ID B3RKW9_TRIAD Unreviewed; 493 AA.
AC B3RKW9;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=REST corepressor {ECO:0008006|Google:ProtNLM};
GN ORFNames=TRIADDRAFT_51793 {ECO:0000313|EMBL:EDV28660.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV28660.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV28660.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV28660.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- SIMILARITY: Belongs to the CoREST family.
CC {ECO:0000256|ARBA:ARBA00038011}.
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DR EMBL; DS985241; EDV28660.1; -; Genomic_DNA.
DR RefSeq; XP_002107862.1; XM_002107826.1.
DR AlphaFoldDB; B3RKW9; -.
DR STRING; 10228.B3RKW9; -.
DR EnsemblMetazoa; TriadT51793; TriadP51793; TriadG51793.
DR GeneID; 6749077; -.
DR KEGG; tad:TRIADDRAFT_51793; -.
DR CTD; 6749077; -.
DR eggNOG; KOG1194; Eukaryota.
DR HOGENOM; CLU_026741_2_0_1; -.
DR InParanoid; B3RKW9; -.
DR OMA; ERETCVW; -.
DR OrthoDB; 3684011at2759; -.
DR PhylomeDB; B3RKW9; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 4.10.1240.50; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR000949; ELM2_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR049048; REST_helical.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR16089:SF28; GEO13032P1-RELATED; 1.
DR PANTHER; PTHR16089; REST COREPRESSOR COREST PROTEIN-RELATED; 1.
DR Pfam; PF01448; ELM2; 1.
DR Pfam; PF00249; Myb_DNA-binding; 2.
DR Pfam; PF20878; REST_helical; 1.
DR SMART; SM01189; ELM2; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51156; ELM2; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
DR PROSITE; PS51293; SANT; 2.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT DOMAIN 44..132
FT /note="ELM2"
FT /evidence="ECO:0000259|PROSITE:PS51156"
FT DOMAIN 133..184
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 356..407
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 360..407
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT DOMAIN 360..403
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 219..233
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..461
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..493
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 56423 MW; C5C38BD6433B00BC CRC64;
MSQYSRTSMG LRSMIRNKES IPQPSPPLTH NSSSENESDS DYEPGMRVGK EYQAVIPDVI
TGGKATQDRA TTKIAEETRI WAPEVSMSDA KIDEFIHYAK TNFGYSLEQA LGMLYWHEYD
IEKSKEDLAN FAPYPNEWSM EDEVLFEQAF DFHGKHFHQI KAMLPDKSVG SLVRYYYSWK
KRKSRLSLLD RQARKPAVPK DATSCENSAE ESSDSDFEPS KGRSNGISSD SRVCSNCGSC
VTHLHSTPKG SICNACYQYW RRTGMMRSNV RIQTRTENEK GKLKKHKRRP PKGMRITREA
LMVIVKGNHE NDSRIFENEI IKLKSQVQRN KQVLSELDEV SVKDIERYRL PESGVRSNAR
WTTEELNIAV EAVRRYGKDY HAIAEVVGNK TVNQCRNFFV NYRRRFNLLQ ILEEFEATHG
KKGRSEWKEN GTDDDLSRSP TKRRKSSQDD TDKDDVSELM HDKSGNGSNN SASYSPDGQR
RSAMSSLIRN GAS
//
