ID B3RXD8_TRIAD Unreviewed; 4654 AA.
AC B3RXD8;
DT 02-SEP-2008, integrated into UniProtKB/TrEMBL.
DT 02-SEP-2008, sequence version 1.
DT 27-MAR-2024, entry version 87.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN ORFNames=TRIADDRAFT_24890 {ECO:0000313|EMBL:EDV24404.1};
OS Trichoplax adhaerens (Trichoplax reptans).
OC Eukaryota; Metazoa; Placozoa; Uniplacotomia; Trichoplacea; Trichoplacidae;
OC Trichoplax.
OX NCBI_TaxID=10228 {ECO:0000313|EMBL:EDV24404.1, ECO:0000313|Proteomes:UP000009022};
RN [1] {ECO:0000313|EMBL:EDV24404.1, ECO:0000313|Proteomes:UP000009022}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Grell-BS-1999 {ECO:0000313|EMBL:EDV24404.1,
RC ECO:0000313|Proteomes:UP000009022};
RX PubMed=18719581; DOI=10.1038/nature07191;
RA Srivastava M., Begovic E., Chapman J., Putnam N.H., Hellsten U.,
RA Kawashima T., Kuo A., Mitros T., Salamov A., Carpenter M.L.,
RA Signorovitch A.Y., Moreno M.A., Kamm K., Grimwood J., Schmutz J.,
RA Shapiro H., Grigoriev I.V., Buss L.W., Schierwater B., Dellaporta S.L.,
RA Rokhsar D.S.;
RT "The Trichoplax genome and the nature of placozoans.";
RL Nature 454:955-960(2008).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; DS985245; EDV24404.1; -; Genomic_DNA.
DR RefSeq; XP_002112294.1; XM_002112258.1.
DR STRING; 10228.B3RXD8; -.
DR EnsemblMetazoa; TriadT24890; TriadP24890; TriadG24890.
DR GeneID; 6753507; -.
DR KEGG; tad:TRIADDRAFT_24890; -.
DR CTD; 6753507; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_7_0_1; -.
DR InParanoid; B3RXD8; -.
DR OMA; NERQMTR; -.
DR OrthoDB; 312195at2759; -.
DR PhylomeDB; B3RXD8; -.
DR Proteomes; UP000009022; Unassembled WGS sequence.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0005938; C:cell cortex; IBA:GO_Central.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IBA:GO_Central.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IBA:GO_Central.
DR GO; GO:0031122; P:cytoplasmic microtubule organization; IBA:GO_Central.
DR GO; GO:0007052; P:mitotic spindle organization; IBA:GO_Central.
DR GO; GO:0007097; P:nuclear migration; IBA:GO_Central.
DR GO; GO:0008090; P:retrograde axonal transport; IBA:GO_Central.
DR CDD; cd00009; AAA; 2.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF13; DYNEIN CYTOPLASMIC 1 HEAVY CHAIN 1; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 4.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000009022};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1907..2051
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2222..2373
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2589..2739
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2931..3097
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 3210..3262
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3403..3472
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4654 AA; 530537 MW; 6BED332962C739CF CRC64;
MDQPGDQPDG GVSAEDAESQ AVILADVGKV EDFICRTVSL LLEDGLEKLA PLKKVLSEDQ
SRDQLKKFIS DVQVTSFFVQ RTLLKEEIIE EGDEAAPTEE SNLTVEDNIV YSVSIVVQYS
STKVSSVVFI KRGAVIEDDK TVSSQLRIID FSDGSLFETL HSLMSNAMSP YFKSYVRSVG
SGNREASGDK VLPSVEKKMA ELEMGFLNLQ QNIDIPEVNL IINPSVLSVM KKCSEEDRKP
QVADFGAKVQ DSSFLNALQN GVNRWIKEIQ KVTKLDRDPA SGTALQEISF WLNLERALQR
IQEKRESTEI TLTLDILKHG KRFHATVSFD TDTGLKQAVS QVNDYITLMK DFPLNDLLSV
SELDRMSPAL GSIFAHLRKI RSTKYPVQRA LRLVEAISRD LSNQVLKILS TRRLMHMNID
EFEKVMTTCF EIFVTWDDEY DKLQSLLRDI VKKKREESLK MVWRTNPAHK RLQSRLDHMR
KFRHQHEQLR VVIIRVLKPV GASSASLETV KVHGNTATAV ADGTDGDDSD AIMEVNLAYE
SVKEIDCLDV SKEGNDNWEA AIVRYDERID RVETRIATRL RDQLGTAKNA NEMFRIFSRF
NALFVRPHIR GAIREYQTQL IQRVKDDIEF LHDKFKIQYV HSMAYRMSKV RDLPPVSGSI
IWAKQIDRQL TAYLRRVEDV LGKGWENHVD GQKLKSDGDN FRQKLNPHEL FEDWARKVQG
RNLGVSGKIY SIESQRARVS GRPNYLKLRV SFSPDIITLS KEARNLKALG FRVPLAILNK
AHQANQMYPF AISLIESIKT YEQTCDKVDA GSSISPLVAG LKKDVQSLIA EGASLVWESY
KLDPYVQRLA VASYQFQEKV DDLLMMEERI DADVRSLENC EYNLSTFENI LDKIQKVVDE
LNLHSYTNLS SWVSSLDSKV EKVLGKRLQI SMQLWTDCLK GIDFKDVENK TEIKVHTGGK
PVLKVLVHEI RIKNQVLYLN PPHEEARSNL LKQLHNWLSV VLSQSRIKSS RYQVSFDRYE
DYEDYTYRAI LARLPDGSSV LEDAYNAIEK KLDEVKGYVH IWLQYQSLWD MEGGFVYDRL
GNDLGLWMRL LNDIKKARAT FDNSETKKDF TCIVIDYGQV QSKVNLKYDS WHKDILSKFG
GKLGGDMQSF FTTITKSRTE LESHSVEGAT TAEAVGFITF MQGLKRKLKV WEKQVETYKG
GQKLLERQRF QFPTSWLYYD NVEGEWNAFN DILKRKDAAI QTQVAVLQEK IVSEDRVVEA
RTNDLLGEWE KGKPIAGDIK PDAASASLAI FDGKFVRLRE ERDNLNKARE ALELHEQTSL
VAEDRLSAAY EELMDLKGVW AELSKVWEQI NELKEKTWLS IQPRKLRQSL DGLLNLLKGL
PSRLRQYASY EYVQNVLRSY VKANVLVTEL KSDSLKERHW KMLMKSLRVS WILSELSLGQ
VWDVDLLRHE PAIKDILIVA QGEMALEEFL KQVRDTWQSY ELDLINYQNK CRIIRGWDDL
FNKLKEHINS VAAMKLSPYY KVFEEDALAW EDKLNRINAI FDIWIDVQRR WVYLEGIFSG
SADIKHLLPT ETSRFTSIST EFLGLMKKVA KSPLVLDVLS IQGVQRSLER LADLLGKIQK
ALGEYLERER ASFPRFYFVG DEDLLDIIGN SKNVTKLQKH FKKMFAGVAA LIINEDETAI
KGIVSREGEE VMYLNPVILK DKKINEWLTQ VESEMRMTLA KLLARAVSGM QSFKNVSIPT
DDYLKWIDSY QAQLVTLASQ IAWSENIEAA LEAMASKPDD SEPIENVLKI VKATLGVLAN
CVLQEQPPVR RKKMEHLITE LVHQRDVTRS LMNIKVTSAK AFEWLQQMRF YFDPNQSEVL
KQLTIRMANA SFYYGFEYLG VSDKLVQTPL TDRCYLTMTQ ALDGKYGGSP FGPAGTGKTE
SVKALGNQLG RFVLVFNCDE TFDFQAMGRI FVGLCQVGAW GCFDEFNRLE ERMLSAVSQQ
IQTIQEALKE KALRKGGDKS GPIQVELIGK NVKVSEDMAI FITMNPGYAG RSNLPDNLKK
LFRNLAMTKP DRQLIAQVML YSQGFRTAEV LASKVVPFFR LCQEQLSAQS HYDFGLRALK
SVLVSAGNVK RDRIQSIKED MKNRGEEVDE GQISENLPEQ EILIQSICET MVPKLVADDI
PLLHSLLSDV FPGVAYTQAE MAALKAELKK VCAENHLVYG EGDEIGGSWV EKVLQLFQIS
NLSHGLMMVG PSGSGKSTAW KTLLKALERL EGVEGVAHVI DPKAISKDDL YGFLDPNTRE
WTDGLFTHVL RKIIDNVRGE IGKRQWIIFD GDVDPEWVEN LNSVLDDNKL LTLPNGERLG
IPPNVRIMFE VQDLKYATLA TVSRCGMVWF SEDVLTCDMI FQNFLLKLRN VAVDENEDDI
RIGTGAQDKE EISSCIQVQR DCAAIIEPFF TADGIIMKAI HYAVKLDHIM EFTRLRCLGA
FFSMVNQSVR NILSYNQSHP DFPLPKDQME RYIQAQFVYS LVWTFSGDCK LKARGELSDY
LRSITTIPLP PGNNSLIDYE VSITGEWQSW QSKVPQIEVE THKVAAPDVV VPTVDTVRHE
SLLYTWLAEH KPLVLCGPPG SGKTMTLFSA LRALPDMEVV GLNFSSATTP ELMLKTFDHY
CEYKKTPNGT ILSPIQLGRW LVLFCDEINL PAQDKYGTQR VISFIRQMVE HNGFYRISDH
TWVTLDRIQF VGACNPPTDP GRVPMSHRFL RHVPVVYVDY PGPASLSQIY GTFNRAMLRL
VPNLRTYAQP LTEAMVEFYT MSQERFTPDM QPHYIYSPRE MTRWVRGILE ALRPVESLSV
EGLVRVWAHE ALRLFQDRLV FDEERKWTDD NIDNVSLKHF PGIEKEAALG RPILFSNWLS
KDYTPVDREE LREYVKARLK VFYEEELDVP LVLFNEVLDH VLRIDRIFKQ TQGHLLFIGV
SGAGKTTLSR FVAWMNGMSM YQIKVHNKYT GDDFDEDLRV VLRRAGTKDE KIVFILDESN
VLDSGFLERM NTLLANGEVP GLFEGDEHTT LMTQCKEGSQ RDGHMLDSNE ELYKWFTNQV
CRNLHVVFTM NPSEDGLKDR AATSPALFNR CVLNWFGDWS WHAYYQVGRE FTDKLDLERS
DYIAPEYFPV AYEGVSIPPT HREAIVNGFV YVHQTLHKTN DRERKRGNRT MAITPRHYLD
FINQYVKLHH EKRADLEEQQ LHLNVGLQKI RDTVDQVEEL QKSLAIKSRE LEAKNDAANQ
KLKQMVKDQQ EAEQKKVEAQ DVQVRVETQT KEIAERREVV EEDLAKVEPA VKDAAQAVKS
IKKQHLVEVR SMGNPPVIVK MALESICLLL GENTTDWKAI RGVLMKDNFI GTIVNFTTEN
MSDSIRRKMD KYLNDPNYNF EKVNRASAAC GPLVKWAIAQ CGYAEMLQKV EPLRNELRQL
EKQANVNKAK KEELEKTVTQ LEKSIAMYKE EYAKLISEAQ AIKADKESVE AKVTRSQALL
RSLSSERERW ESTSNTFKTQ MSTIVGDVLL SAAFMAYAGY FDQQLREYLW STLSNHLHQA
GVLYRSDLAL TEYLCTPDDR LRWQANSLPA DDLCNENAIM LQRFNRYPLI IDPSGQATAF
LLQEFKDKKI TRTSFLDDAF RKNLESALRF GNPLLVQDVE SYDPILNPVL NKEVRRNAGR
VLITIGDQDI DLSPAFTIFL STRDPTVEFP PDVCSRVTFV NFTVTHSSLQ SQCLNKVLKA
ERPDIDAKRS DLLKLQGEYK LRLRQLEKSL LQALNDSKGR ILDDDSVITT LETLKKEAAE
ISNKVEETDT IMAEVETVSK QYRPLALSCS SIYFTIDRLH QMHFLYQYSL HFFLAIFENV
LYDNSHLKGI TGHAERLKVV TDDLFQIVYN RVARGMLHED RIAFAMLLAQ IFVKGISGSV
NLDEEFNHLL RGNEFGQVDQ QGNELPGLNR EQSSAIHRIS KLHVFKDVGN EIVSQGEDFT
KWLQSNSPEL NVPILWKAPT DKHKSPFVTA LYQLLLIASL RPDRILRMST LFVQKAINEK
FLQEADLELN LGEIVDKEIK PSTPVLLCSV PGYDASSRVD DLAAEQGKQC TSIAIGSAEG
FTLADKAISS AAKSGRWVML KNVHLAPQWL VQLEKKLHSL STHTNFRLFM TLEINPKVPV
NLLRVSRIFV FEPPPGVKAN LLRTFSTVPS ARMCKSPNER ARIYFLLAWF HAIVQERLRY
SPLGWSKKYE FNESDLRCGC DTLDTWLDSV SQGRSNISPN KIPWDALCTL LSQSIYGGKI
DNEFDQRLMT SFLSRIFGID SFDSEFQLVK RVAGEDSEQI LVPEGIRREQ FLQWIENLPD
AQTPSWLGLP NNAEKVLLTA RGNAMLQKLL KMQGMGETEE LEPASGEEKQ AGDVRPAWMR
TLHTTATTWL AAVPESLPGL KRTVDNIKDP LFRFFDRECK IGISLLRTVL RDLRDVIDIC
AGAKKSTNHH RSIMSELTRG ILPRGWSRYV VPRNTTVIQW IADFSERIKQ LQKIVSATNA
DGAKALKVLS VDLGRLFVPE AFVTATRQFV AQANNWSLEE LFLDIYVTNK GEKMTADDCS
FGVTGLKLMG SNCSNNILQL SSSIATDLPL SFLKWIRRTA DTRGTNGVTL PVYLNRTRSE
LLFTLDFAMS GEGSGKNHSF YERGVALYCS DLVG
//
