ID B3RIH8_TRIAD Unreviewed; 651 AA.
AC B3RIH8;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN ORFNames=TRIADDRAFT_18816 {ECO:0000313|EMBL:EDV28421.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV28421.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV28421.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV28421.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; DS985241; EDV28421.1; -; Genomic_DNA.
DR RefSeq; XP_002107623.1; XM_002107587.1.
DR AlphaFoldDB; B3RIH8; -.
DR STRING; 10228.B3RIH8; -.
DR EnsemblMetazoa; TriadT18816; TriadP18816; TriadG18816.
DR GeneID; 6748838; -.
DR KEGG; tad:TRIADDRAFT_18816; -.
DR CTD; 6748838; -.
DR eggNOG; KOG1055; Eukaryota.
DR HOGENOM; CLU_005240_3_1_1; -.
DR InParanoid; B3RIH8; -.
DR OMA; EERNSHY; -.
DR OrthoDB; 2918419at2759; -.
DR PhylomeDB; B3RIH8; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0038039; C:G protein-coupled receptor heterodimeric complex; IBA:GO_Central.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IBA:GO_Central.
DR GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IBA:GO_Central.
DR CDD; cd15047; 7tmC_GABA-B-like; 1.
DR CDD; cd06366; PBP1_GABAb_receptor; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR01177; GABAB1RECPTR.
DR PRINTS; PR01176; GABABRECEPTR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 381..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 426..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 463..482
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 503..524
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 560..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 600..620
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 385..651
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDV28421.1"
SQ SEQUENCE 651 AA; 72407 MW; DD57376A3B245235 CRC64;
CDSGVGLKVL FDQLHQKPKK IMVLGAACSV VTQPMAKTSQ YFDLLQLSYA SASPALSIRS
VYRNFFRIYP SETAINPARI GLLKRFGWKK IVLLYQTVEL FSATATSLIQ VAEENEIQVT
ATLGFSSDDD PYQALISIQK SETRIIVGGF YSSQGRKVFC RAYHLGLTGS AYVWIITGWL
EENWWLDPLG EGVTVGNHHC NDSVMTKAVK GYFGMATLAI SSRPQSTISG LTSSEWLQLF
FKYLQRPGAY VGAIDFASFT YDSVWAIALT LNQSINPLSK INKTLEDIDY YDKEALSVFK
DQMQALEFIG ITGPVAFNQN GDRLGITTIK RQIGSKEVIF GLYDNKRETV NWNYSVAITW
QTANNQTPVD SPRIIVVNAS IAIPLFIGIL SIDVIGMLMT IVFLVFNIKS RSIRIIKISS
PNVNNIIAIG AISCYISVFF FGVNTQNINQ HNGLLLASCW CRSWFLVIGY TLGFGALFAK
TWRIHSIFAR KSVKTKLIRD SRLYGIISAA VFVDISIMLA WGIIDPVNIE TKNESVPDFS
HNRDRIMIIS IKQCHSKYPI VWNVLLFGFN GLLLVYGAIL AWQTRQVKMM AVNDSKLIGL
AIYNVAIFAS IGAGIASLVY DKPDAFFGLI SVFIIFPTTV TVCLVFVPKV A
//
