ID B3RSH2_TRIAD Unreviewed; 2119 AA.
AC B3RSH2;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Acetyl-CoA carboxylase {ECO:0008006|Google:ProtNLM};
GN ORFNames=TRIADDRAFT_22916 {ECO:0000313|EMBL:EDV27057.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV27057.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV27057.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV27057.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] =
CC ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate;
CC Xref=Rhea:RHEA:13501, Rhea:RHEA-COMP:10505, Rhea:RHEA-COMP:10506,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:83144, ChEBI:CHEBI:83145,
CC ChEBI:CHEBI:456216; EC=6.3.4.14;
CC Evidence={ECO:0000256|ARBA:ARBA00000861};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-
CC CoA + phosphate; Xref=Rhea:RHEA:11308, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17544, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57288, ChEBI:CHEBI:57384, ChEBI:CHEBI:456216; EC=6.4.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001455};
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- PATHWAY: Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from
CC acetyl-CoA: step 1/1. {ECO:0000256|ARBA:ARBA00004956}.
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DR EMBL; DS985243; EDV27057.1; -; Genomic_DNA.
DR RefSeq; XP_002111053.1; XM_002111017.1.
DR STRING; 10228.B3RSH2; -.
DR EnsemblMetazoa; TriadT22916; TriadP22916; TriadG22916.
DR GeneID; 6752266; -.
DR KEGG; tad:TRIADDRAFT_22916; -.
DR CTD; 6752266; -.
DR eggNOG; KOG0368; Eukaryota.
DR HOGENOM; CLU_000395_5_0_1; -.
DR InParanoid; B3RSH2; -.
DR OMA; PTPKGHC; -.
DR OrthoDB; 911at2759; -.
DR PhylomeDB; B3RSH2; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0003989; F:acetyl-CoA carboxylase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IBA:GO_Central.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR Gene3D; 2.40.460.10; Biotin dependent carboxylase carboxyltransferase; 1.
DR Gene3D; 3.90.1770.10; PreATP-grasp domain; 1.
DR InterPro; IPR049076; ACCA.
DR InterPro; IPR049074; ACCA_BT.
DR InterPro; IPR034733; AcCoA_carboxyl_beta.
DR InterPro; IPR013537; AcCoA_COase_cen.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR011763; COA_CT_C.
DR InterPro; IPR011762; COA_CT_N.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR PANTHER; PTHR45728:SF3; ACETYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR45728; ACETYL-COA CARBOXYLASE, ISOFORM A; 1.
DR Pfam; PF08326; ACC_central; 1.
DR Pfam; PF21385; ACCA_BT; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF01039; Carboxyl_trans; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SUPFAM; SSF52096; ClpP/crotonase; 2.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS50989; COA_CT_CTER; 1.
DR PROSITE; PS50980; COA_CT_NTER; 1.
DR PROSITE; PS00866; CPSASE_1; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT DOMAIN 16..519
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 176..367
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 1465..1801
FT /note="CoA carboxyltransferase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50980"
FT DOMAIN 1802..2116
FT /note="CoA carboxyltransferase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50989"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EDV27057.1"
SQ SEQUENCE 2119 AA; 239270 MW; 5555462CE82C07FB CRC64;
ITTPEEFVRR FGGTRAIEKV LISNNGIAAV KCMTSVRRWS YEMFGNERAI KFCSMVTPDD
LKANAEYIKM ADHYVMVPGG TNNHNYANVD LIVEIAKRTK SQAVWAGWGH ASENPRLPEL
LHKNDIAFIG PPEHAMWALG DKIASSIVAQ TAGVPTMPWS GSGTLKIDWV EEDVAKGKVA
EVTDEVYKKG CVTTVDEGVN SANKIGYPVM IKASEGGGGK GIRKVESEKD FPTLFRQVQS
EVPGSPIFIM KLAKCARHLE VQILADQYGQ AISLYGRDCS VQRRHQKIIE EAPAAIALPE
VFRQMEKAAV TLARMVRYVS AGTVEYLYTE EDGFYFLELN PRLQVEHPCT EMVTDINLPA
AQLQIAMGIP LHRISSIRNF YGENPLEDTP IDFSNIDKRL PPKGHVIAAR ITAENPDENF
KPSGGMIHEL NFRSSNNVWG YFSVIASGSI HEFADSQFGH CFAWGENRED ARRNMVVALQ
KLSIRADFRT TVEYLIKLME TDDFCNNEIS TSWLDALISK KVKAEKPDIM LAVITGALHV
ASNDIQKRYS TYGASLERGQ VLPVNLLTNT VNVELIHDHI KYELQVTRLG LSLYAVVMNS
SYIEVEVHRL SDSGLLISLR GNSYTTYITE EVDKYRVVIG GKTCIFEKES DPTILRSPSA
GKLVQFLVED GGAINPTIPY AEIEARLTHY IQSLLVMKMI MSLISTESGK IHYVKRPGAI
LEPASVLATL ELDDPNLVKK AQLFTGKFTN EQYSRLEGAQ VHQIFKASLE LLLNLMDGYC
IPKSHFIKKL EKNIETLVSC LRDPALPLLE LKEIMHTMSG RIPASIENAI NKELAIYSSN
ITSVLCQFPS QQIANIIDAH ASTLTKRVDR DSFFLNTQTI LQLVRRYRNG TRGHMKSVVI
SMLKKYIEVE TIFNQGNYDK CVAALREKYS DNLSLVVTSI LSHSQVAMKN TAAVMLIDHI
SSNETGLTDE LIAVLSELTK LNNQENAKVA LRARQVLIAA HQPSYQLRRN QVESIFLSAI
DMHGHQFCPD NLQKLIVSET SIFDVLPSFF YHDNNIVKMA ALEVYVRRSY QAYELKSLKH
EKLSGNKWLV EFRFLLPSSH PHRVSMNIKR TKHLSEDLSS YAAKDDSLPP CERIGAMTAI
MIFSDLFRNF AAIIRRFRID PVSPMRSEAR KGLEPLWENQ TSHLYSDEPI HIINVAILKI
DAYKDDALAT MLEKFVHAKK SELIEYGIRR ITILIIEEGG FPKYFTYRAN TIFQEDTIYR
HLEPALAFQL EISRMQAFDI AYITTDNPRM HVYFGKGRKS ANESVTDRRF FIRMIIRHSD
FVTKDASYEY LEKEGERYLL EALDTLEVLV ISPEASTDCN HIFLNFVPTV IMDPTKIEEN
VRRMVLRYGK RLLSLRVLQA EIKMTIRLYM HADQIGLRLV LNSESGYFLS TYLYREYTDN
RTGRVTFQSY GKVQGPMHGL SISVPYMTKD HLQSKRYQAQ QYGTTYVYDF PELFKQAVSY
AWDEYARMNS DVTKPDVLIS CEELVLDDQG QLIVLQRLPG ENQIGMIAWK IKLFAPECPE
GREIILIAND ITLNIGSFGL LEDEVFMKAS ELARRLGIPR IYISVNSGAR IGLAEEVKSL
FKIAWENQNY PERGFKYLYL TPADFAKFSK AKSVKADLIE DEGESRYKIT DIIGMKDGLG
VENLSGSGMI AGETSQAYKD IVTISLVTCR SVGIGAYLIR LGQRVIQAEN TSIILTGAQA
LNKVLGRQVY TSNAQLGGVQ IMYHNGVSHL TVHDDFEGIY SIVKWLSFVA KSIARPLKSR
DAVDREIGYV PSKSSFDARW MLSGKANNDG QWVSGFFDKD SFIEIQRPWA QTVIAGRARL
GGIPVGVITA ETRAVVAEIP ADPANTESEA VILSQAGQVW YPDSSYKTAQ AINDFGREGL
PLMIFANWRG FSGGQRDMFD EILKFGSYIV DALREYKQPI LIYIPPCGEL RGGAWVVLDP
TINPNYMEMY ADKESRGGVL EPEGTVAIKF KKKDIIKTMN RLDANYASLS TACLNKDLKA
EERKKLENEK LERENFLAPM YHEAAVMFAD LHDTAGRMRE KGVIREILDW KTSRRYFYWR
LKRLLAEHEI KQLISAANP
//
