ID B3RJM9_TRIAD Unreviewed; 605 AA.
AC B3RJM9;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 86.
DE RecName: Full=ATP-dependent DNA helicase {ECO:0000256|RuleBase:RU364117};
DE EC=3.6.4.12 {ECO:0000256|RuleBase:RU364117};
GN ORFNames=TRIADDRAFT_19930 {ECO:0000313|EMBL:EDV28524.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV28524.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV28524.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV28524.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|RuleBase:RU364117};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU364117}.
CC -!- SIMILARITY: Belongs to the helicase family. RecQ subfamily.
CC {ECO:0000256|ARBA:ARBA00005446, ECO:0000256|RuleBase:RU364117}.
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DR EMBL; DS985241; EDV28524.1; -; Genomic_DNA.
DR RefSeq; XP_002107726.1; XM_002107690.1.
DR AlphaFoldDB; B3RJM9; -.
DR STRING; 10228.B3RJM9; -.
DR EnsemblMetazoa; TriadT19930; TriadP19930; TriadG19930.
DR GeneID; 6749741; -.
DR KEGG; tad:TRIADDRAFT_19930; -.
DR CTD; 6749741; -.
DR eggNOG; KOG0353; Eukaryota.
DR HOGENOM; CLU_001103_12_5_1; -.
DR InParanoid; B3RJM9; -.
DR OMA; FKLSTMV; -.
DR OrthoDB; 5474026at2759; -.
DR PhylomeDB; B3RJM9; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0009378; F:four-way junction helicase activity; IBA:GO_Central.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IBA:GO_Central.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IBA:GO_Central.
DR CDD; cd18794; SF2_C_RecQ; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR004589; DNA_helicase_ATP-dep_RecQ.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032284; RecQ_Zn-bd.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00614; recQ_fam; 1.
DR PANTHER; PTHR13710:SF72; ATP-DEPENDENT DNA HELICASE Q1; 1.
DR PANTHER; PTHR13710; DNA HELICASE RECQ FAMILY MEMBER; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF16124; RecQ_Zn_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU364117};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|RuleBase:RU364117};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU364117};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU364117}; Nucleus {ECO:0000256|RuleBase:RU364117};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT DOMAIN 86..263
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 289..440
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT COILED 4..38
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 605 AA; 68570 MW; D52415B6791E1BD5 CRC64;
MEALQEIQQE LSSIDVQVKN LLDRKEQLLQ LQDQLQQEIV QQAKWSGTNC TDWSSDSNFT
WSNQLLQISR DTFGIENFRQ YQLEAMNVTL SEIDCILILP TGAGKSLCYQ IPALLSQGFT
LVISPLVSLM QDQIISLKLK GVEGVEMLSA ETEPSHTKAV YQRMLSDNEG ILKILFVTPE
KIGKSKRFLS NLEKANNCNR LARIVVDEVH CTSQWGNDFR PDYKALGVLK RQFPSVPLLG
LTATASEAIT QDIKTILSLS TCCMIFRGSM TRVNLIYEVR QKPSSHTDTI NDMVSLINDK
FRNQSGIIYC CTRKESETVA SDLVSKGIHA AFYHADMEMS ERSSVHRHWI ENKVNVIVGT
IAFGMGIDKP DVRFVIHHTI SKSIENYYQE SGRAGRDGQL ARCILYYRPL DAFKLSCMVF
MEQTGQKNLY KMLQYCNNIK TCRRKLIADH FVDNIASCNC SICDTCSNSS NVISSDQNEI
CHFILRTIQQ ATDGDVNLTP LKIVKNIQKH FSNLDIFMIE KVIVTMTLRG LLKENLHFTP
YSTICYLIAG MKASTSKQEN FKFVVDTFEN ASMKRQAPKE IARSSSKKLK RQNAVVDDRD
VVTID
//
