ID B3RPX5_TRIAD Unreviewed; 372 AA.
AC B3RPX5;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial {ECO:0000256|ARBA:ARBA00019998};
GN ORFNames=TRIADDRAFT_53698 {ECO:0000313|EMBL:EDV28258.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV28258.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV28258.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV28258.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Mitochondrion {ECO:0000256|ARBA:ARBA00004173}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ECSIT family.
CC {ECO:0000256|ARBA:ARBA00007674}.
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DR EMBL; DS985242; EDV28258.1; -; Genomic_DNA.
DR RefSeq; XP_002110092.1; XM_002110056.1.
DR AlphaFoldDB; B3RPX5; -.
DR STRING; 10228.B3RPX5; -.
DR EnsemblMetazoa; TriadT53698; TriadP53698; TriadG53698.
DR GeneID; 6750768; -.
DR KEGG; tad:TRIADDRAFT_53698; -.
DR CTD; 6750768; -.
DR eggNOG; KOG3941; Eukaryota.
DR HOGENOM; CLU_046917_1_0_1; -.
DR InParanoid; B3RPX5; -.
DR OMA; EEDFSHW; -.
DR OrthoDB; 4098911at2759; -.
DR PhylomeDB; B3RPX5; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IBA:GO_Central.
DR GO; GO:0007178; P:transmembrane receptor protein serine/threonine kinase signaling pathway; IBA:GO_Central.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR029342; ECIST_C.
DR InterPro; IPR010418; ECSIT.
DR InterPro; IPR046448; ECSIT_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR13113; ECSIT EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAYS; 1.
DR PANTHER; PTHR13113:SF1; EVOLUTIONARILY CONSERVED SIGNALING INTERMEDIATE IN TOLL PATHWAY, MITOCHONDRIAL; 1.
DR Pfam; PF14784; ECSIT_C; 1.
DR Pfam; PF06239; ECSIT_N; 1.
DR SMART; SM01284; ECSIT_Cterm; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946}.
FT DOMAIN 262..354
FT /note="ECSIT C-terminal"
FT /evidence="ECO:0000259|SMART:SM01284"
SQ SEQUENCE 372 AA; 43247 MW; 0BF41847C36CE785 CRC64;
MQVHKIRAGY IRITNTSVTK IITAVLSNWN HTWTFSRCNR LHHGLLRRPT MIASAPIIVK
RFKSNDKIKN LITVGAILEE ALQTKQKDSF HQAIDKFNAR DRQRRGHVDF IYSALSLIDK
FELEQDIETY NKLLDVFPKD RFVNRSWLDV VWPKPHPQID CALDVLTKME EEGILPNEDT
YRILYDVFGR KSFPLQKAQR IEYWFTRFKD INPYKLPSPV PTDPIELGSI ALQRIAGSDG
VITIYEHDKK NGEDKFLLAI QSPNQKQFLT NYDTSKPLLV EGPFRVWLSK YPQYYYVLRA
HASVQIGEEK NEEGLVVGTC MLRGNNMSML NLWIDRLRKE ISQLSNVEII FDINHSQSVP
ITAEDNAIEI ER
//
