ID B3RSV2_TRIAD Unreviewed; 215 AA.
AC B3RSV2;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 24-JAN-2024, entry version 64.
DE RecName: Full=DNA replication complex GINS protein SLD5 {ECO:0000256|ARBA:ARBA00014804, ECO:0000256|PIRNR:PIRNR007764};
GN ORFNames=TRIADDRAFT_23024 {ECO:0000313|EMBL:EDV26588.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV26588.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV26588.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV26588.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- FUNCTION: The GINS complex plays an essential role in the initiation of
CC DNA replication. {ECO:0000256|PIRNR:PIRNR007764}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR007764}.
CC -!- SIMILARITY: Belongs to the GINS4/SLD5 family.
CC {ECO:0000256|ARBA:ARBA00008187, ECO:0000256|PIRNR:PIRNR007764}.
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DR EMBL; DS985243; EDV26588.1; -; Genomic_DNA.
DR RefSeq; XP_002110584.1; XM_002110548.1.
DR AlphaFoldDB; B3RSV2; -.
DR STRING; 10228.B3RSV2; -.
DR EnsemblMetazoa; TriadT23024; TriadP23024; TriadG23024.
DR GeneID; 6751797; -.
DR KEGG; tad:TRIADDRAFT_23024; -.
DR CTD; 6751797; -.
DR eggNOG; KOG3176; Eukaryota.
DR HOGENOM; CLU_071893_3_0_1; -.
DR InParanoid; B3RSV2; -.
DR OMA; ILETAWI; -.
DR OrthoDB; 1200818at2759; -.
DR PhylomeDB; B3RSV2; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:0000811; C:GINS complex; IBA:GO_Central.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR CDD; cd11711; GINS_A_Sld5; 1.
DR CDD; cd21692; GINS_B_Sld5; 1.
DR Gene3D; 1.20.58.1030; -; 1.
DR Gene3D; 3.40.5.60; -; 1.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR008591; GINS_Sld5.
DR InterPro; IPR031633; SLD5_C.
DR InterPro; IPR038749; Sld5_GINS_A.
DR PANTHER; PTHR21206:SF0; DNA REPLICATION COMPLEX GINS PROTEIN SLD5; 1.
DR PANTHER; PTHR21206; SLD5 PROTEIN; 1.
DR Pfam; PF05916; Sld5; 1.
DR Pfam; PF16922; SLD5_C; 1.
DR PIRSF; PIRSF007764; Sld5; 1.
DR SUPFAM; SSF158573; GINS helical bundle-like; 1.
DR SUPFAM; SSF160059; PriA/YqbF domain; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR007764};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR007764};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022}.
FT DOMAIN 51..124
FT /note="GINS subunit"
FT /evidence="ECO:0000259|Pfam:PF05916"
FT DOMAIN 163..214
FT /note="DNA replication complex GINS protein SLD5 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF16922"
FT COILED 42..69
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 215 AA; 25001 MW; 3842C679ABFA9B75 CRC64;
MDEEQELEGY EESDEYVAMT SAELLDKLKE AWINERMAPE LLNSQDELVE CMIEQLDAME
RNLKTGKRNP LVNSMHGLEM ERVRFLINSY IRCRLGKIEK YVIDVLQQHK ARGQEDLPLL
SRAELEYARE YADGMENHLK STILKFLPTN LQNFDEAKEL PKPNKDKYVF IRVNDQQDQV
LIDDDETTDL NKGARHIVRY SFIASLLSEG SVSLT
//
