CLU_030898_2_0_4; -.
DR BioCyc; CTAI977880:RALTA_RS24965-MONOMER; -.
DR Proteomes; UP000001692; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008120; F:ceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0102769; F:dihydroceramide glucosyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd02520; Glucosylceramide_synthase; 1.
DR InterPro; IPR025993; Ceramide_glucosylTrfase.
DR InterPro; IPR017835; Hopen-assoc_HpnI.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR NCBIfam; TIGR03472; HpnI; 1.
DR PANTHER; PTHR12726; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR PANTHER; PTHR12726:SF0; CERAMIDE GLUCOSYLTRANSFERASE; 1.
DR Pfam; PF13506; Glyco_transf_21; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000313|EMBL:CAQ72533.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:CAQ72533.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..29
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..299
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 305..327
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 367..408
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 388..408
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 408 AA; 43472 MW; D58FF14A9B6C7E94 CRC64;
MAAGLAAIVP GAALVCVAAG YALAAAWLSR RGPAPRGAMA TTPVSVLKPL CGPEPRLYAN
LATFCRQRHP CFQLVFGVRA ADDPAIAVVE RLRRDFPDCD IALVIDPQVH GSNLKVSNLI
NLFRAARHDA LVIADSDVAV APDYLARVTA PLADAGVGVV TCLYRGHAIG GFWSRLGAQF
IDDWFAPAVR IAHAGGSRRF AFGATIALRR DALAAIGGFE AVRDRLADDF WLGELTRQLG
LRTVLSEVVV TTDIAEDGFT LLWQHELRWM RTIASLNPAG YAFSFVTFTW PMLALGMWLA
PLPLVITAAA VGMIARSVLA GGAAAAWRAP LRDGLLLACW ALALAGKRVR WREQVLSVRD
RQHSGQAPAL SPAILPQAGD GKKQAAGAAT KSSPNHATFT GIQTKRPL
//
