ID B3RIY3_TRIAD Unreviewed; 575 AA.
AC B3RIY3;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN ORFNames=TRIADDRAFT_19120 {ECO:0000313|EMBL:EDV28471.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV28471.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV28471.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV28471.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR EMBL; DS985241; EDV28471.1; -; Genomic_DNA.
DR RefSeq; XP_002107673.1; XM_002107637.1.
DR AlphaFoldDB; B3RIY3; -.
DR STRING; 10228.B3RIY3; -.
DR EnsemblMetazoa; TriadT19120; TriadP19120; TriadG19120.
DR GeneID; 6749686; -.
DR KEGG; tad:TRIADDRAFT_19120; -.
DR CTD; 6749686; -.
DR eggNOG; KOG4171; Eukaryota.
DR HOGENOM; CLU_011614_4_0_1; -.
DR InParanoid; B3RIY3; -.
DR OMA; EERHMHI; -.
DR OrthoDB; 2898719at2759; -.
DR PhylomeDB; B3RIY3; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0008074; C:guanylate cyclase complex, soluble; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IBA:GO_Central.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0019934; P:cGMP-mediated signaling; IBA:GO_Central.
DR GO; GO:0070482; P:response to oxygen levels; IBA:GO_Central.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR PANTHER; PTHR45655:SF13; SOLUBLE GUANYLATE CYCLASE GCY-35-RELATED; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT DOMAIN 431..559
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDV28471.1"
SQ SEQUENCE 575 AA; 65577 MW; 3E1DBDDEEA299DB5 CRC64;
YGIINHVFQV LVEERFGKDT WQQLRNKIDC IPEKFIMKHP YDDNITVDVA EECSKLLGIS
VDQFLETYGQ FFVVWCHRTN YVSMIKVIGS NLFNFLSNLN ALHAHLSMTF NGMKPPEFQC
MPSDDPKKFY LHYYSCRENL FGIVVGATRE AARSLFNRRI SIKIISKTVD NSRYANRHHI
VFEICDLGYA DIKLARTETI AMEPGAAMFV HMNGYSSESF DYQSQTEYVN SKVFCRIFPF
HIIFDQDLII KRVGVGLYRR LQDLNTADKP RLDQFFECLK PPVKLCKRSI KSYRNNDFIL
QCKDKSIKEG NLFQLKGEMV ELEEHGSHYM FICSPVVEKL TDLQNRGLFI SDIPLHDMTR
ELLLLNEQRL AEFQLSKQLE ETTAQLQATS VALEMEKVKA DNLLHSMLPP LVSDRLRNGD
TVEAGEYEQA SIMFSDIVGF TTICSQCRPM DVVQFLNSLY VKFDKLTNVH DVYKVETIGD
AYMVVGGLPE PCANHAEKVA RMALSMVDCA VQVSSPSDNK PLRIRIGIHS GPVVAGVVGS
KMPRYCLFGD TVNTASRMES HGLPSTIHIS EACYK
//
