ID B3RR64_TRIAD Unreviewed; 665 AA.
AC B3RR64;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN ORFNames=TRIADDRAFT_22642 {ECO:0000313|EMBL:EDV26289.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV26289.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV26289.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV26289.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU280814}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}.
CC -!- SIMILARITY: Belongs to the anoctamin family.
CC {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR EMBL; DS985243; EDV26289.1; -; Genomic_DNA.
DR RefSeq; XP_002110285.1; XM_002110249.1.
DR AlphaFoldDB; B3RR64; -.
DR STRING; 10228.B3RR64; -.
DR EnsemblMetazoa; TriadT22642; TriadP22642; TriadG22642.
DR GeneID; 6752032; -.
DR KEGG; tad:TRIADDRAFT_22642; -.
DR CTD; 6752032; -.
DR eggNOG; KOG2513; Eukaryota.
DR HOGENOM; CLU_006685_2_3_1; -.
DR InParanoid; B3RR64; -.
DR OMA; YEQSKLG; -.
DR OrthoDB; 534027at2759; -.
DR PhylomeDB; B3RR64; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005254; F:chloride channel activity; IBA:GO_Central.
DR GO; GO:1902476; P:chloride transmembrane transport; IBA:GO_Central.
DR InterPro; IPR007632; Anoctamin.
DR InterPro; IPR049452; Anoctamin_TM.
DR PANTHER; PTHR12308; ANOCTAMIN; 1.
DR PANTHER; PTHR12308:SF51; ANOCTAMIN-8; 1.
DR Pfam; PF04547; Anoctamin; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU280814};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU280814}.
FT TRANSMEM 207..231
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 237..257
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 309..331
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 389..410
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 422..444
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 504..527
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 568..587
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 593..613
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT TRANSMEM 638..663
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU280814"
FT DOMAIN 196..630
FT /note="Anoctamin transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04547"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDV26289.1"
SQ SEQUENCE 665 AA; 77150 MW; 02155FFED9D9C4F8 CRC64;
RFTTAGKLIL TANLWYNAIP TQNCDVLVTF PEKADDYDVM WIYNRITKRA PQLQVTVRRH
ANIPVYAFYI TATFENLLQA AEQLSMRKRL KQSHGGGWKE FNLEESKMFL NIENSNDFFT
TRERQTIVFK MVEEIRAEHG DSVGRLVLIE GEPIVPKCLS KGIIKQILPL HSNTDLKKLE
KDWVQAFLRP QPLDEISSYF GVKIAMYFGW LGFYTRSLII PAMIGLLFYL FDTGDALSQV
IFAVFNIIWG TVFLEAWKRK SQEYAYRFGT LDLPNNLVTE PRPLYRGDYQ PSPVTGRLEP
YFPTWKRRLI YCVTIPVILF CISVVFVVML LCFKLQEFFN EHAPAWTVHF PKMLLALSVS
VMDDVYKKIA VKLNDWENYR LEETYENHLI VKLLLFQSVN SFLSLFYIAF YLQDFRRLKQ
QLVALLIVRQ IIGNIKEALV PYVMQKIKFY RMSKKMEKLE QQLLEKHNKG GDETEVEDKT
MLTQAEVECQ MKEYEDTLED YAEMFIQFGY VVLFSSAFPL AAVCALLNNV IEIRSDAFKL
CSSFQRPFSQ SVRGIGEWQF ALESMGNVAV MVNCALLALS GIFQKIYPGI TPVGVVMVTI
LLEHLVFAIK ILVEKAIPDV PEWIETELAK LEYRRRTAYM VIILYTLIRI IYMVSCSSLT
SLIDK
//
